scholarly journals Nuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains

Biochemistry ◽  
2016 ◽  
Vol 55 (35) ◽  
pp. 4949-4959 ◽  
Author(s):  
Jung Ho Lee ◽  
Jinfa Ying ◽  
Ad Bax
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Side Chains ◽  
Membrane Interaction ◽  
Nuclear Magnetic

Semiempirical calculation of 13C nuclear magnetic resonance chemical shifts of acyclic hydrocarbons. Application to the stereochemical analysis of steroidal side chains

1988 ◽  
Vol 66 (1) ◽  
pp. 71-75 ◽  
Author(s):  
Manuel Gonzalez-Sierra ◽  
Daniel A. Bustos ◽  
Edmundo A. Ruveda ◽  
Alejandro C. Olivieri ◽  
Mariano Grasselli
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Side Chains ◽  
Stereochemical Analysis ◽  
Microcomputer Program ◽  
Semiempirical Approach ◽  
13C Nuclear Magnetic Resonance ◽  
Acyclic Hydrocarbons ◽  
Nuclear Magnetic

A semiempirical approach for predicting 13C nuclear magnetic resonance chemical shifts of acyclic hydrocarbons has been adapted to a microcomputer program. A series of methyl and dimethyl substituted cholesterols has been studied using this program, and the predicted shifts are in agreement with literature reports. Preferred conformations of the steroidal side chains have been also predicted and agree with previous studies. A simple rule for analyzing the trends in the chemical shift of the carbon C-20, which is sensitive to changes in the configuration at C-22, is also given, not only for hydrocarbon side chains but also for hydroxy substituted compounds.

FRIEDEL–CRAFTS REARRANGEMENTS: II. REARRANGEMENTS DURING CYCLIALKYLATION OF ε-ARYL-SUBSTITUTED COMPOUNDS

1964 ◽  
Vol 42 (3) ◽  
pp. 579-590 ◽  
Author(s):  
L. R. C. Barclay ◽  
B. A. Ginn ◽  
C. E. Milligan
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Side Chains ◽  
Alternative Mechanism ◽  
Nuclear Magnetic

Friedel–Crafts cyclialkylation of aromatics such as 1,1,4,4-tetramethyltetralin with 2,6-dichloro-2,6-dimethylheptane does not yield a benzsuberane as previously reported. Several 5-phenyl-substituted chlorides, alcohols, and olefins were synthesized for cyclialkylation studies. These included 2-chloro-2,6-dimethyl-6-phenylheptane (Xa), 3-chloro-3,7-dimethyl-7-phenyloctane (Xb), 2,6-dimethyl-6-phenyl-2-heptanol, 2,6-dimethyl-6-phenyl-2-hepten-4-one (XX), 2-chloro-6-methyl-6-phenylheptane, and 1-chloro-5-phenylpentane (XXIV). Cyclialkylation of Xa (and the corresponding alcohol), Xb, 2-chloro-6-methyl-6-phenyl-heptane, and XXIV produced alkyltetralins instead of benzsuberanes. Evidence is presented and discussed which indicates that the alkyltetralins form by rearrangements in the side chains of the aryl-substituted systems. The alternative mechanism involving rearrangement of a benzsuberane intermediate via a phenonium ion mechanism was unequivocally ruled out in at least one case—the cyclization of Xb. Nuclear magnetic resonance evidence is presented for the structural assignments.

Sign in / Sign up

Export Citation Format

Share Document