Cg10062 Catalysis Forges a Link between Acetylenecarboxylic Acid and Bacterial Metabolism

Biochemistry ◽  
2021 ◽  
Author(s):  
Amaya Mathes Hewage ◽  
Hadi Nayebi Gavgani ◽  
Daniel Chi ◽  
Bryan Qiu ◽  
James H. Geiger ◽  
...  
Keyword(s):  
Bacterial Metabolism

Pilot Study of Probiotic Supplementation on Uremic Toxicity and Inflammatory Cytokines in Chronic Kidney Patients

2020 ◽  
Vol 16 (4) ◽  
pp. 470-480
Author(s):  
Cristina T. Roth-Stefanski ◽  
Carla Dolenga ◽  
Lia S. Nakao ◽  
Roberto Pecoits-Filho ◽  
Thyago P. de Moraes ◽  
...  
Keyword(s):  
Pilot Study ◽  
Inflammatory Cytokines ◽  
Lactobacillus Acidophilus ◽  
Serum Levels ◽  
Uremic Toxins ◽  
Indoxyl Sulfate ◽  
Bacterial Metabolism ◽  
Probiotic Supplementation ◽  
Primary Endpoints ◽  
Inflammatory Profile

Background: Bacterial metabolism contributes to the generation of uremic toxins in patients with chronic kidney disease (CKD). It has been investigated the use of probiotics in the reduction of uremic toxins intestinal production. Objective: The aim of this pilot study was to evaluate the effect of probiotic supplementation on reducing the production of uremic toxins and the inflammatory profile of CKD patients. Methods: We performed a randomized, blind, placebo-controlled, crossover study on patients with CKD stages 3 and 4. The intervention was a probiotic formulation composed of Lactobacillus acidophilus strains given orally three times a day for 3 months. Changes in uremic toxins (p-Cresylsulfate and Indoxyl Sulfate) and serum inflammatory cytokines were the primary endpoints. Results: Of the 44 patients randomized, 25 completed the study (mean age 51 ± 9.34, 64% female, mean eGFR 36 ± 14.26 mL/min/1.73m², mean BMI 28.5 ± 5.75 kg/m²). At 3 months, there were no significant changes in any of the studied biomarkers including p-cresylsulfate (p = 0.57), Indoxyl sulfate (p = 0.08) and interleukin-6 (p = 0.55). Conclusion: Lactobacillus acidophilus strains given as probiotic were not able to reduce serum levels of uremic toxins and biomarkers of inflammation in CKD patients in stage 3 and 4.

scholarly journals STUDIES IN BACTERIAL METABOLISM. II

1912 ◽  
Vol 12 (1) ◽  
pp. 19-21
Author(s):  
Arthur I. Kendall ◽  
Chester J. Farmer
Keyword(s):  
Bacterial Metabolism

scholarly journals STUDIES IN BACTERIAL METABOLISM. III

1912 ◽  
Vol 12 (2) ◽  
pp. 215-218
Author(s):  
Arthur I. Kendall ◽  
Chester J. Farmer
Keyword(s):  
Bacterial Metabolism

Bacterial Metabolism of Steroids

2019 ◽  
pp. 315-336
Author(s):  
Beatriz Galán ◽  
Julia García-Fernández ◽  
Carmen Felpeto-Santero ◽  
Lorena Fernández-Cabezón ◽  
José L. García
Keyword(s):  
Bacterial Metabolism

Bacterial Metabolism

1947 ◽  
Vol 16 (1) ◽  
pp. 605-630 ◽  
Author(s):  
D D Woods
Keyword(s):  
Bacterial Metabolism

Bacterial Metabolism

1947 ◽  
Vol 1 (1) ◽  
pp. 115-140 ◽  
Author(s):  
D D Woods
Keyword(s):  
Bacterial Metabolism

Bacterial metabolism of environmental arsenic—mechanisms and biotechnological applications

2013 ◽  
Vol 97 (9) ◽  
pp. 3827-3841 ◽  
Author(s):  
Martin C. Kruger ◽  
Philippe N. Bertin ◽  
Hermann J. Heipieper ◽  
Florence Arsène-Ploetze
Keyword(s):  
Bacterial Metabolism ◽  
Biotechnological Applications
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