Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis

Biochemistry ◽  
2020 ◽  
Vol 59 (51) ◽  
pp. 4787-4792
Author(s):  
Takuma Matsushita ◽  
Shinji Kishimoto ◽  
Kodai Hara ◽  
Hiroshi Hashimoto ◽  
Kenji Watanabe
Keyword(s):  
Natural Product ◽  
Natural Product Biosynthesis ◽  
Functional Analyses

Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis

2021 ◽  
Author(s):  
Sofie Dekimpe ◽  
Joleen Masschelein
Keyword(s):  
Natural Product ◽  
Bond Formation ◽  
Peptide Bond ◽  
Chemical Diversity ◽  
Peptide Bond Formation ◽  
Natural Product Biosynthesis

Condensation domains perform highly diverse functions during natural product biosynthesis and are capable of generating remarkable chemical diversity.

Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota

2021 ◽  
Author(s):  
Markus Gressler ◽  
Nikolai A. Löhr ◽  
Tim Schäfer ◽  
Stefanie Lawrinowitz ◽  
Paula Sophie Seibold ◽  
...  
Keyword(s):  
Natural Product ◽  
Biosynthetic Genes ◽  
Natural Product Biosynthesis

This article comprehensively reviews basidiomycete enzymes and their genes involved in natural product biosynthesis and primarily focuses on typical pathways and enzymes, along with the methods applied to investigate mushroom metabolism.

scholarly journals Heronapyrrole D: A case of co-inspiration of natural product biosynthesis, total synthesis and biodiscovery

2014 ◽  
Vol 10 ◽  
pp. 1228-1232 ◽  
Author(s):  
Jens Schmidt ◽  
Zeinab Khalil ◽  
Robert J Capon ◽  
Christian B W Stark
Keyword(s):  
Antibacterial Activity ◽  
Natural Products ◽  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Natural Product ◽  
Joint Effort ◽  
Natural Product Biosynthesis ◽  
New Members ◽  
Degree Of Oxidation ◽  
Rare Class

The heronapyrroles A–C have first been isolated from a marine-derived Streptomyces sp. (CMB-0423) in 2010. Structurally, these natural products feature an unusual nitropyrrole system to which a partially oxidized farnesyl chain is attached. The varying degree of oxidation of the sesquiterpenyl subunit in heronapyrroles A–C provoked the hypothesis that there might exist other hitherto unidentified metabolites. On biosynthetic grounds a mono-tetrahydrofuran-diol named heronapyrrole D appeared a possible candidate. We here describe a short asymmetric synthesis of heronapyrrole D, its detection in cultivations of CMB-0423 and finally the evaluation of its antibacterial activity. We thus demonstrate that biosynthetic considerations and the joint effort of synthetic and natural product chemists can result in the identification of new members of a rare class of natural products.

The Study of Plant Natural Product Biosynthesis in the Pregenomics and Genomics Eras

2006 ◽  
pp. 203-220
Author(s):  
Peter Kaufman ◽  
Feng Chen ◽  
Leland Cseke ◽  
Joshua Yuan ◽  
Ara Kirakosyan ◽  
...  
Keyword(s):  
Natural Product ◽  
Natural Product Biosynthesis
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