scholarly journals A Model for the Solution Structure of Human Fe(II)-Bound Acireductone Dioxygenase and Interactions with the Regulatory Domain of Matrix Metalloproteinase I (MMP-I)

Biochemistry ◽  
2020 ◽  
Vol 59 (44) ◽  
pp. 4238-4249
Author(s):  
Xinyue Liu ◽  
Abigail Garber ◽  
Julia Ryan ◽  
Aditi Deshpande ◽  
Dagmar Ringe ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Solution Structure ◽  
Regulatory Domain ◽  
Acireductone Dioxygenase

scholarly journals The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase

2014 ◽  
Vol 426 (7) ◽  
pp. 1483-1497 ◽  
Author(s):  
Shengnan Zhang ◽  
Tao Huang ◽  
Udayar Ilangovan ◽  
Andrew P. Hinck ◽  
Paul F. Fitzpatrick
Keyword(s):  
Tyrosine Hydroxylase ◽  
Solution Structure ◽  
Regulatory Domain

Solution Structure of the p53 Regulatory Domain of the p19ArfTumor Suppressor Protein†

Biochemistry ◽  
2001 ◽  
Vol 40 (8) ◽  
pp. 2379-2386 ◽  
Author(s):  
Enrico L. DiGiammarino ◽  
Igor Filippov ◽  
Jason D. Weber ◽  
Brian Bothner ◽  
Richard W. Kriwacki
Keyword(s):  
Solution Structure ◽  
Regulatory Domain

scholarly journals Solution Structure and Main Chain Dynamics of the Regulatory Domain (Residues 1–91) of Human Cardiac Troponin C

1998 ◽  
Vol 273 (25) ◽  
pp. 15633-15638 ◽  
Author(s):  
Kimmo Pääkkönen ◽  
Arto Annila ◽  
Tia Sorsa ◽  
Piero Pollesello ◽  
Carola Tilgmann ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Solution Structure ◽  
Main Chain ◽  
Troponin C ◽  
Regulatory Domain ◽  
Chain Dynamics ◽  
Cardiac Troponin C ◽  
Human Cardiac Troponin C

scholarly journals An order-to-disorder structural switch activates the FoxM1 transcription factor

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Aimee H Marceau ◽  
Caileen M Brison ◽  
Santrupti Nerli ◽  
Heather E Arsenault ◽  
Andrew C McShan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Transcription Factors ◽  
Solution Structure ◽  
Structural Plasticity ◽  
Regulatory Domain ◽  
Ordered Structures ◽  
Intrinsically Disordered ◽  
Transactivation Domains ◽  
Transcriptional Machinery

Intrinsically disordered transcription factor transactivation domains (TADs) function through structural plasticity, adopting ordered conformations when bound to transcriptional co-regulators. Many transcription factors contain a negative regulatory domain (NRD) that suppresses recruitment of transcriptional machinery through autoregulation of the TAD. We report the solution structure of an autoinhibited NRD-TAD complex within FoxM1, a critical activator of mitotic gene expression. We observe that while both the FoxM1 NRD and TAD are primarily intrinsically disordered domains, they associate and adopt a structured conformation. We identify how Plk1 and Cdk kinases cooperate to phosphorylate FoxM1, which releases the TAD into a disordered conformation that then associates with the TAZ2 or KIX domains of the transcriptional co-activator CBP. Our results support a mechanism of FoxM1 regulation in which the TAD undergoes switching between disordered and different ordered structures.

Solution structure of wild-type human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor

2008 ◽  
Vol 41 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Michelle A. Markus ◽  
Brian Dwyer ◽  
Scott Wolfrom ◽  
Jianchang Li ◽  
Wei Li ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Solution Structure ◽  
Tight Binding ◽  
Wild Type ◽  
Matrix Metalloproteinase 12
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