Broad Spectrum Analysis of 109 Priority Compounds Listed in the 76/464/CEE Council Directive Using Solid-Phase Extraction and GC/EI/MS

2000 ◽  
Vol 72 (7) ◽  
pp. 1430-1440 ◽  
Author(s):  
Sílvia Lacorte ◽  
Ingrid Guiffard ◽  
Daniel Fraisse ◽  
Damià Barceló
Keyword(s):  
Solid Phase Extraction ◽  
Broad Spectrum ◽  
Spectrum Analysis ◽  
Solid Phase ◽  
Phase Extraction ◽  
Council Directive

scholarly journals Clinical evaluation of Toxi · Prep™: a semiautomated solid-phase extraction system for screening of drugs in urine

1997 ◽  
Vol 43 (11) ◽  
pp. 2099-2105 ◽  
Author(s):  
David M Steinberg ◽  
Lori J Sokoll ◽  
Kathy C Bowles ◽  
James H Nichols ◽  
Roger Roberts ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Broad Spectrum ◽  
Solid Phase ◽  
Phase Extraction ◽  
Basic Drugs ◽  
Time And Motion ◽  
Sample Extraction ◽  
Screening And Identification ◽  
Motion Studies ◽  
Drugs And Metabolites

Abstract A prototype Toxi · Prep (TP) system that utilizes solid-phase extraction (SPE) has been developed as a method for broad-spectrum drug screening and identification of tetrahydrocannabinol (THC) metabolites in urine. TP can simultaneously extract up to seven specimens while automating the process of sample extraction, washing, and elution onto a chromatogram. TP was compared with the Toxi · Lab A (TL-A) system for extraction of basic drugs only. In a blind study, 33 distinct drugs and metabolites were detected in 55 urines over 13 runs. Of the drug occurrences, 68.8% (141 of 205) were detected on both TP and TL-A. Of the 13 runs, quinidine and quinine, nortriptyline metabolites, and diphenhydramine were noted more frequently on TP than TL-A, whereas nicotine and metabolites, morphine, and methadone metabolites were more frequently noted on TL-A. Twenty specimens were analyzed for THC metabolites. Of the cases positive for THC metabolites, 100% (16 of 16) were positive by both methods. Time and motion studies for all runs proved an overall labor reduction for extraction and spotting by ∼40%.

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