Role of the Carbohydrate Moieties in Chiral Recognition on Teicoplanin-Based LC Stationary Phases

2000 ◽  
Vol 72 (8) ◽  
pp. 1767-1780 ◽  
Author(s):  
Alain Berthod ◽  
Xianghong Chen ◽  
John P. Kullman ◽  
Daniel W. Armstrong ◽  
Francesco Gasparrini ◽  
...  
Keyword(s):  
Chiral Recognition ◽  
Stationary Phases

scholarly journals T7 phage factor required for managing RpoS inEscherichia coli

2018 ◽  
Vol 115 (23) ◽  
pp. E5353-E5362 ◽  
Author(s):  
Aline Tabib-Salazar ◽  
Bing Liu ◽  
Declan Barker ◽  
Lynn Burchell ◽  
Udi Qimron ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Stationary Phases ◽  
Inescherichia Coli ◽  
E Coli ◽  
Bacterial Transcription ◽  
Bacterial Rna ◽  
Predominant Form ◽  
Phage Development ◽  
T7 Phage

T7 development inEscherichia colirequires the inhibition of the housekeeping form of the bacterial RNA polymerase (RNAP), Eσ70, by two T7 proteins: Gp2 and Gp5.7. Although the biological role of Gp2 is well understood, that of Gp5.7 remains to be fully deciphered. Here, we present results from functional and structural analyses to reveal that Gp5.7 primarily serves to inhibit EσS, the predominant form of the RNAP in the stationary phase of growth, which accumulates in exponentially growingE. colias a consequence of the buildup of guanosine pentaphosphate [(p)ppGpp] during T7 development. We further demonstrate a requirement of Gp5.7 for T7 development inE. colicells in the stationary phase of growth. Our finding represents a paradigm for how some lytic phages have evolved distinct mechanisms to inhibit the bacterial transcription machinery to facilitate phage development in bacteria in the exponential and stationary phases of growth.

The “Bridge” Game: Role of the Fourth Player in Chiral Recognition

2011 ◽  
Vol 17 (11) ◽  
pp. 3078-3081 ◽  
Author(s):  
Caterina Fraschetti ◽  
Marco Pierini ◽  
Claudio Villani ◽  
Francesco Gasparrini ◽  
Stefano Levi Mortera ◽  
...  
Keyword(s):  
Chiral Recognition
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