A Nonempirical Method Using LC/MS for Determination of the Absolute Configuration of Constituent Amino Acids in a Peptide:  Combination of Marfey's Method with Mass Spectrometry and Its Practical Application

1997 ◽  
Vol 69 (24) ◽  
pp. 5146-5151 ◽  
Author(s):  
Kiyonaga Fujii ◽  
Yoshitomo Ikai ◽  
Hisao Oka ◽  
Makoto Suzuki ◽  
Ken-ichi Harada
Keyword(s):  
Mass Spectrometry ◽  
Amino Acids ◽  
Absolute Configuration ◽  
Practical Application ◽  
Nonempirical Method ◽  
The Absolute

scholarly journals Rapid Organocatalytic Chirality Analysis of Amines, Amino Acids, Alcohols, Amino Alcohols and Diols with Achiral Iso(thio)cyanate Probes

2021 ◽  
Author(s):  
Eryn Nelson ◽  
Jeffrey S. S. K. Formen ◽  
Christian Wolf
Keyword(s):  
Amino Acids ◽  
Absolute Configuration ◽  
Rapid Determination ◽  
Amino Alcohols ◽  
Enantioselective Synthesis ◽  
Widespread Occurrence ◽  
Chiral Compounds ◽  
New Methods ◽  
The Absolute

The widespread occurrence and significance of chiral compounds does not only require new methods for their enantioselective synthesis but also efficient tools that allow rapid determination of the absolute configuration,...

Determination of the Absolute Configuration of Peptide Natural Products by Using Stable Isotope Labeling and Mass Spectrometry

2012 ◽  
Vol 18 (8) ◽  
pp. 2342-2348 ◽  
Author(s):  
Helge B. Bode ◽  
Daniela Reimer ◽  
Sebastian W. Fuchs ◽  
Ferdinand Kirchner ◽  
Christina Dauth ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Natural Products ◽  
Stable Isotope ◽  
Absolute Configuration ◽  
Isotope Labeling ◽  
Stable Isotope Labeling ◽  
The Absolute

Determination of the Absolute Configuration of Amines and α-Amino Acids by1H NMR of (R)-O-Aryllactic Acid Amides†

1996 ◽  
Vol 61 (21) ◽  
pp. 7285-7290 ◽  
Author(s):  
Rafael Chinchilla ◽  
Larry R. Falvello ◽  
Carmen Nájera
Keyword(s):  
Amino Acids ◽  
Absolute Configuration ◽  
The Absolute

Stereoselective Reaction Mass Spectrometry with Cyclic α-Amino Acids

1991 ◽  
Vol 46 (3) ◽  
pp. 320-325 ◽  
Author(s):  
Jürgen Martens ◽  
Stefan Lübben ◽  
Walter Schwarting
Keyword(s):  
Mass Spectrometry ◽  
Amino Acids ◽  
Amino Acid ◽  
Absolute Configuration ◽  
Mass Spectra ◽  
Reaction Mass ◽  
Chiral Selector ◽  
Enantiomerically Pure ◽  
Stereoselective Reaction ◽  
The Absolute

Stereoselective reaction mass spectrometry in the chemical ionization (isobutane) mode has been used to detect the absolute configuration of enantiomerically pure cyclic α-amino acids. Thus, an enantiomerically pure cyclic α-amino acid was allowed to react on a micromole level with both enantiomers of a chiral selector and the mass spectra were detected. The relative abundances of characteristic ions formed by the diastereoselective reaction between the α-amino acid and the chiral selector of the same configuration were much higher than those ions formed by the α-amino acid and the chiral selector of a different configuration. The absolute configuration of the α-amino acid may be predicted by careful examination of the two stereoselective reaction mass spectra of the α-amino acid measured with both, the chiral (R)-and (S)-selector respectively. Various (R)- and (S)-carboxylic acids and (R)- and (S)-α-phenylethyl amine have been used as chiral selectors.

Simultaneous detection and determination of the absolute configuration of thiazole-containing amino acids in a peptide

Tetrahedron ◽  
2002 ◽  
Vol 58 (34) ◽  
pp. 6873-6879 ◽  
Author(s):  
Kiyonaga Fujii ◽  
Yukie Yahashi ◽  
Tomoyo Nakano ◽  
Susumu Imanishi ◽  
Susana F Baldia ◽  
...  
Keyword(s):  
Amino Acids ◽  
Absolute Configuration ◽  
Simultaneous Detection ◽  
The Absolute
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