Nanoparticle-Based Sandwich Electrochemical Immunoassay for Carbohydrate Antigen 125 with Signal Enhancement Using Enzyme-Coated Nanometer-Sized Enzyme-Doped Silica Beads

2010 ◽  
Vol 82 (4) ◽  
pp. 1527-1534 ◽  
Author(s):  
Dianping Tang ◽  
Biling Su ◽  
Juan Tang ◽  
Jingjing Ren ◽  
Guonan Chen
Keyword(s):  
Carbohydrate Antigen ◽  
Signal Enhancement ◽  
Electrochemical Immunoassay ◽  
Carbohydrate Antigen 125 ◽  
Silica Beads

Sensitive electrochemical immunoassay with signal enhancement based on nanogold-encapsulated poly(amidoamine) dendrimer-stimulated hydrogen evolution reaction

The Analyst ◽  
2015 ◽  
Vol 140 (23) ◽  
pp. 7948-7954 ◽  
Author(s):  
Ai-Li Sun
Keyword(s):  
Hydrogen Evolution ◽  
Hydrogen Evolution Reaction ◽  
Carbohydrate Antigen ◽  
Electrochemical Immunosensor ◽  
Signal Enhancement ◽  
Sensitive Detection ◽  
Electrochemical Immunoassay ◽  
Related Protein

A new electrochemical immunosensor with signal enhancement was designed for sensitive detection of disease-related protein (human carbohydrate antigen 19-9, CA 19-9 used in this case).

Glucometer-based signal readout for a portable low-cost electrochemical immunoassay using branched platinum nanowires

2016 ◽  
Vol 8 (20) ◽  
pp. 4069-4074 ◽  
Author(s):  
Jiashi Lin ◽  
Dianping Tang
Keyword(s):  
Low Cost ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Quantitative Detection ◽  
Electrochemical Immunoassay ◽  
Platinum Nanowires ◽  
Carbohydrate Antigen 125 ◽  
Electrochemical Immunosensing ◽  
Hydrolysis Of ◽  
Signal Readout

A simple and low-cost electrochemical immunosensing platform with a personal glucometer (PGM)-based signal readout device was developed for the quantitative detection of human carbohydrate antigen 125 (CA 125) using invertase for the hydrolysis of sucrose.

scholarly journals Benign Ovarian Cysts with Raised CA-125 Levels: Do We Need to Evaluate the Fallopian Tubes?

2020 ◽  
Vol 12 (04) ◽  
pp. 276-280
Author(s):  
Devesh Sharma ◽  
Anjali Vinocha
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Cyst ◽  
Transvaginal Ultrasound ◽  
Premenopausal Women ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Ovarian Cysts ◽  
Fallopian Tubes ◽  
Case Record ◽  
Carbohydrate Antigen 125

Abstract Objectives It is not clearly known whether some benign (simple) ovarian cysts can convert into cancerous cysts. Size of cyst and wall abnormalities do predict the potentiality of malignancy. Not many studies have been done to explore the malignant potential of large-sized (> 5 cm) unilocular ovarian cysts without wall abnormalities. This study evaluated the correlation between ultrasonographic size of benign ovarian cysts and carbohydrate antigen 125 (CA-125) levels. Methodology Sixty (60) premenopausal women were recruited for the study preoperatively, based on transvaginal ultrasound (TVUS) findings present in the case record sheet received along with the CA-125 sample in the biochemistry laboratories. Those cases with elevated CA-125 levels were selected, where patients had unilocular ovarian cysts without wall abnormalities. CA-125 was done using ECLIA methodology (Cobas e411, Germany). Statistical correlation was calculated between the ovarian cyst size and CA-125 levels using Spearman’s Rho coefficient. Results Mean age group of subjects were 29.7 ± 7.3 years and mean value of CA-125 (normal < 35 IU/mL) was found to be increased: 118.0 ± 147.1 IU/mL so was the mean diameter of cysts (cut off ≤ 5 cm): 48.6 ± 59.8 cm. No correlation was found between CA-125 levels and volume of ovarian cyst (r = 0.005, p = 0.680) for all subjects. Conclusions The lack of correlation between size of ovarian cysts and CA-125 levels provides a hint that the ovarian cyst epithelium does not directly express CA-125 and it may come from sites like the fallopian tube. Thus, raised level of CA-125 in benign ovarian cyst should be followed-up more closely, demanding assessment of fallopian tubes for early diagnosis of ovarian cancer. Also, algorithms can be explored to include size of ovarian cyst and CA 125 levels to predict ovarian cancer.

Clinical evaluation of salivary carbohydrate antigen 125 and leptin in controls and parotid tumours

Oral Diseases ◽  
2016 ◽  
Vol 22 (7) ◽  
pp. 630-638 ◽  
Author(s):  
K-Y Zhang ◽  
C-Y Liu ◽  
L Hua ◽  
S-L Wang ◽  
J Li
Keyword(s):  
Clinical Evaluation ◽  
Carbohydrate Antigen ◽  
Carbohydrate Antigen 125 ◽  
Parotid Tumours
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