scholarly journals Surface-Enhanced Transmission Mode Desorption Electrospray Ionization: Increasing the Specificity of Ambient Ionization Mass Spectrometric Analyses

2010 ◽  
Vol 82 (1) ◽  
pp. 16-18 ◽  
Author(s):  
Joseph E. Chipuk ◽  
Michael H. Gelb ◽  
Jennifer S. Brodbelt
Keyword(s):  
Electrospray Ionization ◽  
Desorption Electrospray Ionization ◽  
Ambient Ionization ◽  
Mass Spectrometric ◽  
Transmission Mode ◽  
Ionization Mass ◽  
Enhanced Transmission ◽  
Surface Enhanced

scholarly journals Trace detection of inorganic oxidants using desorption electrospray ionization (DESI) mass spectrometry

2011 ◽  
Vol 9 (5) ◽  
pp. 790-797 ◽  
Author(s):  
Ewa Sokol ◽  
Ayanna Jackson ◽  
R. Cooks
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Matrix Effects ◽  
Sodium Perchlorate ◽  
Desorption Electrospray Ionization ◽  
Surface Concentration ◽  
Ambient Ionization ◽  
Hydrocarbon Mixture ◽  
Ionization Mass ◽  
Trace Detection

AbstractDesorption electrospray ionization (DESI), an established ambient ionization method in mass spectrometry (MS) for the analysis of organic compounds, is applied here to trace detection of inorganic salts, including inorganic oxidants. In-situ surface analysis of targeted compounds, including nitrogen-, halogen- and sulfur-salts, down to sub-nanogram levels, was performed using DESI-MS. Successful experiments were carried out in both the negative and the positive ion modes; simple anions and cations as well as small cluster ions were observed. Various surfaces are examined and surface porosity effects were briefly explored. Absolute detection limits on porous polytetrafluoroethylene (PTFE) of 120 pg (surface concentration 0.07 ng mm−2) and 50 pg (surface concentration 0.03 ng mm−2), were achieved for sodium chlorate and sodium perchlorate, respectively. The compounds of interest were examined in the presence of a hydrocarbon mixture to assess matrix effects: only a two- or three-fold decrease in the target ion intensity was observed. Commercial fireworks were analyzed to determine perchlorate salts in complex mixtures. This work demonstrates the potential applicability of ambient ionization mass spectrometry to forensic investigations involving improvised explosives.

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