Rapid LC-MS Drug Metabolite Profiling Using Microsomal Enzyme Bioreactors in a Parallel Processing Format

Besnik Bajrami; Linlin Zhao; John B. Schenkman; James F. Rusling

doi:10.1021/ac9015853

Rapid LC-MS Drug Metabolite Profiling Using Microsomal Enzyme Bioreactors in a Parallel Processing Format

Analytical Chemistry ◽

10.1021/ac9015853 ◽

2009 ◽

Vol 81 (24) ◽

pp. 9921-9929 ◽

Cited By ~ 23

Author(s):

Besnik Bajrami ◽

Linlin Zhao ◽

John B. Schenkman ◽

James F. Rusling

Keyword(s):

Parallel Processing ◽

Metabolite Profiling ◽

Microsomal Enzyme ◽

Drug Metabolite

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Rapid LC-MS Drug Metabolite Profiling Using Microsomal Enzyme Bioreactors in a Parallel Processing Format

Analytical Chemistry ◽

10.1021/ac902800t ◽

2010 ◽

Vol 82 (2) ◽

pp. 762-762

Author(s):

Besnik Bajrami ◽

Linlin Zhao ◽

John B. Schenkman ◽

James F. Rusling

Keyword(s):

Parallel Processing ◽

Metabolite Profiling ◽

Microsomal Enzyme ◽

Drug Metabolite

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High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS)-Based Drug Metabolite Profiling

Methods in Molecular Biology - Metabolic Profiling ◽

10.1007/978-1-61737-985-7_10 ◽

2010 ◽

pp. 173-190 ◽

Cited By ~ 9

Author(s):

Ian D. Wilson

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Metabolite Profiling ◽

High Performance ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Drug Metabolite

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Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: Optimization of chromatographic peak capacity

Journal of Chromatography A ◽

10.1016/j.chroma.2014.11.037 ◽

2014 ◽

Vol 1374 ◽

pp. 122-133 ◽

Cited By ~ 7

Author(s):

Anne-Charlotte Dubbelman ◽

Filip Cuyckens ◽

Lieve Dillen ◽

Gerhard Gross ◽

Thomas Hankemeier ◽

...

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Metabolite Profiling ◽

High Performance ◽

Systematic Evaluation ◽

Peak Capacity ◽

Chromatographic Peak ◽

Drug Metabolite ◽

Chromatography Columns

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Development in Drug Metabolite Profiling (Part-I)

Current Drug Metabolism ◽

10.2174/138920022211211217114400 ◽

2021 ◽

Vol 22 (11) ◽

pp. 836-837

Author(s):

Jie Xing

Keyword(s):

Metabolite Profiling ◽

Drug Metabolite

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Evaluation of the use of UPLC-TOFMS with simultaneous [14C]-radioflow detection for drug metabolite profiling: Application to propranolol metabolites in rat urine

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2008.05.003 ◽

2008 ◽

Vol 48 (1) ◽

pp. 151-157 ◽

Cited By ~ 17

Author(s):

T.J. Athersuch ◽

R.L. Sison ◽

A.S.J. Kenyon ◽

J.A. Clarkson-Jones ◽

I.D. Wilson

Keyword(s):

Metabolite Profiling ◽

Rat Urine ◽

Drug Metabolite

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A New Workflow for Drug Metabolite Profiling by Utilizing Advanced Tribrid Mass Spectrometry and Data-Processing Techniques

Journal of the American Society for Mass Spectrometry ◽

10.1021/jasms.0c00436 ◽

2021 ◽

Author(s):

Qian Ruan ◽

Kate Comstock

Keyword(s):

Mass Spectrometry ◽

Data Processing ◽

Metabolite Profiling ◽

Drug Metabolite ◽

Processing Techniques

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In Vitro Drug Metabolite Profiling Using Hepatic S9 and Human Liver Microsomes

Optimization in Drug Discovery ◽

10.1385/1-59259-800-5:163 ◽

2004 ◽

pp. 163-184 ◽

Cited By ~ 9

Author(s):

Wu-Nan Wu ◽

Linda A. McKown

Keyword(s):

Metabolite Profiling ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Drug Metabolite

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Drug Metabolite Profiling and Identification by High-resolution Mass Spectrometry

Journal of Biological Chemistry ◽

10.1074/jbc.r110.200055 ◽

2011 ◽

Vol 286 (29) ◽

pp. 25419-25425 ◽

Cited By ~ 128

Author(s):

Mingshe Zhu ◽

Haiying Zhang ◽

W. Griffith Humphreys

Keyword(s):

Mass Spectrometry ◽

High Resolution ◽

Metabolite Profiling ◽

High Resolution Mass Spectrometry ◽

Drug Metabolite ◽

High Resolution Mass ◽

Resolution Mass

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Rapid drug metabolite profiling using fast liquid chromatography, automated multiple-stage mass spectrometry and receptor-binding

Journal of Chromatography A ◽

10.1016/s0021-9673(98)00956-x ◽

1999 ◽

Vol 831 (2) ◽

pp. 227-241 ◽

Cited By ~ 44

Author(s):

H.K Lim ◽

S Stellingweif ◽

S Sisenwine ◽

K.W Chan

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Receptor Binding ◽

Metabolite Profiling ◽

Drug Metabolite ◽

Fast Liquid Chromatography

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Nuclear Magnetic Resonance (NMR)-Based Drug Metabolite Profiling

Methods in Molecular Biology - Metabolic Profiling ◽

10.1007/978-1-61737-985-7_18 ◽

2010 ◽

pp. 299-319 ◽

Cited By ~ 11

Author(s):

Eva M. Lenz

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Metabolite Profiling ◽

Drug Metabolite ◽

Nuclear Magnetic

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