Characterization of Oligosaccharides in Recombinant Tissue Plasminogen Activator Produced in Chinese Hamster Ovary Cells: Two Decades of Analytical Technology Development

Oleg V. Borisov; Matthew Field; Victor T. Ling; Reed J. Harris

doi:10.1021/ac901498k

Characterization of Oligosaccharides in Recombinant Tissue Plasminogen Activator Produced in Chinese Hamster Ovary Cells: Two Decades of Analytical Technology Development

Analytical Chemistry ◽

10.1021/ac901498k ◽

2009 ◽

Vol 81 (23) ◽

pp. 9744-9754 ◽

Cited By ~ 19

Author(s):

Oleg V. Borisov ◽

Matthew Field ◽

Victor T. Ling ◽

Reed J. Harris

Keyword(s):

Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Technology Development ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Recombinant Tissue Plasminogen Activator ◽

Ovary Cells ◽

Tissue Plasminogen ◽

Analytical Technology

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Engineering the Cellular Protein Secretory Pathway for Enhancement of Recombinant Tissue Plasminogen Activator Expression in Chinese Hamster Ovary Cells: Effects of CERT and XBP1s Genes

Journal of Microbiology and Biotechnology ◽

10.4014/jmb.1302.02035 ◽

2013 ◽

Vol 23 (8) ◽

pp. 1116-1122 ◽

Cited By ~ 17

Author(s):

Azam Rahimpour

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Secretory Pathway ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Recombinant Tissue Plasminogen Activator ◽

Cellular Protein ◽

Ovary Cells ◽

Tissue Plasminogen

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Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture

PLoS ONE ◽

10.1371/journal.pone.0151529 ◽

2016 ◽

Vol 11 (3) ◽

pp. e0151529 ◽

Cited By ~ 28

Author(s):

Andrea Bedoya-López ◽

Karel Estrada ◽

Alejandro Sanchez-Flores ◽

Octavio T. Ramírez ◽

Claudia Altamirano ◽

...

Keyword(s):

Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Human Tissue ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Effect Of Temperature ◽

Ovary Cells ◽

Tissue Plasminogen ◽

Temperature Downshift ◽

Transcriptomic Responses

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Characterization of the oligosaccharide structures on a recombinant tissue-type plasminogen activator analog synthesized in chinese hamster ovary cells

Fibrinolysis and Proteolysis ◽

10.1016/0268-9499(94)90029-9 ◽

1994 ◽

Vol 8 (1) ◽

pp. 31-41 ◽

Cited By ~ 1

Author(s):

P.A. Aeed ◽

D.M. Guido ◽

W.R. Mathews ◽

J.W. Leone ◽

Å.P. Elhammer

Keyword(s):

Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Tissue Type ◽

Ovary Cells ◽

Tissue Type Plasminogen Activator ◽

Type Plasminogen Activator ◽

Oligosaccharide Structures

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Tissue Plasminogen Activator Coexpressed in Chinese Hamster Ovary Cells with .alpha.(2,6)-Sialyltransferase Contains NeuAc.alpha.(2,6)Gal.beta.(1,4)Glc-N-AcR Linkages

Biotechnology Progress ◽

10.1021/bp00033a015 ◽

1995 ◽

Vol 11 (3) ◽

pp. 348-351 ◽

Cited By ~ 49

Author(s):

Sherrill L. Minch ◽

Pauli T. Kallio ◽

James E. Bailey

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Tissue Plasminogen

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Effect of vitreoscilla hemoglobin expression on growth and specific tissue plasminogen activator productivity in recombinant chinese hamster ovary cells

Biotechnology and Bioengineering ◽

10.1002/bit.260441114 ◽

1994 ◽

Vol 44 (11) ◽

pp. 1367-1370 ◽

Cited By ~ 35

Author(s):

Girish J. Pendse ◽

James E. Bailey

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Vitreoscilla Hemoglobin ◽

Ovary Cells ◽

Tissue Plasminogen ◽

Specific Tissue

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Carbohydrate Structures of Human Tissue Plasminogen Activator Expressed in Chinese Hamster Ovary Cells

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)71649-9 ◽

1989 ◽

Vol 264 (24) ◽

pp. 14100-14111 ◽

Cited By ~ 6

Author(s):

M W Spellman ◽

L J Basa ◽

C K Leonard ◽

J A Chakel ◽

J V O'Connor ◽

...

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Human Tissue ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Tissue Plasminogen

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Carbohydrate structures of a human tissue plasminogen activator variant expressed in recombinant Chinese hamster ovary cells

FEBS Letters ◽

10.1016/0014-5793(90)80361-l ◽

1990 ◽

Vol 271 (1-2) ◽

pp. 14-18 ◽

Cited By ~ 32

Author(s):

Manfred Nimtz ◽

Gabriele Noll ◽

Eric-Paul Pâques ◽

Harald S. Conradt

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Human Tissue ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Tissue Plasminogen

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Effects of shifts up and down in osmotic pressure on production of tissue plasminogen activator by Chinese hamster ovary cells in suspension

Journal of Bioscience and Bioengineering ◽

10.1016/s1389-1723(01)80282-6 ◽

2001 ◽

Vol 91 (5) ◽

pp. 509-514 ◽

Cited By ~ 13

Author(s):

Mutsumi Takagi ◽

Tetsuhiro Moriyama ◽

Toshiomi Yoshida

Keyword(s):

Osmotic Pressure ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Tissue Plasminogen

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Proteomics Profiling of Chimeric-Truncated Tissue Plasminogen activator Producing- Chinese Hamster Ovary Cells Cultivated in a Chemically Defined Medium Supplemented with Protein Hydrolysates

Iranian Biomedical Journal ◽

10.18869/acadpub.ibj.21.3.154 ◽

2017 ◽

Vol 21 (3) ◽

pp. 154-166 ◽

Cited By ~ 1

Author(s):

Bahareh Azarian ◽

Seyedeh Matin Sajedin ◽

Amin Azimi ◽

Mozhgan Raigani ◽

Behrouz Vaziri ◽

...

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Defined Medium ◽

Protein Hydrolysates ◽

Chemically Defined Medium ◽

Ovary Cells ◽

Tissue Plasminogen

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A variant of tissue plasminogen activator (t-PA) comprised of the Kringle 2 and the protease domain shows a significant difference in the in vitro rate of plasmin formation as compared to the recombinant human t-PA from transformed chinese hamster ovary cells

Fibrinolysis and Proteolysis ◽

10.1016/0268-9499(93)90060-9 ◽

1993 ◽

Vol 7 (6) ◽

pp. 365-372 ◽

Cited By ~ 14

Author(s):

U. Kohnert ◽

B. Horsch ◽

S. Fischer

Keyword(s):

Plasminogen Activator ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Protease Domain ◽

Ovary Cells ◽

Significant Difference ◽

Tissue Plasminogen ◽

Kringle 2

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