Dual Labeling of Metabolites for Metabolome Analysis (DLEMMA): A New Approach for the Identification and Relative Quantification of Metabolites by Means of Dual Isotope Labeling and Liquid Chromatography−Mass Spectrometry

Liron Feldberg; Ilya Venger; Sergey Malitsky; Ilana Rogachev; Asaph Aharoni

doi:10.1021/ac901495a

Dual Labeling of Metabolites for Metabolome Analysis (DLEMMA): A New Approach for the Identification and Relative Quantification of Metabolites by Means of Dual Isotope Labeling and Liquid Chromatography−Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac901495a ◽

2009 ◽

Vol 81 (22) ◽

pp. 9257-9266 ◽

Cited By ~ 30

Author(s):

Liron Feldberg ◽

Ilya Venger ◽

Sergey Malitsky ◽

Ilana Rogachev ◽

Asaph Aharoni

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Isotope Labeling ◽

Relative Quantification ◽

Liquid Chromatography Mass Spectrometry ◽

Metabolome Analysis ◽

New Approach ◽

Dual Isotope ◽

Chromatography Mass Spectrometry

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Differential Isotope Labeling by Permethylation and Reversed-Phase Liquid Chromatography–Mass Spectrometry for Relative Quantification of Intact Neutral Glycolipids in Mammalian Cells

Analytical Chemistry ◽

10.1021/acs.analchem.9b01206 ◽

2019 ◽

Vol 91 (15) ◽

pp. 9673-9681 ◽

Cited By ~ 3

Author(s):

Rodell C. Barrientos ◽

Qibin Zhang

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Mammalian Cells ◽

Isotope Labeling ◽

Reversed Phase ◽

Relative Quantification ◽

Liquid Chromatography Mass Spectrometry ◽

Reversed Phase Liquid Chromatography ◽

Chromatography Mass Spectrometry ◽

Phase Liquid

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Quantitative Metabolome Analysis Based on Chromatographic Peak Reconstruction in Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.5b01434 ◽

2015 ◽

Vol 87 (14) ◽

pp. 7011-7016 ◽

Cited By ~ 47

Author(s):

Tao Huan ◽

Liang Li

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Isotope Labeling ◽

Chromatographic Peak ◽

Liquid Chromatography Mass Spectrometry ◽

Metabolome Analysis ◽

Chromatography Mass Spectrometry ◽

Chemical Isotope Labeling

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5-Diethylamino-naphthalene-1-sulfonyl Chloride (DensCl): A Novel Triplex Isotope Labeling Reagent for Quantitative Metabolome Analysis by Liquid Chromatography Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac403000n ◽

2013 ◽

Vol 85 (23) ◽

pp. 11532-11539 ◽

Cited By ~ 39

Author(s):

Ruokun Zhou ◽

Kevin Guo ◽

Liang Li

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Isotope Labeling ◽

Sulfonyl Chloride ◽

Liquid Chromatography Mass Spectrometry ◽

Metabolome Analysis ◽

Chromatography Mass Spectrometry

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A structure–guided screening strategy for the discovery and identification of potential gibberellins from plant samples using liquid chromatography–mass spectrometry assisted by chemical isotope labeling

Analytica Chimica Acta ◽

10.1016/j.aca.2021.338505 ◽

2021 ◽

Vol 1163 ◽

pp. 338505

Author(s):

Wen-Jing Cai ◽

Chen Zeng ◽

Xiao-Yun Zhang ◽

Tiantian Ye ◽

Yu-Qi Feng

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Isotope Labeling ◽

Screening Strategy ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Plant Samples ◽

Chemical Isotope Labeling

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Profiling of potential brassinosteroids in different tissues of rape flower by stable isotope labeling - liquid chromatography/mass spectrometry analysis

Analytica Chimica Acta ◽

10.1016/j.aca.2017.08.038 ◽

2018 ◽

Vol 1037 ◽

pp. 55-62 ◽

Cited By ~ 8

Author(s):

Lei Yu ◽

Tiantian Ye ◽

Ya-Li Bai ◽

Wen-Jing Cai ◽

Jun Ding ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Stable Isotope ◽

Isotope Labeling ◽

Stable Isotope Labeling ◽

Mass Spectrometry Analysis ◽

Liquid Chromatography Mass Spectrometry ◽

Spectrometry Analysis ◽

Chromatography Mass Spectrometry ◽

Different Tissues

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Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2019.00210 ◽

2019 ◽

Vol 7 ◽

Cited By ~ 10

Author(s):

Dominik Wigger ◽

Erich Gulbins ◽

Burkhard Kleuser ◽

Fabian Schumacher

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Stable Isotope ◽

Isotope Labeling ◽

De Novo ◽

Stable Isotope Labeling ◽

Liquid Chromatography Mass Spectrometry ◽

De Novo Synthesis ◽

Chromatography Mass Spectrometry

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Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers

Journal of Food and Drug Analysis ◽

10.1016/j.jfda.2018.11.008 ◽

2019 ◽

Vol 27 (2) ◽

pp. 460-474 ◽

Cited By ~ 3

Author(s):

Yi-Ting Chen ◽

Hsin-Chien Huang ◽

Ya-Ju Hsieh ◽

Shu-Hsuan Fu ◽

Liang Li ◽

...

Keyword(s):

Mass Spectrometry ◽

Bladder Cancer ◽

Liquid Chromatography ◽

Isotope Labeling ◽

Cancer Biomarkers ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry

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Comparative quantification and identification of phosphoproteins using stable isotope labeling and liquid chromatography/mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/1097-0231(20000930)14:18<1677::aid-rcm84>3.0.co;2-n ◽

2000 ◽

Vol 14 (18) ◽

pp. 1677-1681 ◽

Cited By ~ 73

Author(s):

Wolfram Weckwerth ◽

Lothar Willmitzer ◽

Oliver Fiehn

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Stable Isotope ◽

Isotope Labeling ◽

Stable Isotope Labeling ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry

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Development of chemical isotope labeling liquid chromatography mass spectrometry for silkworm hemolymph metabolomics

Analytica Chimica Acta ◽

10.1016/j.aca.2016.06.004 ◽

2016 ◽

Vol 942 ◽

pp. 1-11 ◽

Cited By ~ 4

Author(s):

Weifeng Shen ◽

Wei Han ◽

Yunong Li ◽

Zhiqi Meng ◽

Leiming Cai ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Isotope Labeling ◽

Liquid Chromatography Mass Spectrometry ◽

Silkworm Hemolymph ◽

Chromatography Mass Spectrometry ◽

Chemical Isotope Labeling

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4-Phenylaminomethyl-Benzeneboric Acid Modified Tip Extraction for Determination of Brassinosteroids in Plant Tissues by Stable Isotope Labeling–Liquid Chromatography–Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.5b03720 ◽

2015 ◽

Vol 88 (2) ◽

pp. 1286-1293 ◽

Cited By ~ 41

Author(s):

Lei Yu ◽

Jun Ding ◽

Ya-Lan Wang ◽

Ping Liu ◽

Yu-Qi Feng

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Stable Isotope ◽

Isotope Labeling ◽

Stable Isotope Labeling ◽

Plant Tissues ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry

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