Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS

2009 ◽  
Vol 81 (15) ◽  
pp. 6364-6373 ◽  
Author(s):  
Cédric Atmanene ◽  
Elsa Wagner-Rousset ◽  
Martine Malissard ◽  
Bertrand Chol ◽  
Alain Robert ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Immune Complexes ◽  
Lead Optimization ◽  
Esi Ms ◽  
Therapeutic Monoclonal Antibody

An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants

2022 ◽  
Author(s):  
Tian Xu ◽  
Linjie Han ◽  
Alayna M. George Thompson ◽  
Liangliang Sun
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
High Resolution ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Spectrometry Method ◽  
Mass Spectrometry Method ◽  
Charge Variants

Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for...

scholarly journals Detailed Characterization of Monoclonal Antibody Receptor Interaction Using Affinity Liquid Chromatography Hyphenated to Native Mass Spectrometry

2017 ◽  
Vol 89 (10) ◽  
pp. 5404-5412 ◽  
Author(s):  
Rabah Gahoual ◽  
Anna-Katharina Heidenreich ◽  
Govert W. Somsen ◽  
Patrick Bulau ◽  
Dietmar Reusch ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Liquid Chromatography ◽  
Native Mass Spectrometry ◽  
Receptor Interaction ◽  
Detailed Characterization
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