Label-Free Highly Sensitive Detection of Proteins in Aqueous Solutions Using Surface-Enhanced Raman Scattering

2009 ◽  
Vol 81 (9) ◽  
pp. 3329-3333 ◽  
Author(s):  
Xiao X. Han ◽  
Genin Gary Huang ◽  
Bing Zhao ◽  
Yukihiro Ozaki
Keyword(s):  
Raman Scattering ◽  
Aqueous Solutions ◽  
Surface Enhanced Raman Scattering ◽  
Sensitive Detection ◽  
Label Free ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Highly Sensitive Detection

Highly sensitive detection of paclitaxel by surface-enhanced Raman scattering

2015 ◽  
Vol 17 (11) ◽  
pp. 114019 ◽  
Author(s):  
Maximilien Cottat ◽  
Nathalie Lidgi-Guigui ◽  
Frédéric Hamouda ◽  
Bernard Bartenlian ◽  
Divya Venkataraman ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Sensitive Detection ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Highly Sensitive Detection

Highly Sensitive Detection of Blood by Surface Enhanced Raman Scattering,,

2013 ◽  
Vol 58 (3) ◽  
pp. 753-756 ◽  
Author(s):  
Samantha Boyd ◽  
Massimo F. Bertino ◽  
Dexian Ye ◽  
Lauren S. White ◽  
Sarah J. Seashols
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Sensitive Detection ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Highly Sensitive Detection

scholarly journals Highly Sensitive Detection and Differentiation of Endotoxins Derived from Bacterial Pathogens by Surface-Enhanced Raman Scattering

Biosensors ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 234
Author(s):  
Xiaomeng Wu ◽  
Yiping Zhao ◽  
Susu M. Zughaier
Keyword(s):  
Raman Scattering ◽  
Lipid A ◽  
Surface Enhanced Raman Scattering ◽  
Sensitive Detection ◽  
Bacterial Endotoxins ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Highly Sensitive Detection

Bacterial endotoxins, as major components of Gram-negative bacterial outer membrane leaflets and a well-characterized TLR4-MD-2 ligand, are lipopolysaccharides (LPSs) that are constantly shed from bacteria during growth and infection. For the first time, we report that unique surface-enhanced Raman scattering (SERS) spectra of enteric LPSs from E. coli, S. typhimurium, S. minnesota, V. cholerae, Rhizobium species R. CE3, and R. NGR, as well as Neisseria meningitidis endotoxin structures, LPSs, lipid A, and KDO2-lipid A can be obtained. The characteristic peaks of the SERS spectra reveal that most of the tested LPS structures are from lipids and saccharides, i.e., the major components of LPSs, and these spectra can be successfully used to differentiate between endotoxins with principal components analysis. In addition, all the LPS samples here are measured at a concentration of 10 nmole/mL, which corresponds to their relevant pathophysiological concentrations in clinical infections. This study demonstrates that LPSs can be used as biomarkers for the highly sensitive detection of bacteria using SERS-based methods.

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