scholarly journals Enhanced Ion Utilization Efficiency Using an Electrodynamic Ion Funnel Trap as an Injection Mechanism for Ion Mobility Spectrometry

2008 ◽  
Vol 80 (3) ◽  
pp. 612-623 ◽  
Author(s):  
Brian H. Clowers ◽  
Yehia M. Ibrahim ◽  
David C. Prior ◽  
William F. Danielson ◽  
Mikhail E. Belov ◽  
...  
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Utilization Efficiency ◽  
Funnel Trap ◽  
Injection Mechanism ◽  
Ion Funnel

scholarly journals Improving Ion Mobility Measurement Sensitivity by Utilizing Helium in an Ion Funnel Trap

2014 ◽  
Vol 86 (11) ◽  
pp. 5295-5299 ◽  
Author(s):  
Yehia M. Ibrahim ◽  
Sandilya V. B. Garimella ◽  
Aleksey V. Tolmachev ◽  
Erin S. Baker ◽  
Richard D. Smith
Keyword(s):  
Ion Mobility ◽  
Measurement Sensitivity ◽  
Funnel Trap ◽  
Mobility Measurement ◽  
Ion Funnel

scholarly journals Ion Mobility Spectrometry with High Ion Utilization Efficiency Using Traveling Wave-Based Structures for Lossless Ion Manipulations

2020 ◽  
Vol 92 (22) ◽  
pp. 14930-14938
Author(s):  
Ailin Li ◽  
Gabe Nagy ◽  
Christopher R. Conant ◽  
Randolph V. Norheim ◽  
Joon Yong Lee ◽  
...  
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Traveling Wave ◽  
Utilization Efficiency

scholarly journals High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces

2005 ◽  
Vol 77 (10) ◽  
pp. 3330-3339 ◽  
Author(s):  
Keqi Tang ◽  
Alexandre A. Shvartsburg ◽  
Hak-No Lee ◽  
David C. Prior ◽  
Michael A. Buschbach ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
High Sensitivity ◽  
Ion Funnel

Influence of multiplexing conditions on artefact signal and the signal-to-noise ratio in the decoded data in Hadamard transform ion mobility spectrometry

2020 ◽  
Vol 26 (3) ◽  
pp. 204-212
Author(s):  
Anastasia Sarycheva ◽  
Alexey Adamov ◽  
Sergey S Poteshin ◽  
Sergey S Lagunov ◽  
Alexey A Sysoev
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Signal To Noise Ratio ◽  
Random Noise ◽  
Utilization Efficiency ◽  
Hadamard Transform ◽  
Signal Averaging ◽  
Signal To Noise ◽  
Pseudorandom Sequences ◽  
Noise Ratio

In Hadamard transform ion mobility spectrometry (HT IMS), the signal-to-noise ratio is always lower for non-modified pseudorandom sequences than for modified sequences. Since the use of non-modified modulating pseudorandom sequences is strategically preferable from a duty cycle standpoint, we investigated the change in the interference signal when transitioning from non-modified modulating sequences to sequences modified by the addition of 1,3,5 and 7 zeros. The interfering signal in HT IMS with modified pseudorandom sequences was shown to be mainly random noise for all the cases except for modifying by incorporation of 1 zero. For standard samples of tetraalkylammonium halides, modulation by non-modified pseudorandom sequences is beneficial in the case of small numbers of averaged spectra (below ∼40 averaged spectra compared to any modified pseudorandom sequences except for 1 zero modified and below ∼200 averaged spectra compared to signal averaging ion mobility spectrometry) and worsens the signal-to-noise ratio in the case of large numbers of averaged spectra. Contrarily, modulation by modified pseudorandom sequences is beneficial for any number of averaged spectra, except for very small ones (below 15 averaged spectra compared to modulation by non-modified sequences). Pseudorandom sequence modified with 1 zero incorporation is beneficial in the case of below ∼400 averaged spectra compared to any modified and non-modified pseudorandom sequences. The signal-to-noise ratio in conventional signal averaging mode ion mobility spectrometry is affected by random noise, whereas the HT IMS with non-modified pseudorandom sequences was demonstrated to be primarily affected by a systematic noise-like artefact signal. Because noise-like artefact signals were found to be reproducible, predicting models for interference signals could be generated to improve signal-to-noise ratio. This is significant because non-modified modulating sequences are limited by their poor signal-to-noise ratio. This improvement would increase the viability of non-modified modulating sequences which are preferred because of their higher sample utilization efficiency.

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