Determination of Aldehydes in the Presence of Acids, Acetals, and Ketones, Using a Silver Oxide-tert-Butylamine Complex.

1964 ◽  
Vol 36 (4) ◽  
pp. 934-935 ◽  
Author(s):  
J. A. Mayes ◽  
E. J. Kuchar ◽  
Sidney. Siggia
Keyword(s):  
Silver Oxide ◽  
Tert Butylamine

scholarly journals Validation of an Oil-in-Water Microemulsion Liquid Chromatography Method for Analysis of Perindopril tert-Butylamine and Its Impurities

2011 ◽  
Vol 94 (3) ◽  
pp. 723-734 ◽  
Author(s):  
Marija Mašković ◽  
Yannis Dotsikas ◽  
Anđelija Malenović ◽  
Biljana Jančić-Stojanović ◽  
Darko Ivanović ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
Method Validation ◽  
Dihydrogen Phosphate ◽  
Mobile Phase Flow Rate ◽  
Pharmaceutical Dosage Form ◽  
Validation Parameters ◽  
Tert Butylamine ◽  
Microemulsion Liquid Chromatography

Abstract This paper describes the development and validation of a microemulsion liquid chromatography (MELC) method for simultaneous determination of perindopril tert-butylamine and its impurities in bulk active substances and the pharmaceutical dosage form of tablets. An appropriate resolution with reasonable retention times was obtained for a microemulsion containing 0.24% (w/v) butyl acetate, 0.30% (w/v) ethyl acetate, 2% (w/v) sodium dodecyl sulfate, 7.75% (w/v) n-butanol, and 20.0 mM potassium dihydrogen phosphate, the pH of which was adjusted to 3.70 with 85% orthophosphoric acid. Separations were performed on a Nucleosil 120-5 butyl modified (C4), 250 × 4 mm, 5 μm particle size silica column at 40°C, with a mobile phase flow rate of 1.25 mL/min. UV detection was performed at 254 nm. The established method was subjected to method validation, and required validation parameters were defined. Robustness testing, an important part of method validation, was performed as well. Since robustness validation can be conducted using different experimental designs, the Plackett-Burman design was applied due to its possibility of testing many factors at the same time. The validated MELC method was found to be suitable for the simultaneous determination of perindopril tert-butylamine and its impurities in pharmaceuticals.

Simple and Rapid Spectrophotometry Method for Determination of Adrenaline and Isoprenaline

1988 ◽  
Vol 71 (4) ◽  
pp. 764-767
Author(s):  
Salwa R El-Shabouri ◽  
Samiha A Hussein ◽  
Abdel-Alim M Abdel-Alim
Keyword(s):  
Aqueous Solution ◽  
Sodium Chloride ◽  
Oxidation Reaction ◽  
Silver Oxide ◽  
Oxidative Degradation ◽  
Side Chain ◽  
Sodium Metabisulfite ◽  
Specific Method ◽  
Reaction Conditions

Abstract A simple, rapid, and specific method for determination of adrenaline bitartrate and isoprenaline sulfate was developed. The method is based on the oxidation reaction in aqueous solution of either adrenaline bitartrate or isoprenaline sulfate in the presence of silver oxide to give a red aminochrome measurable at 490 nm. The color is stable for 2 h. Beer's law is valid within a concentration range of 5-80 ng/ mL for each drug. All variables were studied to optimize the reaction conditions. The method is specific for catecholamine drugs having a secondary amine in the side chain. Other catecholamines such as orciprenaline and noradrenaline do not interfere, and no interference was observed in the presence of common pharmaceutical adjuvants. Interference due to sodium metabisulfite and sodium chloride was circumvented. The validity of the method was tested by analyzing adrenaline injections and isoprenaline tablets. Good recoveries were obtained for these preparations. The results were comparable to those obtained by official procedures. The proposed method is also recommended as a stability indicating assay for oxidative degradation of both drugs.

scholarly journals Determination of residual sodium content in silver and silver oxide composite materials

Analusis ◽  
2000 ◽  
Vol 28 (4) ◽  
pp. 302-307 ◽  
Author(s):  
R. Vivier ◽  
L. Muhr ◽  
H. Muhr ◽  
E. Plasari
Keyword(s):  
Composite Materials ◽  
Silver Oxide ◽  
Sodium Content ◽  
Oxide Composite

Determination of the Adsorption Sites of tert-Butylamine Molecules on a Cu(111) Surface with a Co-Adsorbed CO Monolayer

2009 ◽  
Vol 25 (08) ◽  
pp. 1485-1489
Author(s):  
CHEN Yu-Min ◽  
◽  
◽  
DENG Ke ◽  
QIU Xiao-Hui ◽  
...  
Keyword(s):  
Adsorption Sites ◽  
Tert Butylamine ◽  
Adsorbed Co
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