Determination of Phenylacetic Acid and Phenylacetamides in Samples from Penicillin Fermentations

1954 ◽  
Vol 26 (9) ◽  
pp. 1432-1438 ◽  
Author(s):  
S. C. Pan ◽  
David. Perlman
Keyword(s):  
Phenylacetic Acid

Simple HPLC Method for Routine Determination of Urinary Phenylacetic Acid Excretion

1993 ◽  
Vol 16 (3) ◽  
pp. 733-741
Author(s):  
E. Griesemann ◽  
S. Bouquet ◽  
M. C. Perault ◽  
S. Favreliere ◽  
L. Barrier ◽  
...  
Keyword(s):  
Phenylacetic Acid ◽  
Hplc Method ◽  
Acid Excretion

Mass-fragmentographic determination of catecholamine metabolites in amniotic fluid and its possible clinical usefulness.

1978 ◽  
Vol 24 (11) ◽  
pp. 1899-1902 ◽  
Author(s):  
F A Muskiet ◽  
H J Jeuring ◽  
G T Nagel ◽  
H W de Bruyn ◽  
B G Wolthers
Keyword(s):  
Amniotic Fluid ◽  
Gestational Age ◽  
Phenylacetic Acid ◽  
Mass Fragmentography ◽  
Absolute Concentration ◽  
Creatinine Concentration ◽  
Internal Standards ◽  
Catecholamine Metabolites ◽  
Congenital Neuroblastoma

Abstract We describe the determination of 3-methoxy-4-hydroxy-phenylacetic acid, 3-methoxy-4-hydroxyphenylamandelic acid, and 3-methoxy-4-hydroxyphenylethylene glycol in amniotic fluid by means of mass fragmentography, with use of deuterated internal standards. The results expressed in terms of absolute concentration and creatinine concentration, are given as a function of gestational age. In the 15th to 17th week, concentrations in amniotic fluid are a reflection of those in the mother's serum, whereas in the 32nd to 40th week, these concentrations, expressed in terms of creatinine, are similar to those found in the urine of newborns. We discuss the possible usefulness of the determination of catecholamine metabolites in amniotic fluid in the diagnosis of congenital neuroblastoma, maternal pheochromocytoma, and underdevelopment.

scholarly journals Urinary aromatic acid excretion by fed and fasted sheep in relation to protein metabolism in the rumen

1973 ◽  
Vol 30 (2) ◽  
pp. 251-267 ◽  
Author(s):  
A. K. Martin
Keyword(s):  
Benzoic Acid ◽  
Urinary Excretion ◽  
Phenylacetic Acid ◽  
Acid Output ◽  
Starvation Period ◽  
Regression Equations ◽  
Abomasal Infusion ◽  
Prolonged Retention ◽  
Field Beans

1. Two adult wether sheep were maintained on a diet of hay and two on a diet of dried grass for 3 weeks before starvation for a period of 10 d. Urinary excretion of the following acids was determined when the animals were fed and when they were fasted: total diethyl ethersoluble acids of hydrolysed and unhydrolysed urine, hippuric acid, benzoic acid and phenylacetic acid. By the 5th day of fasting, urinary output of all acids had attained stable levels that did not change during the remaining starvation period. The output of all urine fractions except phenylacetic acid declined rapidly during the first 4 d of fasting: phenylacetic acid output by all sheep increased to a maximum during the first 4 d of fast and then declined to stable values (0·42–0·73 g/24 h) which were greater than those observed when the sheep were fed. It is concluded that prolonged retention of food and microbial residues in the digestive tract is responsible for the large output of phenylacetic acid in the urine of fasted sheep.2. Solutions of casein which supplied between 6·3. and 26·5 g nitrogen/24 h were infused into the rumens (fifteen experiments) or abomasums (sixteen experiments) of eight adult wether sheep. Ruminal infusions of casein caused increments in the urinary excretion of diethyl ethersoluble acids and phenylacetic acid. Both these increments were described by linear regression equations (P < 0·001), the coefficients of which showed that 284 ± 44 and 220 ± 21 mg benzoic acid equivalent were excreted as diethyl ether-soluble acids and phenylacetic acid respectively per g casein N infused. The phenylacetic acid excreted was equivalent to 95% of the phenylalanine of the infused casein. No increments in urinary benzoic acid were observed. One sheep scoured when it was given an abomasal infusion of casein. This was the only animal to show any increment in urinary aromatic acids when casein was infused into the abomasum.3. When four sheep were given two rations containing an excess of carbohydrate as sugarbeet pulp or rolled barley, 11 and 16% respectively of their phenylalanine intakes were excreted in the urine as phenylacetic acid. When the same sheep were given two rations containing an excess of N as linseed meal or field beans, 51 and 59% respectively of their phenylalanine intakes appeared in the urine as phenylacetic acid.4. Methods for the determination of creatinine, and of benzoic, phenylacetic, 3-phenylpropionic, cinnamic, hippuric and phenaceturic acids are described.5. It is suggested that the amount of phenylacetic acid excreted in the urine is a measure of the equilibrium occurring in the rumen between catabolism of phenylalanine and reutilization of the products of catabolism for phenylalanine synthesis.

ChemInform Abstract: Determination of Enantiomeric Purity of Tertiary Amines by 1H NMR of α-Methoxy-α-(trifluoromethyl)phenylacetic Acid Complexes.

ChemInform ◽  
1987 ◽  
Vol 18 (13) ◽  
Author(s):  
F. J. JUN. VILLANI ◽  
M. J. COSTANZO ◽  
R. R. INNERS ◽  
M. S. MUTTER ◽  
D. E. MCCLURE
Keyword(s):  
1H Nmr ◽  
Phenylacetic Acid ◽  
Enantiomeric Purity ◽  
Tertiary Amines

Semiquantitative determination of a phenylacetic acid impurity in samples of phenylmalonic acid

1973 ◽  
Vol 7 (1) ◽  
pp. 49-50
Author(s):  
V. B. Korchagin ◽  
L. I. Serova ◽  
V. A. Volkova ◽  
N. I. Kotova ◽  
S. P. Kurakina ◽  
...  
Keyword(s):  
Phenylacetic Acid ◽  
Semiquantitative Determination ◽  
Phenylmalonic Acid ◽  
Acid Impurity

Gas Chromatographic ? Mass Spectrometric Determination of Phenylacetic Acid in Human Blood

2004 ◽  
Vol 94 (9-10) ◽  
pp. 715-719 ◽  
Author(s):  
Giovanna Mangani ◽  
Franco Canestrari ◽  
Arnaldo Berloni ◽  
Michela Maione ◽  
Silvia Pagliarani ◽  
...  
Keyword(s):  
Human Blood ◽  
Phenylacetic Acid ◽  
Mass Spectrometric ◽  
Mass Spectrometric Determination ◽  
Chromatographic Mass
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