DNAzyme-Based Plasmonic Nanomachine for Ultrasensitive Selective Surface-Enhanced Raman Scattering Detection of Lead Ions via a Particle-on-a-Film Hot Spot Construction

2014 ◽  
Vol 86 (23) ◽  
pp. 11494-11497 ◽  
Author(s):  
Cuicui Fu ◽  
Weiqing Xu ◽  
Hailong Wang ◽  
Han Ding ◽  
Lijia Liang ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Hot Spot ◽  
Surface Enhanced Raman Scattering ◽  
Lead Ions ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Novel Ag/Au/Pt trimetallic nanocages used with surface-enhanced Raman scattering for trace fluorescent dye detection

2014 ◽  
Vol 2 (34) ◽  
pp. 5550-5557 ◽  
Author(s):  
Tran Thi Bich Quyen ◽  
Wei-Nien Su ◽  
Ching-Hsiang Chen ◽  
John Rick ◽  
Jyong-Yue Liu ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Hot Spot ◽  
Surface Enhanced Raman Scattering ◽  
Signal Enhancement ◽  
Fluorescent Dye ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Hot Spot Formation ◽  
Spot Formation

Trimetallic nanocages possess inter-metallic synergies among elements and are able to generate significant SERS signal enhancement due to “hot spot” formation.

One-pot synthesis of gold nanodimers and their use as surface-enhanced Raman scattering tags

2016 ◽  
Vol 40 (9) ◽  
pp. 7299-7302 ◽  
Author(s):  
Noelia Vilar-Vidal ◽  
Sébastien Bonhommeau ◽  
David Talaga ◽  
Serge Ravaine
Keyword(s):  
Raman Scattering ◽  
Hot Spot ◽  
Surface Enhanced Raman Scattering ◽  
One Pot ◽  
One Pot Synthesis ◽  
Surface Enhanced ◽  
Enhancement Factors ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Gold dimers consisting of 40 nm-diameter nanospheres show enhancement factors as high as ∼1.8 × 107at the hot-spot level.

scholarly journals Rapid and sensitive biomarker detection using molecular imprinting polymer hydrogel and surface-enhanced Raman scattering

2018 ◽  
Vol 5 (1) ◽  
pp. 171488 ◽  
Author(s):  
Shaona Chen ◽  
Lijing Dong ◽  
Min Yan ◽  
Zhongxu Dai ◽  
Chenghua Sun ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Hot Spot ◽  
High Sensitivity ◽  
Surface Enhanced Raman Scattering ◽  
Test Time ◽  
Time Saving ◽  
Plasmonic Material ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Biomarkers are important biochemical indicators, which could be used for identification, early diagnosis and monitoring of diseases during the course of treatment. However, biomarker diagnosis has some shortcomings such as requiring a large amount of samples, long test time and high cost, which seriously influences the correctness and timely treatment to patients. Here, a relatively fast and efficient plasmonic hot spot-localized surface imprinting of Ag spheres using biomarker template immobilization and hydrogel copolymerization is described. The technique takes a fine control of the imprinting process at the nanometre scale and provides a biosensor with high sensitivity. Proof of the opinion is established by detection of biomarker using surface-enhanced Raman scattering (SERS) spectroscopy. This work represents a valuable step towards SERS with biomarkers for cost-saving and time-saving diagnostic assay. It is expected that the new surface imprinted hydrogel plasmonic material can drive possibilities in advancing application of biomarkers in plasmonic biosensors.

scholarly journals Silica-coated dimers of silver nanospheres as surface-enhanced Raman scattering tags for imaging cancer cells

2013 ◽  
Vol 3 (3) ◽  
pp. 20120092 ◽  
Author(s):  
Xiaohu Xia ◽  
Weiyang Li ◽  
Yu Zhang ◽  
Younan Xia
Keyword(s):  
Raman Scattering ◽  
Cancer Cells ◽  
Hot Spot ◽  
High Sensitivity ◽  
Silica Coating ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Sers Tags

Surface-enhanced Raman scattering (SERS) tags have been actively explored as a multiplexing platform for sensitive detection of biomolecules. Here, we report a new type of SERS tags that was fabricated by sequentially functionalizing dimers made of 50 nm Ag nanospheres with 4-mercaptobenzoic acid as the Raman reporter molecule, silica coating as a protective shell and antibody as a targeting ligand. These dimer-based tags give highly enhanced and reproducible Raman signals owing to the presence of a well-defined SERS hot spot at the junction between two Ag nanospheres in the dimer. The SERS enhancement factor (EF) of an individual dimer tag supported on a glass slide can reach a level as high as 4.3 × 10 6 . In comparison, the EFs dropped to 2.8 × 10 5 and 8.7 × 10 5 , respectively, when Ag nanospheres and nanocubes with sizes similar to the spheres in the dimer were used to fabricate the tags using similar procedures. The SERS signals from aqueous suspensions of the dimer-based tags also showed high intensity and good stability. Potential use of the dimer-based tags was demonstrated by imaging cancer cells overexpressing HER2 receptors with good specificity and high sensitivity.

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