Characterizing Variability of In Vivo Raman Spectroscopic Properties of Different Anatomical Sites of Normal Colorectal Tissue towards Cancer Diagnosis at Colonoscopy

2014 ◽  
Vol 87 (2) ◽  
pp. 960-966 ◽  
Author(s):  
Mads Sylvest Bergholt ◽  
Wei Zheng ◽  
Kan Lin ◽  
Jianfeng Wang ◽  
Hongzhi Xu ◽  
...  
Keyword(s):  
Cancer Diagnosis ◽  
Spectroscopic Properties ◽  
Raman Spectroscopic ◽  
Colorectal Tissue ◽  
Normal Colorectal Tissue

Differentiation of Tumour from Normal Colorectal Tissue by SELDI-MS Protein Profiling

Endoscopy ◽  
2004 ◽  
Vol 36 (05) ◽  
Author(s):  
AM Lennon ◽  
D Stuart ◽  
AC Tan ◽  
E Fox ◽  
KS Sheahan ◽  
...  
Keyword(s):  
Protein Profiling ◽  
Colorectal Tissue ◽  
Normal Colorectal Tissue

Trends in Nanotechnology for in vivo Cancer Diagnosis: Products and Patents

2020 ◽  
Vol 26 (18) ◽  
pp. 2167-2181
Author(s):  
Tatielle do Nascimento ◽  
Melanie Tavares ◽  
Mariana S.S.B. Monteiro ◽  
Ralph Santos-Oliveira ◽  
Adriane R. Todeschini ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Quantum Dots ◽  
Magnetic Resonance ◽  
Metal Nanoparticles ◽  
Cancer Diagnosis ◽  
Imaging Techniques ◽  
Tumor Detection ◽  
Abnormal Growth ◽  
Pharmaceutical Nanotechnology

Background: Cancer is a set of diseases formed by abnormal growth of cells leading to the formation of the tumor. The diagnosis can be made through symptoms’ evaluation or imaging tests, however, the techniques are limited and the tumor detection may be late. Thus, pharmaceutical nanotechnology has emerged to optimize the cancer diagnosis through nanostructured contrast agent’s development. Objective: This review aims to identify commercialized nanomedicines and patents for cancer diagnosis. Methods: The databases used for scientific articles research were Pubmed, Science Direct, Scielo and Lilacs. Research on companies’ websites and articles for the recognition of commercial nanomedicines was performed. The Derwent tool was applied for patent research. Results: This article aimed to research on nanosystems based on nanoparticles, dendrimers, liposomes, composites and quantum dots, associated to imaging techniques. Commercialized products based on metal and composite nanoparticles, associated with magnetic resonance and computed tomography, have been observed. The research conducted through Derwent tool displayed a small number of patents using nanotechnology for cancer diagnosis. Among these patents, the most significant number was related to the use of systems based on metal nanoparticles, composites and quantum dots. Conclusion: Although few systems are found in the market and patented, nanotechnology appears as a promising field for the development of new nanosystems in order to optimize and accelerate the cancer diagnosis.

In Vivo Bladder Cancer Diagnosis by High-Volume Raman Spectroscopy

2010 ◽  
Vol 82 (14) ◽  
pp. 5993-5999 ◽  
Author(s):  
Ronald O. P. Draga ◽  
Matthijs C. M. Grimbergen ◽  
Peter L. M. Vijverberg ◽  
Christiaan F. P. van Swol ◽  
Trudy G. N. Jonges ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bladder Cancer ◽  
Cancer Diagnosis ◽  
High Volume

In vivo fluorescence imaging for cancer diagnosis using receptor-targeted epidermal growth factor-based nanoprobe

Biomaterials ◽  
2013 ◽  
Vol 34 (36) ◽  
pp. 9149-9159 ◽  
Author(s):  
Ju Hee Ryu ◽  
Miyoung Shin ◽  
Sun Ah Kim ◽  
Sangmin Lee ◽  
Hyunjoon Kim ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Fluorescence Imaging ◽  
Cancer Diagnosis ◽  
In Vivo Fluorescence ◽  
Epidermal Growth ◽  
In Vivo Fluorescence Imaging

Hybrid Antibodies in Cancer Diagnosis and Therapy

1989 ◽  
Vol 4 (3) ◽  
pp. 131-134 ◽  
Author(s):  
S. Ménard ◽  
S. Canevari ◽  
M.I. Colnaghi
Keyword(s):  
Tumor Cell ◽  
Cancer Diagnosis ◽  
Cytotoxic T Cells ◽  
Lymphocyte Activation ◽  
Cytotoxic Agents ◽  
Toxic Agent ◽  
In Vivo Models ◽  
Promising Tool

Monoclonal Antibodies (Mabs) represent a promising tool for cancer diagnosis and theraphy. Administration of MAbs alone or conjugated to cytotoxic agents has been attempted but has significant limitations. Another potentially effective approach is the use of bispecific or bifunctional antibodies where the capacity to recognize the tumor cell and the toxic agent or lymphocyte activation molecule are united in one MAb. The hybrid molecule can be produced by chemical linkage between the two parentalantibodies, or alternatively by a biological approach that consists in the fusion of the two selected hybridomas. In the resulting quadroma cell the hybridoma immunoglobulin chains recombine randomly to form the bifunctional MAb. In different in vitro and in vivo models, bifunctional MAbs against tumor and CDS at nanomolar concentration has been shown to promote tumor cell killing by cytotoxic T cells. Specific localization of chemotherapeutic drugs in xenografted tumors has been demonstrated in mice pretreated with hybrid MAbs. The advantages of the hybrid MAb approach are that it should reduce the MAb biodistribution problem and that it involves no chemical manipulation between the functional agent and the MAb molecules.

Laser for in vivo Skin Cancer Diagnosis. Reflectance Confocal Microscopy

2012 ◽  
pp. 368-375
Author(s):  
Virginia Sánchez ◽  
Jesus Cuevas ◽  
Sergio Vañó-Galván ◽  
Salvador González
Keyword(s):  
Skin Cancer ◽  
Confocal Microscopy ◽  
Cancer Diagnosis ◽  
Reflectance Confocal Microscopy

Raman Spectroscopic Analysis of Single White Blood Cell of DM Mouse in vivo

2012 ◽  
Vol 49 (6) ◽  
pp. 063001
Author(s):  
牛丽媛 Niu Liyuan ◽  
林漫漫 Lin Manman ◽  
李雪 Li Xue ◽  
董云亮 Dong Yunliang ◽  
魏坤莲 Wei Kunlian ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Spectroscopic Analysis ◽  
Raman Spectroscopic ◽  
Raman Spectroscopic Analysis

scholarly journals Noncovalent Bonds, Spectral and Thermal Properties of Substituted Thiazolo[2,3-b][1,3]thiazinium Triiodides

Crystals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 506 ◽  
Author(s):  
Irina Yushina ◽  
Natalya Tarasova ◽  
Dmitry Kim ◽  
Vladimir Sharutin ◽  
Ekaterina Bartashevich
Keyword(s):  
Electron Density ◽  
Noncovalent Interactions ◽  
Material Design ◽  
Spectroscopic Properties ◽  
Structural Features ◽  
Halogen Bonds ◽  
X Ray Diffraction ◽  
Raman Spectroscopic ◽  
Pairwise Interactions ◽  
Noncovalent Bonds

The interrelation between noncovalent bonds and physicochemical properties is in the spotlight due to the practical aspects in the field of crystalline material design. Such study requires a number of similar substances in order to reveal the effect of structural features on observed properties. For this reason, we analyzed a series of three substituted thiazolo[2,3-b][1,3]thiazinium triiodides synthesized by an iodocyclization reaction. They have been characterized with the use of X-ray diffraction, Raman spectroscopy, and thermal analysis. Various types of noncovalent interactions have been considered, and an S…I chalcogen bond type has been confirmed using the electronic criterion based on the calculated electron density and electrostatic potential. The involvement of triiodide anions in the I…I halogen and S…I chalcogen bonding is reflected in the Raman spectroscopic properties of the I–I bonds: identical bond lengths demonstrate different wave numbers of symmetric triiodide vibration and different values of electron density at bond critical points. Chalcogen and halogen bonds formed by the terminal iodine atom of triiodide anion and numerous cation…cation pairwise interactions can serve as one of the reasons for increased thermal stability and retention of iodine in the melt under heating.

Sign in / Sign up

Export Citation Format

Share Document