Tumor-Marker-Mediated “on-Demand” Drug Release and Real-Time Monitoring System Based on Multifunctional Mesoporous Silica Nanoparticles

2014 ◽  
Vol 86 (20) ◽  
pp. 10239-10245 ◽  
Author(s):  
Xiang-Ling Li ◽  
Nan Hao ◽  
Hong-Yuan Chen ◽  
Jing-Juan Xu
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Tumor Marker ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Monitoring System ◽  
Mesoporous Silica Nanoparticles ◽  
Real Time Monitoring ◽  
On Demand

Monitoring of “on-demand” drug release using dual tumor marker mediated DNA-capped versatile mesoporous silica nanoparticles

2017 ◽  
Vol 53 (62) ◽  
pp. 8755-8758 ◽  
Author(s):  
Song Wang ◽  
Fei Liu ◽  
Xiang-Ling Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Tumor Marker ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
On Demand ◽  
Controllable Release ◽  
Internal Stimulus

We constructed a versatile drug delivery system using dual internal stimulus, achieving controllable release and monitoring simultaneously.

Design of a versatile nanocomposite for ‘seeing’ drug release and action behavior

2015 ◽  
Vol 3 (43) ◽  
pp. 8449-8458 ◽  
Author(s):  
Yu Zhang ◽  
Tingting Shen ◽  
Xia Deng ◽  
Yufei Ma ◽  
Lina Wang ◽  
...  
Keyword(s):  
Rare Earth ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Mesoporous Silica Nanoparticles ◽  
Magnetic Core ◽  
New Method ◽  
Rare Earth Complex ◽  
Real Time Monitoring

To design a new method for ‘seeing’ drug release and action behavior, we combined a rare-earth complex with a magnetic-core-coated phenyl mesoporous silica nanoparticles matrix, taking advantage of the drug coordination for real-time monitoring.

Dual-responsive mesoporous silica nanoparticles coated with carbon dots and polymers for drug encapsulation and delivery

Nanomedicine ◽  
2020 ◽  
Vol 15 (25) ◽  
pp. 2447-2458
Author(s):  
Xiaona Li ◽  
Shun Hu ◽  
Zhe Lin ◽  
Jie Yi ◽  
Xue Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Fluorescence Intensity ◽  
Carbon Dots ◽  
Mesoporous Silica Nanoparticles ◽  
Aldehyde Group ◽  
Real Time Monitoring ◽  
Dual Responsive

Aim: Smart mesoporous silica nanoparticles (MSNs) coated with carbon dots (CDs) and poly(N-vinylcaprolactam) (PNVCL) as a mixed shell (CDs/PNVCL polymer grafted MSNs) were prepared for pH-trigged anticancer drug release and real-time monitoring. Materials & methods: The amino-terminated PNVCL and amino-rich CDs were grafted onto the surface of aldehyde group functionalized MSNs through Schiff base reaction. Doxorubicin (DOX) was loaded into the prepared nanoparticles. Results: DOX could be quickly released in the tumor environment, leading to cell apoptosis. The linear fit between the percentage of released DOX and the fluorescence intensity of CDs indicated that the change in fluorescence intensity could be used to monitor drug release in real time. Conclusion: The as-prepared CDs/PNVCL polymer grafted MSNs are promising candidates for integrating controllable release and real-time monitoring in cancer treatment.

Real-time imaging of intracellular drug release from mesoporous silica nanoparticles based on fluorescence resonance energy transfer

2014 ◽  
Vol 2 (27) ◽  
pp. 4379-4386 ◽  
Author(s):  
Jun Wang ◽  
Peng Pei Gao ◽  
Xiao Xi Yang ◽  
Ting Ting Wang ◽  
Jian Wang ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Fluorescence Resonance Energy Transfer ◽  
Mesoporous Silica Nanoparticles ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Fluorescence Resonance

A multifunctional nanodevice is designed based on doxorubicin (DOX)-loaded green fluorescent mesoporous silica nanoparticles (FMSN) conjugated with folic acid (FA). Real-time monitoring of intracellular drug release based on fluorescence resonance energy transfer is achieved.

Smart mesoporous silica nanoparticles gated by pillararene-modified gold nanoparticles for on-demand cargo release

2016 ◽  
Vol 52 (95) ◽  
pp. 13775-13778 ◽  
Author(s):  
Xin Wang ◽  
Li-Li Tan ◽  
Xi Li ◽  
Nan Song ◽  
Zheng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
On Demand

A new drug delivery system, based on mesoporous silica nanoparticles gated by carboxylatopillar[5]arene-modified gold nanoparticles, has been fabricated for controlled drug release.

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