Semiautomated pH Gradient Ion-Exchange Chromatography of Monoclonal Antibody Charge Variants

2014 ◽  
Vol 86 (19) ◽  
pp. 9794-9799 ◽  
Author(s):  
Mohammad Talebi ◽  
Robert A. Shellie ◽  
Emily F. Hilder ◽  
Nathan A. Lacher ◽  
Paul R. Haddad
Keyword(s):  
Monoclonal Antibody ◽  
Ion Exchange ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Ph Gradient ◽  
Charge Variants

Separation of charge variants of a monoclonal antibody by overloaded ion exchange chromatography

2021 ◽  
Vol 1658 ◽  
pp. 462607
Author(s):  
Krystian Baran ◽  
Patrycja Zimoch ◽  
Artur Stańczak ◽  
Wojciech Piątkowski ◽  
Dorota Antos
Keyword(s):  
Monoclonal Antibody ◽  
Ion Exchange ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Charge Variants

Simulation model for overloaded monoclonal antibody variants separations in ion-exchange chromatography

2012 ◽  
Vol 1253 ◽  
pp. 32-43 ◽  
Author(s):  
Bertrand Guélat ◽  
Guido Ströhlein ◽  
Marco Lattuada ◽  
Lydia Delegrange ◽  
Pascal Valax ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Ion Exchange ◽  
Simulation Model ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography

Selection of pH-related parameters in ion-exchange chromatography using pH-gradient operations

2008 ◽  
Vol 1194 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Tangir Ahamed ◽  
Sreekanth Chilamkurthi ◽  
Beckley K. Nfor ◽  
Peter D.E.M. Verhaert ◽  
Gijs W.K. van Dedem ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Ph Gradient ◽  
Selection Of

Mixed-Bed Ion Exchange Chromatography Employing a Salt-Free pH Gradient for Improved Sensitivity and Compatibility in MudPIT

2013 ◽  
Vol 85 (14) ◽  
pp. 6608-6616 ◽  
Author(s):  
Geert P. M. Mommen ◽  
Hugo D. Meiring ◽  
Albert J. R. Heck ◽  
Ad P. J. M. de Jong
Keyword(s):  
Ion Exchange ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Ph Gradient ◽  
Mixed Bed Ion Exchange

Model-based prediction of monoclonal antibody retention in ion-exchange chromatography

2013 ◽  
Vol 1298 ◽  
pp. 17-25 ◽  
Author(s):  
Bertrand Guélat ◽  
Lydia Delegrange ◽  
Pascal Valax ◽  
Massimo Morbidelli
Keyword(s):  
Monoclonal Antibody ◽  
Ion Exchange ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Model Based

pH-gradient ion-exchange chromatography: An analytical tool for design and optimization of protein separations

2007 ◽  
Vol 1164 (1-2) ◽  
pp. 181-188 ◽  
Author(s):  
Tangir Ahamed ◽  
Beckley K. Nfor ◽  
Peter D.E.M. Verhaert ◽  
Gijs W.K. van Dedem ◽  
Luuk A.M. van der Wielen ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Analytical Tool ◽  
Ph Gradient ◽  
Protein Separations ◽  
Design And Optimization
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