scholarly journals In-Depth Method for the Characterization of Glycosylation in Manufactured Recombinant Monoclonal Antibody Drugs

2014 ◽  
Vol 86 (12) ◽  
pp. 5661-5666 ◽  
Author(s):  
Ting Song ◽  
Sureyya Ozcan ◽  
Alicia Becker ◽  
Carlito B. Lebrilla
Keyword(s):  
Monoclonal Antibody ◽  
Recombinant Monoclonal Antibody

Characterization of a recombinant monoclonal antibody by mass spectrometry combined with liquid chromatography

2001 ◽  
Vol 752 (2) ◽  
pp. 247-261 ◽  
Author(s):  
Lobvi E.Matamoros Fernández ◽  
Dário E. Kalume ◽  
Loany Calvo ◽  
Minerva Fernández Mallo ◽  
Antonio Vallin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Liquid Chromatography ◽  
Recombinant Monoclonal Antibody

scholarly journals Characterization of a Type-Common Human Recombinant Monoclonal Antibody to Herpes Simplex Virus with High Therapeutic Potential

1998 ◽  
Vol 36 (11) ◽  
pp. 3198-3204 ◽  
Author(s):  
Alessandro De Logu ◽  
R. Anthony Williamson ◽  
Roman Rozenshteyn ◽  
Fernando Ramiro-Ibañez ◽  
Cindy D. Simpson ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Therapeutic Potential ◽  
Recombinant Antibody ◽  
Antigenic Site ◽  
Recombinant Monoclonal Antibody ◽  
Simplex Virus

We report the characterization of a type-common human recombinant monoclonal antibody previously isolated by antigen selection from a phage-displayed combinatorial antibody library established from a herpes simplex virus (HSV)-seropositive individual. Competition with well-characterized murine monoclonal antibodies and immunodetection of gD truncations revealed that this antibody recognizes the group Ib antigenic site of glycoprotein D, a highly conserved and protective type-common determinant. To our knowledge, this is the first human group Ib monoclonal antibody ever described. The antibody also displayed first-order neutralization kinetics and a high neutralization rate constant, was capable of completely inhibiting syncytium formation by a fusogenic strain of HSV type 1, and efficiently neutralized low-passage clinical isolates of both HSV serotypes. Taken together with our earlier observations of the in vivo antiviral activities of this human recombinant antibody in animal models of HSV infection, the present results support the high therapeutic potential of this antibody.

Analytical artifacts in characterization of recombinant monoclonal antibody therapeutics

2020 ◽  
Vol 183 ◽  
pp. 113131
Author(s):  
Dongdong Wang ◽  
Christine Nowak ◽  
Bruce Mason ◽  
Amit Katiyar ◽  
Hongcheng Liu
Keyword(s):  
Monoclonal Antibody ◽  
Recombinant Monoclonal Antibody ◽  
Antibody Therapeutics

Characterization of recombinant monoclonal antibody charge variants using WCX chromatography, icIEF and LC-MS/MS

2019 ◽  
Vol 564-565 ◽  
pp. 1-12 ◽  
Author(s):  
Hailong Liu ◽  
Weicheng Ren ◽  
Li Zong ◽  
Jinliang Zhang ◽  
Yingwu Wang
Keyword(s):  
Monoclonal Antibody ◽  
Recombinant Monoclonal Antibody ◽  
Charge Variants

scholarly journals Characterization of a Synovial B Cell–Derived Recombinant Monoclonal Antibody Targeting Stromal Calreticulin in the Rheumatoid Joints

2018 ◽  
Vol 201 (5) ◽  
pp. 1373-1381 ◽  
Author(s):  
Elisa Corsiero ◽  
Lucas Jagemann ◽  
Mauro Perretti ◽  
Costantino Pitzalis ◽  
Michele Bombardieri
Keyword(s):  
Monoclonal Antibody ◽  
B Cell ◽  
Recombinant Monoclonal Antibody ◽  
Antibody Targeting
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