Determination of sulfadimethoxine in the liver and kidneys of swine and cattle by gas chromatography-chemical ionization mass spectrometry and stable isotope dilution

1980 ◽  
Vol 52 (6) ◽  
pp. 842-846 ◽  
Author(s):  
William. Garland ◽  
Barbara. Miwa ◽  
George. Weiss ◽  
Gloria. Chen ◽  
Robert. Saperstein ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Stable Isotope ◽  
Isotope Dilution ◽  
Chemical Ionization ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Stable Isotope Dilution

Measurement of sodium valproate in serum by direct-insertion chemical-ionization/mass spectrometry.

1980 ◽  
Vol 26 (1) ◽  
pp. 147-149
Author(s):  
G M Schier ◽  
I E Gan ◽  
B Halpern ◽  
J Korth
Keyword(s):  
Mass Spectrometry ◽  
Stable Isotope ◽  
Sodium Valproate ◽  
Chromatographic Separation ◽  
Chemical Ionization ◽  
Internal Standard ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass

Abstract To quantitatively determine sodium valproate, we use a stable isotope-labeled internal standard and chemical-ionization/mass spectrometry, without prior chromatographic separation. The technique is rapid, simple, sensitive, and provides for the routine analysis of 100 microL of serum with good within-day and day-to-day precision. The technique also allows for the simultaneous determination of phenobarbital, mephobarbital, carbamazepine, primidone, and phenytoin.

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