Automated simultaneous qualitative and quantitative analysis of complex organic mixtures with a gas chromatography-mass spectrometry-computer system

1978 ◽  
Vol 50 (3) ◽  
pp. 433-441 ◽  
Author(s):  
S. C. Gates ◽  
M. J. Smisko ◽  
C. L. Ashendel ◽  
N. D. Young ◽  
J. F. Holland ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Quantitative Analysis ◽  
Computer System ◽  
Gas Chromatography Mass Spectrometry ◽  
Qualitative And Quantitative Analysis ◽  
Organic Mixtures ◽  
Qualitative And Quantitative ◽  
Chromatography Mass Spectrometry ◽  
Complex Organic

scholarly journals Quantitative Analysis by Gas Chromatography / Mass Spectrometry of Heroin Traded in Kuwait during 2016 – 2017, and Its Comparison with Results of Analyzing Heroin Traded during 2012 and Addicts Death Rate Statistics during 2011 – 2018

2020 ◽  
pp. 12-22
Author(s):  
N. A. Al-Abkal ◽  
E. Kh. Metwally ◽  
S. R. Alezzbawy ◽  
Kh. Y. Orabi ◽  
Sh. H. Alshammari
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Quantitative Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Qualitative And Quantitative Analysis ◽  
Satisfactory Explanation ◽  
Heroin Addicts ◽  
Qualitative And Quantitative ◽  
Chromatography Mass Spectrometry ◽  
Quantitative Analyses

Aim: To compare the main and additive components of heroin trafficked in the Stateof Kuwait during 2012 with those components of heroin traded recently in the country during 2016 and 2017, and to provide a satisfactory explanation for the increase in deaths among heroin addicts during the period2011 -2018. Study Design: Selected samples of non-pure powder heroin seized in Kuwait during 2016 and 2017, with pure heroin and a set of10 pure different heroin component standards, all have been quantitatively analyzed in the Forensic Laboratories. Place and Duration of Study: All qualitative and quantitative analyses for 2016 and 2017 samples were conducted in the Forensic Laboratories of the General Department of Criminal Evidences – Ministry of Interior – State of Kuwait. Methodology: By using Gas Chromatography/Mass Spectrometry (GC/MS) to qualitative and quantitative analysis have been made on a total of hundred samples of non-pure powder heroin seized in Kuwait during the years 2016 and 2017, in addition to ten pure standards. Results: The concentration of the diacetylmorphine (active substance of heroin) in Kuwait during the year 2017 are much higher than the concentration during the year 2016. The additive substances (adulterants) for the years 2016 and 2017, are shared with the year 2012 by the component's paracetamol, caffeine and diazepam with different concentrations. But new adulterants in recent years are recorded in samples 2016 and 2017, including methamphetamine, dextromethorphan, and methylphenidate which is absent in 2016 samples. Conclusion: The concentration % of illicit heroin traded in Kuwait as diacetylmorphine has increase from 10% to 50% for year 2016, and further from 30% - 70% for year 2017, which marks identified a substantial rising in the purity of heroin. In addition, additive substances in the two years include paracetamol (acetaminophen), caffeine and diazepam, previously recorded in 2012. However, totally different new adulterates are recorded in 2016 and 2017 samples, including methamphetamine, dextromethorphan, and methylphenidate. All new three adulterates are detected in quite a few numbers of samples with methylphenidate recorded in a very low concentration of 0. 01 mg. Both new adulterates and higher purity of heroin constitute the main reasons for rising the rate of deaths between heroin addicts in recent years. Also, recent UN reports (12,18) provide evidence that the GC countries Afghanistan, Iran and Pakistan are still manufacturing and trading the above mentioned new adulterates.

Comprehensive Analysis of Volatile Compounds in Mouthpiece Cigarette Adhesive by Coupling Headspace with Gas Chromatography-Mass Spectrometry

2020 ◽  
Author(s):  
Min Wei ◽  
Feng Zheng ◽  
Xuyan Song ◽  
Ran Li ◽  
Xi Pan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Quantitative Analysis ◽  
Volatile Compounds ◽  
Analytical Method ◽  
Gas Chromatography Mass Spectrometry ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Chromatography Mass Spectrometry ◽  
Relative Standard

Abstract Background Some volatile compounds in mouthpiece cigarette adhesive emit irritating odors and affect the taste of smoking cigarettes. Therefore, it is necessary to monitor the volatile compounds in mouthpiece cigarette adhesive. Objectives A rapid and simple analytical method of volatile compounds in mouthpiece cigarette adhesive was established. Methods In this study, headspace (HS) injection coupled with gas chromatography-mass spectrometry (GC-MS) was utilized for qualitative and quantitative analysis. Initially, the volatile compounds in mouthpiece cigarette adhesives were detected by HS-GC-MS, followed by spectrum library retrieval. The detected compounds with the similarity to spectrum library of more than 85% were further identified by comparing the retention time and mass spectra of the detected volatile compounds and those of the corresponding standard samples. The quantitative analysis of 9 identified volatile compounds was performed. Results Eleven volatile compounds in the mouthpiece cigarette adhesive were accurately identified. The quantitative analytical method of 9 volatile compounds in mouthpiece cigarette adhesive was validated to have good linearities (R2 > 0.9932) within the range of 20–5000 ng/g. The detection limits of 9 compounds were within the range of 3.1–147.7 ng/g. The intra- and inter-day relative standard deviations (RSDs) were less than 19.8%. The recoveries of these 9 compounds spiked into mouthpiece cigarette adhesive were from 68.1% to 108.3%. Conclusions The proposed method is rapid, simple, and accurate for qualitative and quantitative analysis of volatile compounds in the mouthpiece cigarette adhesive. Highlights The developed analytical method is expected to be used to monitor volatile compounds in various adhesives.

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