Electrochemical Detection of Human Cytochrome P450 2A6 Inhibition: A Step toward Reducing Dependence on Smoking

Silvia Castrignanò; Alex Ortolani; Sheila J. Sadeghi; Giovanna Di Nardo; Paola Allegra; Gianfranco Gilardi

doi:10.1021/ac4041839

Electrochemical Detection of Human Cytochrome P450 2A6 Inhibition: A Step toward Reducing Dependence on Smoking

Analytical Chemistry ◽

10.1021/ac4041839 ◽

2014 ◽

Vol 86 (5) ◽

pp. 2760-2766 ◽

Cited By ~ 12

Author(s):

Silvia Castrignanò ◽

Alex Ortolani ◽

Sheila J. Sadeghi ◽

Giovanna Di Nardo ◽

Paola Allegra ◽

...

Keyword(s):

Cytochrome P450 ◽

Electrochemical Detection ◽

Human Cytochrome ◽

Cytochrome P450 2A6

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Metabolism of bilirubin by human cytochrome P450 2A6

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2012.03.010 ◽

2012 ◽

Vol 261 (1) ◽

pp. 50-58 ◽

Cited By ~ 29

Author(s):

A'edah Abu-Bakar ◽

Dionne M. Arthur ◽

Anna S. Wikman ◽

Minna Rahnasto ◽

Risto O. Juvonen ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Cytochrome ◽

Cytochrome P450 2A6 ◽

Metabolism Of Bilirubin

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Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids

Forensic Toxicology ◽

10.1007/s11419-011-0112-7 ◽

2011 ◽

Vol 29 (2) ◽

pp. 117-124 ◽

Cited By ~ 23

Author(s):

Satoshi Yamaori ◽

Chikako Maeda ◽

Ikuo Yamamoto ◽

Kazuhito Watanabe

Keyword(s):

Cytochrome P450 ◽

Differential Inhibition ◽

Human Cytochrome ◽

Cytochrome P450 2A6

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Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Carcinogenesis ◽

10.1093/carcin/14.7.1421 ◽

1993 ◽

Vol 14 (7) ◽

pp. 1421-1427 ◽

Cited By ~ 26

Author(s):

Howard F. Tiano ◽

Masakiyo Hosokawa ◽

Patricia C. Chulada ◽

P.Blaise Smith ◽

Ren-Li Wang ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Cytochrome ◽

Cytochrome P450 2A6

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Exploring coumarin egress channels in human cytochrome p450 2a6 by random acceleration and steered molecular dynamics simulations

Proteins Structure Function and Bioinformatics ◽

10.1002/prot.22880 ◽

2010 ◽

Vol 79 (1) ◽

pp. 271-281 ◽

Cited By ~ 62

Author(s):

Weihua Li ◽

Jie Shen ◽

Guixia Liu ◽

Yun Tang ◽

Tyuji Hoshino

Keyword(s):

Molecular Dynamics ◽

Cytochrome P450 ◽

Molecular Dynamics Simulations ◽

Steered Molecular Dynamics ◽

Human Cytochrome ◽

Cytochrome P450 2A6 ◽

Random Acceleration ◽

Dynamics Simulations

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The prenylated phenolic natural product isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2017.08.035 ◽

2017 ◽

Vol 109 ◽

pp. 472-479

Author(s):

Qi Wang ◽

Yi Kuang ◽

Junbin He ◽

Kai Li ◽

Wei Song ◽

...

Keyword(s):

Cytochrome P450 ◽

Natural Product ◽

Human Cytochrome ◽

Cytochrome P450 2A6

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Functional Characterization of Allelic Variants of Polymorphic Human Cytochrome P450 2A6 (CYP2A65, 7, 8, 18, 19, and 35)

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.35.394 ◽

2012 ◽

Vol 35 (3) ◽

pp. 394-399 ◽

Cited By ~ 20

Author(s):

Songhee Han ◽

Seunghye Choi ◽

Young-Jin Chun ◽

Chul-Ho Yun ◽

Chang Hoon Lee ◽

...

Keyword(s):

Cytochrome P450 ◽

Functional Characterization ◽

Allelic Variants ◽

Human Cytochrome ◽

Cytochrome P450 2A6

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A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3 -pyridyl)thiazolidin-4-one hydrochloride (SM-12502)

Pharmacogenetics ◽

10.1097/00008571-199806000-00006 ◽

1998 ◽

Vol 8 (3) ◽

pp. 239-250 ◽

Cited By ~ 83

Author(s):

Ken-ichi Nunoya ◽

Tsuyoshi Yokoi ◽

Kanzo Kimura ◽

Kazuaki Inoue ◽

Takao Kodama ◽

...

Keyword(s):

Cytochrome P450 ◽

Metabolic Capacity ◽

Human Cytochrome ◽

Cytochrome P450 2A6 ◽

Cyp2a6 Gene

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Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2007.04.028 ◽

2007 ◽

Vol 464 (2) ◽

pp. 197-206 ◽

Cited By ~ 35

Author(s):

Stefaan Sansen ◽

Mei-Hui Hsu ◽

C. David Stout ◽

Eric F. Johnson

Keyword(s):

Cytochrome P450 ◽

Substrate Specificity ◽

Human Cytochrome ◽

Cytochrome P450 2A6 ◽

Structural Insight ◽

Insight Into

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Development of a New Predictive Model for Interactions with Human Cytochrome P450 2A6 Using Pharmacophore Ensemble/Support Vector Machine (PhE/SVM) Approach

Pharmaceutical Research ◽

10.1007/s11095-008-9807-9 ◽

2008 ◽

Vol 26 (4) ◽

pp. 987-1000 ◽

Cited By ~ 23

Author(s):

Max K. Leong ◽

Yen-Ming Chen ◽

Hong-Bin Chen ◽

Po-Hong Chen

Keyword(s):

Support Vector Machine ◽

Cytochrome P450 ◽

Predictive Model ◽

Support Vector ◽

Human Cytochrome ◽

Cytochrome P450 2A6

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Kinetic Analysis of Oxidation of Coumarins by Human Cytochrome P450 2A6

Journal of Biological Chemistry ◽

10.1074/jbc.m411019200 ◽

2005 ◽

Vol 280 (13) ◽

pp. 12279-12291 ◽

Cited By ~ 73

Author(s):

Chul-Ho Yun ◽

Keon-Hee Kim ◽

M. Wade Calcutt ◽

F. Peter Guengerich

Keyword(s):

Cytochrome P450 ◽

Kinetic Analysis ◽

Human Cytochrome ◽

Cytochrome P450 2A6

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Electrochemical Detection of Human Cytochrome P450 2A6 Inhibition: A Step toward Reducing Dependence on Smoking

Metabolism of bilirubin by human cytochrome P450 2A6

Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids

Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Exploring coumarin egress channels in human cytochrome p450 2a6 by random acceleration and steered molecular dynamics simulations

The prenylated phenolic natural product isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6

Functional Characterization of Allelic Variants of Polymorphic Human Cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35)

A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3 -pyridyl)thiazolidin-4-one hydrochloride (SM-12502)

Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants

Development of a New Predictive Model for Interactions with Human Cytochrome P450 2A6 Using Pharmacophore Ensemble/Support Vector Machine (PhE/SVM) Approach

Kinetic Analysis of Oxidation of Coumarins by Human Cytochrome P450 2A6

Functional Characterization of Allelic Variants of Polymorphic Human Cytochrome P450 2A6 (CYP2A65, 7, 8, 18, 19, and 35)