scholarly journals Highly Stable Surface Functionalization of Microgas Chromatography Columns Using Layer-by-Layer Self-Assembly of Silica Nanoparticles

2013 ◽  
Vol 85 (17) ◽  
pp. 8135-8141 ◽  
Author(s):  
Dong Wang ◽  
Hamza Shakeel ◽  
John Lovette ◽  
Gary W. Rice ◽  
James R. Heflin ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Surface Functionalization ◽  
Self Assembly ◽  
Layer By Layer ◽  
Stable Surface ◽  
Chromatography Columns

Preparation of Very Reactive Thiol-Protected Gold Nanoparticles: Revisiting the Brust-Schiffrin Method

2006 ◽  
Vol 6 (3) ◽  
pp. 708-712 ◽  
Author(s):  
Koiti Araki ◽  
Eisuke Mizuguchi ◽  
Hirofumi Tanaka ◽  
Takuji Ogawa
Keyword(s):  
Thin Films ◽  
Gold Nanoparticles ◽  
Surface Functionalization ◽  
Self Assembly ◽  
Gold Clusters ◽  
Layer By Layer ◽  
Inorganic Hybrid ◽  
New Material ◽  
Modified Surface ◽  
Layer Control

The preparation and properties of tert-dodecanethiol protected gold nanoparticles amenable to very rapid surface functionalization by associative mechanism is described. The new material can be easily prepared by controlling the reaction time, because only a limited but enough number of tert-dodecanethiol to stabilize the gold clusters is bond to the surface until about an hour. Accordingly, it can be isolated as a solid and handled much like the highly stabilized Brust-Schiffrin analogues, but reacted very rapidly with any molecular species containing one or multiple functional groups such as thiol, disulfide, pyridine, etc., These characteristics are ideal for the preparation of a variety of new organic–inorganic hybrid nanomaterials by coordinative self-assembly. This possibility was illustrated using meso-tetra(4-pyridyl)porphyrin, which promptly bonded to the reactive protected gold nanoparticles generating a solid that can be grown as thin films with layer-by-layer control on a suitably modified surface.

Cell labeling efficiency of layer-by-layer self-assembly modified silica nanoparticles

2009 ◽  
Vol 24 (4) ◽  
pp. 1317-1321 ◽  
Author(s):  
Gang Liu ◽  
Jing Tian ◽  
Chen Liu ◽  
Hua Ai ◽  
Zhongwei Gu ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Self Assembly ◽  
Laser Scanning ◽  
Control Cell ◽  
Silica Nanoparticle ◽  
Laser Scanning Microscopy ◽  
Cell Labeling ◽  
Cell Uptake ◽  
Confocal Laser ◽  
Layer By Layer

In the present study, we compared cytotoxicity and cell uptake of silica nanoparticles with four different surface coatings generated through layer-by-layer self-assembly. Rabbit mesenchymal stem cells (rMSCs) were labeled with silica nanoparticles of different coatings including poly(ethyleneimine) (PEI), poly(allylamine hydrochloride) (PAH), poly(anetholesulfonic acid, sodium salt) (PAS), and dextran sulfate. The MTT [3-(4, 5-dimethylthiazol-2)-2, 5-diphenyl-2H-tetrazolium bromide] test was performed to quantify the cell biocompatibility. The cellular uptake of those silica nanoparticles was determined by flow cytometry and confocal laser scanning microscopy. The results showed that all examined silica nanoparticles were stable in aqueous phase with high monodispersity. Labeled rMSCs are unaffected in their viability, apoptosis, and differentiation capacities. The silica nanoparticle-coated synthetic polycations such as PEI or PAH have higher cell internalization than negatively charged polyelectrolytes. The ability to control cell uptake of different particles may have applications in cell labeling, cell separation, and other biomedical applications.

Optical thin film filters of colloidal gold and silica nanoparticles prepared by a layer-by-layer self-assembly method

2011 ◽  
Vol 46 (21) ◽  
pp. 6877-6882 ◽  
Author(s):  
Zaheer Abbas Khan ◽  
Rachana Kumar ◽  
Waleed S. Mohammed ◽  
Gabor L. Hornyak ◽  
Joydeep Dutta
Keyword(s):  
Thin Film ◽  
Silica Nanoparticles ◽  
Self Assembly ◽  
Colloidal Gold ◽  
Layer By Layer ◽  
Optical Thin Film ◽  
Assembly Method ◽  
Thin Film Filters

Superhydrophobic hybrid films prepared from silica nanoparticles and ionic liquids via layer-by-layer self-assembly

2014 ◽  
Vol 570 ◽  
pp. 27-32 ◽  
Author(s):  
Chenyun Zhang ◽  
Shengnan Zhang ◽  
Picheng Gao ◽  
Hongmin Ma ◽  
Qin Wei
Keyword(s):  
Ionic Liquids ◽  
Silica Nanoparticles ◽  
Self Assembly ◽  
Layer By Layer ◽  
Hybrid Films

Preparation of multi-shell structured fluorescent composite nanoparticles for ultrasensitive human procalcitonin detection

RSC Advances ◽  
2015 ◽  
Vol 5 (8) ◽  
pp. 5988-5995 ◽  
Author(s):  
Yue Zhao ◽  
Changhua Zhou ◽  
Ruili Wu ◽  
Lin Li ◽  
Huaibin Shen ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Silica Nanoparticles ◽  
Self Assembly ◽  
Composite Nanoparticles ◽  
Layer By Layer ◽  
Protection Method ◽  
Assembly Technique

In this paper, we reported the preparation of carboxyl functionalized quantum dots (QDs)-embedded silica nanoparticles by combining layer-by-layer (LbL) self-assembly technique and a multi-layer protection method.

scholarly journals Cylindrical Microparticles Composed of Mesoporous Silica Nanoparticles for the Targeted Delivery of a Small Molecule and a Macromolecular Drug to the Lungs: Exemplified with Curcumin and siRNA

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 844
Author(s):  
Thorben Fischer ◽  
Inga Winter ◽  
Robert Drumm ◽  
Marc Schneider
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Alveolar Epithelial Cells ◽  
In Vitro Toxicity ◽  
Layer By Layer ◽  
Necrosis Factor Alpha ◽  
Aerodynamic Properties ◽  
Tnf Α

The transport of macromolecular drugs such as oligonucleotides into the lungs has become increasingly relevant in recent years due to their high potency. However, the chemical structure of this group of drugs poses a hurdle to their delivery, caused by the negative charge, membrane impermeability and instability. For example, siRNA to reduce tumour necrosis factor alpha (TNF-α) secretion to reduce inflammatory signals has been successfully delivered by inhalation. In order to increase the effect of the treatment, a co-transport of another anti-inflammatory ingredient was applied. Combining curcumin-loaded mesoporous silica nanoparticles in nanostructured cylindrical microparticles stabilized by the layer-by-layer technique using polyanionic siRNA against TNF-α was used for demonstration. This system showed aerodynamic properties suited for lung deposition (mass median aerodynamic diameter of 2.85 ± 0.44 µm). Furthermore, these inhalable carriers showed no acute in vitro toxicity tested in both alveolar epithelial cells and macrophages up to 48 h incubation. Ultimately, TNF-α release was significantly reduced by the particles, showing an improved activity co-delivering both drugs using such a drug-delivery system for specific inhibition of TNF-α in the lungs.

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