Determination of Types and Binding Sites of Advanced Glycation End Products for Substance P

2012 ◽  
Vol 84 (24) ◽  
pp. 10568-10575 ◽  
Author(s):  
Andrea F. Lopez-Clavijo ◽  
Mark P. Barrow ◽  
Naila Rabbani ◽  
Paul J. Thornalley ◽  
Peter B. O’Connor
Keyword(s):  
Substance P ◽  
Advanced Glycation End Products ◽  
Binding Sites ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Development of a method for the determination of advanced glycation end products precursors by liquid chromatography and its application in human urine samples

2012 ◽  
Vol 35 (19) ◽  
pp. 2575-2584 ◽  
Author(s):  
María del Carmen Hurtado-Sánchez ◽  
Anunciación Espinosa-Mansilla ◽  
María Isabel Rodríguez-Cáceres ◽  
Elisabet Martín-Tornero ◽  
Isabel Durán-Merás
Keyword(s):  
Liquid Chromatography ◽  
Advanced Glycation End Products ◽  
Human Urine ◽  
Urine Samples ◽  
Advanced Glycation ◽  
Human Urine Samples ◽  
Glycation End Products ◽  
End Products

Abstract 5292: Determination of the receptor for advanced glycation end-products in breast cancer patients previous chemotherapy

2015 ◽  
Author(s):  
Jorge A. Guadarrama-Orozco ◽  
Erika B. Ruiz-García ◽  
Hector A. Maldonado-Martinez ◽  
Lilia P. Barron-Rodríguez ◽  
Fernando Mainero-Ratchelous ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Advanced Glycation End Products ◽  
Breast Cancer Patients ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Evaluation of the AGE/sRAGE Axis in Patients with Multiple Myeloma

Antioxidants ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 55 ◽  
Author(s):  
Alessandro Allegra ◽  
Caterina Musolino ◽  
Elisabetta Pace ◽  
Vanessa Innao ◽  
Eleonora Di Salvo ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Advanced Glycation End Products ◽  
Healthy Subjects ◽  
Advanced Glycation ◽  
Blood Samples ◽  
Significant Difference ◽  
Glycation End Products ◽  
End Products ◽  
Stress Influences

Glycative stress influences tumor progression. The aim of the present study was to evaluate the advanced glycation end products/soluble receptor of advanced glycation end products (AGE/sRAGE) axis in patients with multiple myeloma (MM). Blood samples were taken from 19 patients affected by MM and from 16 sex-matched and age-matched healthy subjects. AGE and sRAGE axis were dosed in patients with MM and matched with controls. AGEs were measured by spectrofluorimetric methods. Blood samples for the determination of sRAGE were analyzed by ELISA. AGE levels were significantly reduced in patients with respect to controls. Instead, sRAGE was significantly elevated in patients affected by MM compared to healthy subjects. Moreover, we showed that there was a statistically significant difference in sRAGE according to the heavy and light chain. IgA lambda had significantly higher sRAGE values than IgA kappa, IgG kappa, and IgG Lambda MM patients. From our data emerges the role of the sRAGE/AGE axis in MM. Since AGE is a positive regulator of the activity of RAGE, circulating sRAGE concentrations may reflect RAGE expression and may be raised in parallel with serum AGE concentrations as a counter-system against AGE-caused tissue damage. Serum concentrations of AGE and sRAGE could therefore become potential therapeutic targets.

scholarly journals Inhibitory Effect of Several Mangifera indica Cultivar Leaf Extracts on the Formation of Advanced Glycation End Products (AGEs)

2020 ◽  
Vol 9 (2) ◽  
pp. 33
Author(s):  
Kimihisa Itoh ◽  
Tetsuya Matsukawa ◽  
Kanasa Minami ◽  
Mamoru Okamoto ◽  
Norimichi Tomohiro ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Inhibitory Activity ◽  
Mangifera Indica ◽  
Inhibitory Effect ◽  
Advanced Glycation ◽  
Leaf Extracts ◽  
Glycation End Products ◽  
End Products ◽  
Indica Cultivar

As a part of our ongoing research to find novel functions in mango leaves, we have reported that the methanolic extract of pruned old dark green mango leaf (Mangifera indica ‘Irwin’) exhibited inhibitory effects on the formation of advanced glycation end products (AGEs) in nonenzymatic glycation of albumin. The purpose of this study was to find other mango cultivars with more potent activity in this regard. We examined the inhibitory effect of seventeen mango (Mangifera indica) cultivar leaf extracts on AGEs formation. We also investigated the relationship between the inhibitory activity of the extracts and the contents of their active components, 3-C-β-D-glucosyl-2,4,4’,6-tetrahydroxybenzophenone (1), mangiferin (2) and chlorophyll (3). On the basis of the evaluation of the inhibitory activity of mango cultivar leaf extracts, the HPLC determination of the contents of 1 and 2, and the spectrophotometric determination of 3, it was found that almost all extract showed a significant activity, and the content of 2 and 3 detected in each was similar. In contrast, AGEs formation inhibition tended to be higher as the content of 1 in the leaf extracts increased. This is the first report of phytochemical analysis of compounds 1, 2 and 3 in various cultivars of mango leaf. From the phytochemical point of view, these results suggest that the pruned leaves of any cultivar of Mangifera indica except ‘Chiin Hwang No. 1’ and ‘Kyo Savoy’ may be useful for the preparation of natural ingredients with inhibitory activity of AGEs formation.

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