Direct Plasma Metabolite Analysis of Positron Emission Tomography Radioligands by Micellar Liquid Chromatography with Radiometric Detection

Ryuji Nakao; Magnus Schou; Christer Halldin

doi:10.1021/ac2032657

Direct Plasma Metabolite Analysis of Positron Emission Tomography Radioligands by Micellar Liquid Chromatography with Radiometric Detection

Analytical Chemistry ◽

10.1021/ac2032657 ◽

2012 ◽

Vol 84 (7) ◽

pp. 3222-3230 ◽

Cited By ~ 24

Author(s):

Ryuji Nakao ◽

Magnus Schou ◽

Christer Halldin

Keyword(s):

Positron Emission Tomography ◽

Liquid Chromatography ◽

Micellar Liquid Chromatography ◽

Emission Tomography ◽

Metabolite Analysis ◽

Positron Emission ◽

Radiometric Detection ◽

Plasma Metabolite

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Rapid metabolite analysis of positron emission tomography radioligands by direct plasma injection combining micellar cleanup with high submicellar liquid chromatography with radiometric detection

Journal of Chromatography A ◽

10.1016/j.chroma.2012.10.022 ◽

2012 ◽

Vol 1266 ◽

pp. 76-83 ◽

Cited By ~ 11

Author(s):

Ryuji Nakao ◽

Magnus Schou ◽

Christer Halldin

Keyword(s):

Positron Emission Tomography ◽

Liquid Chromatography ◽

Emission Tomography ◽

Metabolite Analysis ◽

Plasma Injection ◽

Positron Emission ◽

Radiometric Detection

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“Mixed” anionic and non-ionic micellar liquid chromatography for high-speed radiometabolite analysis of positron emission tomography radioligands

Journal of Chromatography A ◽

10.1016/j.chroma.2013.01.071 ◽

2013 ◽

Vol 1281 ◽

pp. 54-59 ◽

Cited By ~ 12

Author(s):

Ryuji Nakao ◽

Christer Halldin

Keyword(s):

Positron Emission Tomography ◽

Liquid Chromatography ◽

High Speed ◽

Micellar Liquid Chromatography ◽

Emission Tomography ◽

Positron Emission

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Simultaneous Determination of Protein-Free and Total Positron Emission Tomography Radioligand Concentrations in Plasma Using High-Performance Frontal Analysis Followed by Mixed Micellar Liquid Chromatography: Application to [11C]PBR28 in Human Plasma

Analytical Chemistry ◽

10.1021/ac401742v ◽

2013 ◽

Vol 85 (18) ◽

pp. 8728-8734 ◽

Cited By ~ 5

Author(s):

Ryuji Nakao ◽

Nahid Amini ◽

Christer Halldin

Keyword(s):

Positron Emission Tomography ◽

Liquid Chromatography ◽

Simultaneous Determination ◽

Human Plasma ◽

High Performance ◽

Micellar Liquid Chromatography ◽

Emission Tomography ◽

Frontal Analysis ◽

Positron Emission

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Combining high-performance liquid chromatography-positron detection and on-line microdialysis for animal metabolism study of positron emission tomography probes

Journal of Chromatography A ◽

10.1016/j.chroma.2008.07.049 ◽

2008 ◽

Vol 1203 (2) ◽

pp. 193-197 ◽

Cited By ~ 10

Author(s):

Ryuji Nakao ◽

Maki Okada ◽

Osamu Inoue ◽

Toshimitsu Fukumura ◽

Kazutoshi Suzuki

Keyword(s):

Positron Emission Tomography ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Performance ◽

Emission Tomography ◽

Positron Emission ◽

On Line ◽

Metabolism Study ◽

Animal Metabolism

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Determination of 5-hydroxy-l-[β-11C]tryptophan and its in vivo-formed radiolabeled metabolites in brain tissue using high performance liquid chromatography: A study supporting radiotracer kinetics obtained with positron emission tomography

Nuclear Medicine and Biology ◽

10.1016/s0969-8051(97)00114-5 ◽

1997 ◽

Vol 24 (8) ◽

pp. 733-738 ◽

Cited By ~ 14

Author(s):

Karl-Johan Lindner ◽

Per Hartvig ◽

Peter Bjurling ◽

Karl-Johan Fasth ◽

Göran Westerberg ◽

...

Keyword(s):

Positron Emission Tomography ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Brain Tissue ◽

High Performance ◽

Emission Tomography ◽

Positron Emission

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Metabolite analysis in positron emission tomography studies: examples from food sciences

Amino Acids ◽

10.1007/s00726-005-0202-0 ◽

2005 ◽

Vol 29 (4) ◽

pp. 377-388 ◽

Cited By ~ 16

Author(s):

B. Pawelke

Keyword(s):

Positron Emission Tomography ◽

Emission Tomography ◽

Metabolite Analysis ◽

Positron Emission

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Combination of positron emission tomography with liquid chromatography in neuropharmacologic research

Journal of Chromatography A ◽

10.1016/s0021-9673(01)84207-2 ◽

1990 ◽

Vol 507 ◽

pp. 303-310 ◽

Cited By ~ 2

Author(s):

Per Hartvig ◽

Bengt Långström

Keyword(s):

Positron Emission Tomography ◽

Liquid Chromatography ◽

Emission Tomography ◽

Positron Emission

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Improved radiometabolite analysis procedure for positron emission tomography (PET) radioligands using a monolithic column coupled with direct injection micellar/high submicellar liquid chromatography

Talanta ◽

10.1016/j.talanta.2013.03.024 ◽

2013 ◽

Vol 113 ◽

pp. 130-134 ◽

Cited By ~ 8

Author(s):

Ryuji Nakao ◽

Christer Halldin

Keyword(s):

Positron Emission Tomography ◽

Liquid Chromatography ◽

Monolithic Column ◽

Direct Injection ◽

Analysis Procedure ◽

Emission Tomography ◽

Positron Emission

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Sensitive determination of specific radioactivity of positron emission tomography radiopharmaceuticals by radio high-performance liquid chromatography with fluorescence detection

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2008.06.005 ◽

2008 ◽

Vol 35 (7) ◽

pp. 733-740 ◽

Cited By ~ 5

Author(s):

Ryuji Nakao ◽

Kenji Furutsuka ◽

Masatoshi Yamaguchi ◽

Kazutoshi Suzuki

Keyword(s):

Positron Emission Tomography ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Fluorescence Detection ◽

High Performance ◽

Specific Radioactivity ◽

Emission Tomography ◽

Positron Emission ◽

Sensitive Determination

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Radiosynthesis of the candidate β-amyloid radioligand [11C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys

Synapse ◽

10.1002/syn.20782 ◽

2010 ◽

Vol 64 (10) ◽

pp. 733-741 ◽

Cited By ~ 21

Author(s):

Jan D. Andersson ◽

Katarina Varnäs ◽

Zsolt Cselényi ◽

Balázs Gulyás ◽

David Wensbo ◽

...

Keyword(s):

Positron Emission Tomography ◽

Emission Tomography ◽

Metabolite Analysis ◽

Cynomolgus Monkeys ◽

Positron Emission ◽

Positron Emission Tomography Examination ◽

Β Amyloid

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