Characterizing Short-Lived Protein Folding Intermediates by Top-Down Hydrogen Exchange Mass Spectrometry

Jingxi Pan; Jun Han; Christoph H. Borchers; Lars Konermann

doi:10.1021/ac101679j

Characterizing Short-Lived Protein Folding Intermediates by Top-Down Hydrogen Exchange Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac101679j ◽

2010 ◽

Vol 82 (20) ◽

pp. 8591-8597 ◽

Cited By ~ 65

Author(s):

Jingxi Pan ◽

Jun Han ◽

Christoph H. Borchers ◽

Lars Konermann

Keyword(s):

Mass Spectrometry ◽

Protein Folding ◽

Hydrogen Exchange ◽

Top Down ◽

Folding Intermediates ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Structure and Dynamics of Small Soluble Aβ(1–40) Oligomers Studied by Top-Down Hydrogen Exchange Mass Spectrometry

Biochemistry ◽

10.1021/bi3002049 ◽

2012 ◽

Vol 51 (17) ◽

pp. 3694-3703 ◽

Cited By ~ 51

Author(s):

Jingxi Pan ◽

Jun Han ◽

Christoph H. Borchers ◽

Lars Konermann

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Top Down ◽

Exchange Mass Spectrometry ◽

Structure And Dynamics ◽

Hydrogen Exchange Mass Spectrometry

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Application of Numerical Simulations to Extract Protein Folding Parameters from Hydrogen Exchange Mass Spectrometry Experiments under Native Conditions

Biophysical Journal ◽

10.1016/j.bpj.2018.11.1823 ◽

2019 ◽

Vol 116 (3) ◽

pp. 334a-335a

Author(s):

Jasper Flint ◽

Nilesh K. Aghera ◽

Raghavan Varadarajan ◽

Sheila Jaswal

Keyword(s):

Mass Spectrometry ◽

Protein Folding ◽

Numerical Simulations ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry ◽

Extract Protein

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Amide Hydrogen Exchange⧸Mass Spectrometry Applied to Cooperative Protein Folding: Equilibrium Unfolding of Staphylococcus aureus Aldolase

Methods in Enzymology - Energetics of Biological Macromolecules, Part E ◽

10.1016/s0076-6879(04)80013-2 ◽

2004 ◽

pp. 285-308 ◽

Cited By ~ 2

Author(s):

Hai Pan ◽

David L. Smith

Keyword(s):

Mass Spectrometry ◽

Staphylococcus Aureus ◽

Protein Folding ◽

Hydrogen Exchange ◽

Amide Hydrogen ◽

Amide Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry ◽

Equilibrium Unfolding

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Native State Hydrogen Exchange-Mass Spectrometry Methods to Probe Protein Folding and Unfolding

10.1007/978-1-0716-1716-8_8 ◽

2021 ◽

pp. 143-159

Author(s):

Pooja Malhotra ◽

Jayant B. Udgaonkar

Keyword(s):

Mass Spectrometry ◽

Protein Folding ◽

Hydrogen Exchange ◽

Native State ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Structural Analysis of Kinetic Folding Intermediates for a TIM Barrel Protein, Indole-3-glycerol Phosphate Synthase, by Hydrogen Exchange Mass Spectrometry and Gō Model Simulation

Journal of Molecular Biology ◽

10.1016/j.jmb.2007.09.024 ◽

2007 ◽

Vol 374 (2) ◽

pp. 528-546 ◽

Cited By ~ 30

Author(s):

Zhenyu Gu ◽

Maithreyi K. Rao ◽

William R. Forsyth ◽

John M. Finke ◽

C. Robert Matthews

Keyword(s):

Mass Spectrometry ◽

Structural Analysis ◽

Hydrogen Exchange ◽

Model Simulation ◽

Glycerol Phosphate ◽

Folding Intermediates ◽

Exchange Mass Spectrometry ◽

Go Model ◽

Tim Barrel ◽

Hydrogen Exchange Mass Spectrometry

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Top-Down Hydrogen Exchange Mass Spectrometry

Hydrogen Exchange Mass Spectrometry of Proteins ◽

10.1002/9781118703748.ch9 ◽

2016 ◽

pp. 149-164

Author(s):

Igor A. Kaltashov ◽

Rinat R. Abzalimov ◽

Guanbo Wang ◽

Cedric E. Bobst

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Top Down ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Monitoring the Folding Pathway of a Protein Over Evolutionary Time using Hydrogen Exchange - Mass Spectrometry (HX-MS)

Biophysical Journal ◽

10.1016/j.bpj.2017.11.350 ◽

2018 ◽

Vol 114 (3) ◽

pp. 54a

Author(s):

Eric Bolin ◽

Shion Lim ◽

Susan Marqusee

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Folding Pathway ◽

Evolutionary Time ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Structural Differences in Aβ Amyloid Protofibrils and Fibrils Mapped by Hydrogen Exchange – Mass Spectrometry with On-line Proteolytic Fragmentation

Journal of Molecular Biology ◽

10.1016/j.jmb.2006.06.066 ◽

2006 ◽

Vol 361 (4) ◽

pp. 785-795 ◽

Cited By ~ 98

Author(s):

Indu Kheterpal ◽

Maolian Chen ◽

Kelsey D. Cook ◽

Ronald Wetzel

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Exchange Mass Spectrometry ◽

Aβ Amyloid ◽

Structural Differences ◽

Hydrogen Exchange Mass Spectrometry ◽

On Line

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Label-Free, In-Solution Screening of Peptide Libraries for Binding to Protein Targets Using Hydrogen Exchange Mass Spectrometry

Journal of the American Chemical Society ◽

10.1021/jacs.5b11742 ◽

2016 ◽

Vol 138 (4) ◽

pp. 1335-1343 ◽

Cited By ~ 8

Author(s):

Walid S. Maaty ◽

David D. Weis

Keyword(s):

Mass Spectrometry ◽

Hydrogen Exchange ◽

Peptide Libraries ◽

Label Free ◽

Protein Targets ◽

Exchange Mass Spectrometry ◽

Hydrogen Exchange Mass Spectrometry

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Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody

mAbs ◽

10.1080/19420862.2015.1029217 ◽

2015 ◽

Vol 7 (3) ◽

pp. 525-539 ◽

Cited By ~ 44

Author(s):

Jayant Arora ◽

John M Hickey ◽

Ranajoy Majumdar ◽

Reza Esfandiary ◽

Steven M Bishop ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Hydrogen Exchange ◽

Dynamic Coupling ◽

Coupling Effects ◽

Exchange Mass Spectrometry ◽

Protein Interfaces ◽

Igg1 Monoclonal Antibody ◽

Hydrogen Exchange Mass Spectrometry ◽

Self Association

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