Deconvoluting Topography and Spatial Physiological Activity of Live Macrophage Cells by Scanning Electrochemical Microscopy in Constant-Distance Mode

2010 ◽  
Vol 82 (20) ◽  
pp. 8371-8373 ◽  
Author(s):  
Xiaocui Zhao ◽  
Piotr M. Diakowski ◽  
Zhifeng Ding
Keyword(s):  
Physiological Activity ◽  
Scanning Electrochemical Microscopy ◽  
Macrophage Cells ◽  
Constant Distance ◽  
Electrochemical Microscopy

4D Shearforce-Based Constant-Distance Mode Scanning Electrochemical Microscopy

2010 ◽  
Vol 82 (18) ◽  
pp. 7842-7848 ◽  
Author(s):  
Michaela Nebel ◽  
Kathrin Eckhard ◽  
Thomas Erichsen ◽  
Albert Schulte ◽  
Wolfgang Schuhmann
Keyword(s):  
Scanning Electrochemical Microscopy ◽  
Constant Distance ◽  
Electrochemical Microscopy

Feedback-Independent Pt Nanoelectrodes for Shear Force-Based Constant-Distance Mode Scanning Electrochemical Microscopy

2006 ◽  
Vol 78 (20) ◽  
pp. 7317-7324 ◽  
Author(s):  
Mathieu Etienne ◽  
Emily C. Anderson ◽  
Stephanie R. Evans ◽  
Wolfgang Schuhmann ◽  
Ingrid Fritsch
Keyword(s):  
Shear Force ◽  
Scanning Electrochemical Microscopy ◽  
Constant Distance ◽  
Electrochemical Microscopy

scholarly journals Recent Advances in Scanning Electrochemical Microscopy for Biological Applications

Materials ◽  
2018 ◽  
Vol 11 (8) ◽  
pp. 1389 ◽  
Author(s):  
Luyao Huang ◽  
Ziyu Li ◽  
Yuntian Lou ◽  
Fahe Cao ◽  
Dawei Zhang ◽  
...  
Keyword(s):  
Physiological Activity ◽  
Chemical Species ◽  
Scanning Electrochemical Microscopy ◽  
Living Cells ◽  
Basic Principles ◽  
Specific Chemical ◽  
Microscopy Technique ◽  
Biological Studies ◽  
Computer Controlled ◽  
Electrochemical Microscopy

Scanning electrochemical microscopy (SECM) is a chemical microscopy technique with high spatial resolution for imaging sample topography and mapping specific chemical species in liquid environments. With the development of smaller, more sensitive ultramicroelectrodes (UMEs) and more precise computer-controlled measurements, SECM has been widely used to study biological systems over the past three decades. Recent methodological breakthroughs have popularized SECM as a tool for investigating molecular-level chemical reactions. The most common applications include monitoring and analyzing the biological processes associated with enzymatic activity and DNA, and the physiological activity of living cells and other microorganisms. The present article first introduces the basic principles of SECM, followed by an updated review of the applications of SECM in biological studies on enzymes, DNA, proteins, and living cells. Particularly, the potential of SECM for investigating bacterial and biofilm activities is discussed.

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