Peptide Aptamers in Label-Free Protein Detection: 1. Characterization of the Immobilized Scaffold

2007 ◽  
Vol 79 (3) ◽  
pp. 1089-1096 ◽  
Author(s):  
Jason J. Davis ◽  
Jan Tkac ◽  
Sophie Laurenson ◽  
Paul Ko Ferrigno
Keyword(s):  
Protein Detection ◽  
Label Free ◽  
Peptide Aptamers ◽  
Free Protein

Peptide Aptamers in Label-Free Protein Detection: 2. Chemical Optimization and Detection of Distinct Protein Isoforms

2009 ◽  
Vol 81 (9) ◽  
pp. 3314-3320 ◽  
Author(s):  
Jason J. Davis ◽  
Jan Tkac ◽  
Rachel Humphreys ◽  
Anthony T. Buxton ◽  
Tracy A. Lee ◽  
...  
Keyword(s):  
Protein Detection ◽  
Protein Isoforms ◽  
Label Free ◽  
Peptide Aptamers ◽  
Free Protein

An electrochemical impedance biosensor with aptamer-modified pyrolyzed carbon electrode for label-free protein detection

2008 ◽  
Vol 129 (1) ◽  
pp. 372-379 ◽  
Author(s):  
Jung A Lee ◽  
Seongpil Hwang ◽  
Juhyoun Kwak ◽  
Se Il Park ◽  
Seung S. Lee ◽  
...  
Keyword(s):  
Electrochemical Impedance ◽  
Protein Detection ◽  
Carbon Electrode ◽  
Label Free ◽  
Free Protein

An Optical Nanoruler Based on a Conjugated Polymer−Silver Nanoprism Pair for Label-Free Protein Detection

2015 ◽  
Vol 27 (39) ◽  
pp. 6040-6045 ◽  
Author(s):  
Xiaoyu Wang ◽  
Shengliang Li ◽  
Pengbo Zhang ◽  
Fengting Lv ◽  
Libing Liu ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Protein Detection ◽  
Label Free ◽  
Free Protein

Protein Detection: An Optical Nanoruler Based on a Conjugated Polymer−Silver Nanoprism Pair for Label-Free Protein Detection (Adv. Mater. 39/2015)

2015 ◽  
Vol 27 (39) ◽  
pp. 6039-6039 ◽  
Author(s):  
Xiaoyu Wang ◽  
Shengliang Li ◽  
Pengbo Zhang ◽  
Fengting Lv ◽  
Libing Liu ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Protein Detection ◽  
Label Free ◽  
Free Protein

scholarly journals Proteomic Characterization of Cerebrospinal Fluid from Ataxia-Telangiectasia (A-T) Patients Using a LC/MS-Based Label-Free Protein Quantification Technology

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Monika Dzieciatkowska ◽  
Guihong Qi ◽  
Jinsam You ◽  
Kerry G. Bemis ◽  
Heather Sahm ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Biomarker Discovery ◽  
Functional Characterization ◽  
Therapeutic Targets ◽  
Bioinformatic Analysis ◽  
Protein Quantification ◽  
Label Free ◽  
Free Protein ◽  
Potential Biomarker

Cerebrospinal fluid (CSF) has been used for biomarker discovery of neurodegenerative diseases in humans since biological changes in the brain can be seen in this biofluid. Inactivation of A-T-mutated protein (ATM), a multifunctional protein kinase, is responsible for A-T, yet biochemical studies have not succeeded in conclusively identifying the molecular mechanism(s) underlying the neurodegeneration seen in A-T patients or the proteins that can be used as biomarkers for neurologic assessment of A-T or as potential therapeutic targets. In this study, we applied a high-throughput LC/MS-based label-free protein quantification technology to quantitatively characterize the proteins in CSF samples in order to identify differentially expressed proteins that can serve as potential biomarker candidates for A-T. Among 204 identified CSF proteins with high peptide-identification confidence, thirteen showed significant protein expression changes. Bioinformatic analysis revealed that these 13 proteins are either involved in neurodegenerative disorders or cancer. Future molecular and functional characterization of these proteins would provide more insights into the potential therapeutic targets for the treatment of A-T and the biomarkers that can be used to monitor or predict A-T disease progression. Clinical validation studies are required before any of these proteins can be developed into clinically useful biomarkers.

Label-free protein detection using a microfluidic Coulter-counter device

2014 ◽  
Vol 190 ◽  
pp. 922-927 ◽  
Author(s):  
Romen Rodriguez-Trujillo ◽  
Mohammad A. Ajine ◽  
Alice Orzan ◽  
Mikkel D. Mar ◽  
Flemming Larsen ◽  
...  
Keyword(s):  
Protein Detection ◽  
Coulter Counter ◽  
Label Free ◽  
Free Protein

scholarly journals Functionalized etched tilted fiber Bragg grating aptasensor for label-free protein detection

2019 ◽  
Vol 146 ◽  
pp. 111765 ◽  
Author(s):  
Marzhan Sypabekova ◽  
Sanzhar Korganbayev ◽  
Álvaro González-Vila ◽  
Christophe Caucheteur ◽  
Madina Shaimerdenova ◽  
...  
Keyword(s):  
Fiber Bragg Grating ◽  
Protein Detection ◽  
Bragg Grating ◽  
Label Free ◽  
Free Protein

Direct-writing colloidal photonic crystal microfluidic chips by inkjet printing for label-free protein detection

Lab on a Chip ◽  
2012 ◽  
Vol 12 (17) ◽  
pp. 3089 ◽  
Author(s):  
Weizhi Shen ◽  
Mingzhu Li ◽  
Changqing Ye ◽  
Lei Jiang ◽  
Yanlin Song
Keyword(s):  
Photonic Crystal ◽  
Inkjet Printing ◽  
Protein Detection ◽  
Microfluidic Chips ◽  
Label Free ◽  
Direct Writing ◽  
Free Protein
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