Dual-Capillary Backscatter Interferometry for High-Sensitivity Nanoliter-Volume Refractive Index Detection with Density Gradient Compensation

2005 ◽  
Vol 77 (24) ◽  
pp. 7872-7877 ◽  
Author(s):  
Zhanling Wang ◽  
Darryl J. Bornhop
Keyword(s):  
Refractive Index ◽  
Density Gradient ◽  
High Sensitivity ◽  
Gradient Compensation ◽  
Refractive Index Detection

Bent optical fiber taper for refractive index detection with a high sensitivity

2013 ◽  
Vol 201 ◽  
pp. 352-356 ◽  
Author(s):  
Guigen Liu ◽  
Kaiwei Li ◽  
Peng Hao ◽  
Wenchao Zhou ◽  
Yihui Wu ◽  
...  
Keyword(s):  
Refractive Index ◽  
Optical Fiber ◽  
High Sensitivity ◽  
Fiber Taper ◽  
Optical Fiber Taper ◽  
Refractive Index Detection

scholarly journals Differentiating and quantifying exosome secretion from a single cell using quasi-bound states in the continuum

Nanophotonics ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1081-1086 ◽  
Author(s):  
Abdoulaye Ndao ◽  
Liyi Hsu ◽  
Wei Cai ◽  
Jeongho Ha ◽  
Junhee Park ◽  
...  
Keyword(s):  
Single Cell ◽  
Optical Sensors ◽  
Figure Of Merit ◽  
Bound States ◽  
Single Cell Analysis ◽  
Optical Cavity ◽  
High Sensitivity ◽  
Cell Secretion ◽  
The Continuum ◽  
Refractive Index Detection

AbstractOne of the key challenges in biology is to understand how individual cells process information and respond to perturbations. However, most of the existing single-cell analysis methods can only provide a glimpse of cell properties at specific time points and are unable to provide cell secretion and protein analysis at single-cell resolution. To address the limits of existing methods and to accelerate discoveries from single-cell studies, we propose and experimentally demonstrate a new sensor based on bound states in the continuum to quantify exosome secretion from a single cell. Our optical sensors demonstrate high-sensitivity refractive index detection. Because of the strong overlap between the medium supporting the mode and the analytes, such an optical cavity has a figure of merit of 677 and sensitivity of 440 nm/RIU. Such results facilitate technological progress for highly conducive optical sensors for different biomedical applications.

scholarly journals Highly Sensitive D-Shaped Plasmonic Refractive Index Sensor for a Broad Range of Refractive Index Detection

2021 ◽  
Vol 13 (1) ◽  
pp. 1-11
Author(s):  
Emranul Haque ◽  
Abdullah Al Noman ◽  
Md. Anwar Hossain ◽  
Nguyen Hoang Hai ◽  
Yoshinori Namihira ◽  
...  
Keyword(s):  
Refractive Index ◽  
Refractive Index Sensor ◽  
Highly Sensitive ◽  
Refractive Index Detection

scholarly journals Hybrid Grating in Reduced-Diameter Fiber for Temperature-Calibrated High-Sensitivity Refractive Index Sensing

2019 ◽  
Vol 9 (9) ◽  
pp. 1923
Author(s):  
Biqiang Jiang ◽  
Zhen Hao ◽  
Dingyi Feng ◽  
Kaiming Zhou ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Refractive Index ◽  
Simultaneous Measurement ◽  
Surrounding Medium ◽  
High Sensitivity ◽  
Fiber Grating ◽  
Bragg Resonance ◽  
Core Mode ◽  
Promising Alternative ◽  
Sensing Applications ◽  
Highly Sensitive

We propose and experimentally demonstrate a hybrid grating, in which an excessively tilted fiber grating (Ex-TFG) and a fiber Bragg grating (FBG) were co-inscribed in a reduced-diameter fiber (RDF). The hybrid grating showed strong resonances due to coupling among core mode and a set of polarization-dependent cladding modes. This coupling showed enhanced evanescent fields by the reduced cladding size, thus allowing stronger interaction with the surrounding medium. Moreover, the FBG’s Bragg resonance confined by the thick cladding was exempt from the change of the surrounding medium’s refractive index (RI), and then the FBG can work as a temperature compensator. As a result, the Ex-TFG in RDF promised a highly sensitive RI measurement, with a sensitivity up to ~1224 nm/RIU near the RI of 1.38. Through simultaneous measurement of temperature and RI, the temperature dependence of water’s RI is then determined. Therefore, the proposed hybrid grating with a spectrum of multi-peaks embedded with a sharp Bragg resonance is a promising alternative for the simultaneous measurement of multi-parameters for many RI-based sensing applications.

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