Simultaneous Time-of-Flight Secondary Ion MS Quantitative Analysis of Drug Surface Concentration and Polymer Degradation Kinetics in Biodegradable Poly(l-lactic acid) Blends

2003 ◽  
Vol 75 (13) ◽  
pp. 2950-2958 ◽  
Author(s):  
Joo-Woon Lee ◽  
Joseph A. Gardella
Keyword(s):  
Lactic Acid ◽  
Quantitative Analysis ◽  
Degradation Kinetics ◽  
Time Of Flight ◽  
Polymer Degradation ◽  
Surface Concentration ◽  
Biodegradable Poly ◽  
Secondary Ion

Time-of-Flight Secondary Ion Mass Spectrometry Studies of Hydrolytic Degradation Kinetics at the Surface of Poly(glycolic acid)

2000 ◽  
Vol 33 (13) ◽  
pp. 4726-4732 ◽  
Author(s):  
Jiaxing Chen ◽  
Joo-Woon Lee ◽  
Norma L. Hernandez de Gatica ◽  
Cindy A. Burkhardt ◽  
David M. Hercules ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Glycolic Acid ◽  
Secondary Ion Mass Spectrometry ◽  
Degradation Kinetics ◽  
Time Of Flight ◽  
Hydrolytic Degradation ◽  
Ion Mass Spectrometry ◽  
Secondary Ion

Applications of Time-OF-Flight Secondary Ion Mass Spectrometry (TOF-SIMS)

1990 ◽  
Vol 48 (2) ◽  
pp. 308-309
Author(s):  
Bruno Schueler ◽  
Robert W. Odom
Keyword(s):  
Mass Spectrometry ◽  
Secondary Ion Mass Spectrometry ◽  
Structural Information ◽  
Time Of Flight ◽  
Biological Tissues ◽  
Polymer Surfaces ◽  
Tof Sims ◽  
Secondary Ions ◽  
Ion Mass Spectrometry ◽  
Secondary Ion

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) provides unique capabilities for elemental and molecular compositional analysis of a wide variety of surfaces. This relatively new technique is finding increasing applications in analyses concerned with determining the chemical composition of various polymer surfaces, identifying the composition of organic and inorganic residues on surfaces and the localization of molecular or structurally significant secondary ions signals from biological tissues. TOF-SIMS analyses are typically performed under low primary ion dose (static SIMS) conditions and hence the secondary ions formed often contain significant structural information.This paper will present an overview of current TOF-SIMS instrumentation with particular emphasis on the stigmatic imaging ion microscope developed in the authors’ laboratory. This discussion will be followed by a presentation of several useful applications of the technique for the characterization of polymer surfaces and biological tissues specimens. Particular attention in these applications will focus on how the analytical problem impacts the performance requirements of the mass spectrometer and vice-versa.

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