On-Line Liquid Chromatography-Accurate Radioisotope Counting Coupled with a Radioactivity Detector and Mass Spectrometer for Metabolite Identification in Drug Discovery and Development

A.-E. F. Nassar; S. M. Bjorge; D. Y. Lee

doi:10.1021/ac025934f

On-Line Liquid Chromatography-Accurate Radioisotope Counting Coupled with a Radioactivity Detector and Mass Spectrometer for Metabolite Identification in Drug Discovery and Development

Analytical Chemistry ◽

10.1021/ac025934f ◽

2003 ◽

Vol 75 (4) ◽

pp. 785-790 ◽

Cited By ~ 49

Author(s):

A.-E. F. Nassar ◽

S. M. Bjorge ◽

D. Y. Lee

Keyword(s):

Liquid Chromatography ◽

Drug Discovery ◽

Mass Spectrometer ◽

Metabolite Identification ◽

Drug Discovery And Development ◽

Radioactivity Detector ◽

On Line

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A systematic approach to development of analytical scale and microflow-based liquid chromatography coupled to mass spectrometry metabolomics methods to support drug discovery and development

Journal of Chromatography A ◽

10.1016/j.chroma.2021.462047 ◽

2021 ◽

Vol 1642 ◽

pp. 462047

Author(s):

Sarah Geller ◽

Harvey Lieberman ◽

Alla Kloss ◽

Alexander R. Ivanov

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Drug Discovery ◽

Systematic Approach ◽

Drug Discovery And Development ◽

Analytical Scale

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Identification of new transformation products during enzymatic treatment of tetracycline and erythromycin antibiotics at laboratory scale by an on-line turbulent flow liquid-chromatography coupled to a high resolution mass spectrometer LTQ-Orbitrap

Chemosphere ◽

10.1016/j.chemosphere.2014.05.072 ◽

2015 ◽

Vol 119 ◽

pp. 90-98 ◽

Cited By ~ 49

Author(s):

Marta Llorca ◽

Sara Rodríguez-Mozaz ◽

Olivier Couillerot ◽

Karine Panigoni ◽

Jean de Gunzburg ◽

...

Keyword(s):

Liquid Chromatography ◽

High Resolution ◽

Turbulent Flow ◽

Mass Spectrometer ◽

Transformation Products ◽

Enzymatic Treatment ◽

Laboratory Scale ◽

On Line ◽

High Resolution Mass Spectrometer ◽

Resolution Mass

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Online Hydrogen-Deuterium Exchange and a Tandem-Quadrupole Time-of-Flight Mass Spectrometer Coupled with Liquid Chromatography for Metabolite Identification in Drug Metabolism

Journal of Chromatographic Science ◽

10.1093/chromsci/41.8.398 ◽

2003 ◽

Vol 41 (8) ◽

pp. 398-404 ◽

Cited By ~ 32

Author(s):

A.- E. F. Nassar

Keyword(s):

Liquid Chromatography ◽

Drug Metabolism ◽

Mass Spectrometer ◽

Time Of Flight ◽

Metabolite Identification ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Flight Mass Spectrometer ◽

Hydrogen Deuterium ◽

Tandem Quadrupole

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Application of on-line nano-liquid chromatography/mass spectrometry in metabolite identification studies

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.5332 ◽

2012 ◽

Vol 26 (3) ◽

pp. 320-326 ◽

Cited By ~ 10

Author(s):

Jingzhou Liu ◽

Zhiyang Zhao ◽

Yohannes Teffera

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Metabolite Identification ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

On Line ◽

Nano Liquid Chromatography

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Exact Mass Measurements On-Line with High-Performance Liquid Chromatography on a Quadrupole Mass Spectrometer

Analytical Chemistry ◽

10.1021/ac0006728 ◽

2001 ◽

Vol 73 (3) ◽

pp. 589-595 ◽

Cited By ~ 11

Author(s):

Thomas Storm ◽

Claudia Hartig ◽

Thorsten Reemtsma ◽

Martin Jekel

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Mass Spectrometer ◽

High Performance ◽

Quadrupole Mass Spectrometer ◽

Quadrupole Mass ◽

Mass Measurements ◽

Exact Mass ◽

On Line

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Software aided approaches to structure-based metabolite identification in drug discovery and development

Drug Discovery Today Technologies ◽

10.1016/j.ddtec.2012.12.001 ◽

2013 ◽

Vol 10 (1) ◽

pp. e207-e217 ◽

Cited By ~ 18

Author(s):

Axel Pähler ◽

Andreas Brink

Keyword(s):

Drug Discovery ◽

Metabolite Identification ◽

Drug Discovery And Development

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Drug metabolite identification using ultrahigh‐performance liquid chromatography–ultraviolet spectroscopy and parallelized scans on a tribrid Orbitrap mass spectrometer

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.8735 ◽

2020 ◽

Vol 34 (10) ◽

Cited By ~ 2

Author(s):

Stephen D. Wilkinson ◽

Scott Martin ◽

Alexandra L. Orton ◽

Roshini Markandu ◽

Barry C. Jones

Keyword(s):

Liquid Chromatography ◽

Mass Spectrometer ◽

Metabolite Identification ◽

Ultraviolet Spectroscopy ◽

Drug Metabolite ◽

Orbitrap Mass Spectrometer ◽

Ultrahigh Performance Liquid Chromatography

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Liquid chromatography?mass spectrometry in peptide drug discovery and development

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-004-2868-7 ◽

2004 ◽

Vol 381 (1) ◽

pp. 51-53 ◽

Cited By ~ 16

Author(s):

Harald John

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Drug Discovery ◽

Peptide Drug ◽

Liquid Chromatography Mass Spectrometry ◽

Drug Discovery And Development ◽

Chromatography Mass Spectrometry

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Direct on-line hyphenation of capillary liquid chromatography to nuclear magnetic resonance spectroscopy: Practical aspects and application to drug metabolite identification

Journal of Chromatography A ◽

10.1016/j.chroma.2003.11.105 ◽

2004 ◽

Vol 1028 (2) ◽

pp. 259-266 ◽

Cited By ~ 13

Author(s):

Martin Sandvoss ◽

Andy D. Roberts ◽

Ismail M. Ismail ◽

Stephanie E. North

Keyword(s):

Nuclear Magnetic Resonance ◽

Liquid Chromatography ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Metabolite Identification ◽

Capillary Liquid Chromatography ◽

Resonance Spectroscopy ◽

On Line ◽

Capillary Liquid

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An automated on-line turbulent flow liquid-chromatography technology coupled to a high resolution mass spectrometer LTQ-Orbitrap for suspect screening of antibiotic transformation products during microalgae wastewater treatment

Journal of Chromatography A ◽

10.1016/j.chroma.2018.06.027 ◽

2018 ◽

Vol 1568 ◽

pp. 57-68 ◽

Cited By ~ 19

Author(s):

Adrián Jaén-Gil ◽

Andrea Hom-Diaz ◽

Marta Llorca ◽

Teresa Vicent ◽

Paqui Blánquez ◽

...

Keyword(s):

Wastewater Treatment ◽

Liquid Chromatography ◽

High Resolution ◽

Turbulent Flow ◽

Mass Spectrometer ◽

Transformation Products ◽

Suspect Screening ◽

On Line ◽

High Resolution Mass Spectrometer ◽

Resolution Mass

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