scholarly journals In Vivo Biocompatibility and Analytical Performance of Intravascular Amperometric Oxygen Sensors Prepared with Improved Nitric Oxide-Releasing Silicone Rubber Coating

2003 ◽  
Vol 75 (4) ◽  
pp. 1037-1037
Author(s):  
Megan C. Frost ◽  
Steven M. Rudich ◽  
Huiping Zhang ◽  
Martin A. Maraschio ◽  
Mark E. Meyerhoff
Keyword(s):  
Nitric Oxide ◽  
Silicone Rubber ◽  
Oxygen Sensors ◽  
Analytical Performance ◽  
Rubber Coating ◽  
Nitric Oxide Releasing

In Vivo Biocompatibility and Analytical Performance of Intravascular Amperometric Oxygen Sensors Prepared with Improved Nitric Oxide-Releasing Silicone Rubber Coating

2002 ◽  
Vol 74 (23) ◽  
pp. 5942-5947 ◽  
Author(s):  
Megan C. Frost ◽  
Steven M. Rudich ◽  
Huiping Zhang ◽  
Martín A. Maraschio ◽  
Mark E. Meyerhoff
Keyword(s):  
Nitric Oxide ◽  
Silicone Rubber ◽  
Oxygen Sensors ◽  
Analytical Performance ◽  
Rubber Coating ◽  
Nitric Oxide Releasing

scholarly journals In Vivo Analytical Performance of Nitric Oxide-Releasing Glucose Biosensors

2014 ◽  
Vol 86 (14) ◽  
pp. 7141-7149 ◽  
Author(s):  
Robert J. Soto ◽  
Benjamin J. Privett ◽  
Mark H. Schoenfisch
Keyword(s):  
Nitric Oxide ◽  
Analytical Performance ◽  
Glucose Biosensors ◽  
Nitric Oxide Releasing

scholarly journals 536 In vitro and in vivo efficacy of nitric oxide-releasing antiviral therapeutic agents

2016 ◽  
Vol 136 (5) ◽  
pp. S95
Author(s):  
K.A. McHale ◽  
K. Balogh ◽  
H. Wang ◽  
S. Hollenbach ◽  
N. Christensen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Therapeutic Agents ◽  
In Vivo Efficacy ◽  
Nitric Oxide Releasing

In Vivo Antithrombotic Effects of a Nitric Oxide-Releasing Aspirin Derivative, NCX-4016

1999 ◽  
Vol 93 (1) ◽  
pp. 43-50 ◽  
Author(s):  
John L. Wallace ◽  
Marcelo N. Muscara ◽  
Webb McKnight ◽  
Michael Dicay ◽  
Piero Del Soldato ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antithrombotic Effects ◽  
Nitric Oxide Releasing ◽  
Ncx 4016

scholarly journals Novel Photoinitiated Nitric Oxide Releasing Compounds for More Biocompatible Coatings on Blood and Tissue Contacting Medical Devices

2009 ◽  
Vol 3 (2) ◽  
Author(s):  
B. M. Burgess ◽  
G. E. Gierke ◽  
M. C. Frost
Keyword(s):  
Nitric Oxide ◽  
Thrombus Formation ◽  
Neointimal Hyperplasia ◽  
Vascular Grafts ◽  
Blood Gases ◽  
Surface Fluxes ◽  
Biomedical Devices ◽  
Polymer Fillers ◽  
Nitric Oxide Releasing

Biomedical devices that contact blood and tissue universally inspire a host response that often compromises the function of the device (i.e., intravascular sensors become coated with thrombi, artificial vascular grafts become coated with thrombi, artificial vascular grafts become occluded with thrombus formation and neointimal hyperplasia). Nitric oxide (NO) has been shown to be a potent inhibitor of platelet adhesion and activation and has been implicated in mediating the inflammatory response and promoting would healing. We are currently developing NO-releasing compounds based on S-nitrosothiols derived from substituted aromatic compounds that utilize light as an external on/off trigger capable of releasing precisely controlled surface fluxes of NO. The level of NO generated is dependent on the wavelength and intensity of light shown on the compounds. Data will be presented that show the synthesis and NO-release properties of three novel compounds, S-nitroso-2-methoxybenzene, S-nitroso-3-methoxybenzene and S-nitroso-2-chlorobenzene. Ultimately, these compounds will be tethered to the surface of polymer fillers that will then be blended into hydrophobic polymers and used as coatings on biomedical devices. A model system that will be used to demonstrate the utility of this approach will be a multi-element fiber optic sensors that will contain sensing elements capable of measuring blood gases and NO-releasing fibers that locally generate enough NO to inhibit clot formation on the sensor surface, thus allowing the sensor to function reliably in vivo.

scholarly journals Nitric Oxide-Releasing Aspirin Suppresses NF-κB Signaling in Estrogen Receptor Negative Breast Cancer Cells in Vitro and in Vivo

Molecules ◽  
2015 ◽  
Vol 20 (7) ◽  
pp. 12481-12499 ◽  
Author(s):  
Niharika Nath ◽  
Mitali Chattopadhyay ◽  
Deborah Rodes ◽  
Anna Nazarenko ◽  
Ravinder Kodela ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nitric Oxide ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Nitric Oxide Releasing ◽  
Estrogen Receptor Negative

scholarly journals The preparation and characterization of nitric oxide releasing silicone rubber materials impregnated with S-nitroso-tert-dodecyl mercaptan

2016 ◽  
Vol 4 (3) ◽  
pp. 422-430 ◽  
Author(s):  
Alex R. Ketchum ◽  
Michael P. Kappler ◽  
Jianfeng Wu ◽  
Chuanwu Xi ◽  
Mark E. Meyerhoff
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Activity ◽  
Silicone Rubber ◽  
Storage Stability ◽  
No Release ◽  
Nitric Oxide Releasing ◽  
Dodecyl Mercaptan

Silicone rubber catheters impregnated with S-nitroso-tert-dodecylmercaptan demonstrate long term NO release, minimal leaching, considerable antimicrobial activity, and reasonable storage stability.

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