Application of Cyclam-Capped β-Cyclodextrin-Bonded Silica Particles as a Chiral Stationary Phase in Capillary Electrochromatography for Enantiomeric Separations

2003 ◽  
Vol 75 (6) ◽  
pp. 1348-1354 ◽  
Author(s):  
Yinhan Gong ◽  
Hian Kee Lee
Keyword(s):  
Stationary Phase ◽  
Capillary Electrochromatography ◽  
Chiral Stationary Phase ◽  
Silica Particles ◽  
Enantiomeric Separations

Enantiomeric Separation of 1-Phenyl-1-Propanol Using Calix[4]Arene-Capped β-Cyclodextrin-Bonded Silica Particles as Chiral Stationary Phase in Capillary Electrochromatography

2013 ◽  
Vol 749 ◽  
pp. 304-308 ◽  
Author(s):  
Jia Zhao ◽  
Jun Li ◽  
E.L. Yong ◽  
Yin Han Gong
Keyword(s):  
Stationary Phase ◽  
Capillary Electrochromatography ◽  
Chiral Stationary Phase ◽  
Enantiomeric Separation ◽  
Silica Particles ◽  
Hydroxyl Groups ◽  
New Type ◽  
Phenolic Hydroxyl Groups ◽  
First Time ◽  
Calix Arene

A new type of calix [ arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy) propylsilyl-appended silica particles (C4CD-HPS) has been successfully used as chiral stationary phase (CSP) in capillary electrochromatography (CEC) for separation of enantiomers of 1-phenyl-1-propanol for the first time. C4CD-HPS contains a chiral selector with two recognition sites: calix [arene and β-cyclodextrin. Due to the cooperative functioning of the calix [arene and β-cyclodextrin, C4CD-HPS has exhibited excellent enantioselectivity for the enantiomers of 1-phenyl-1-propanol. After the multiple phenolic hydroxyl groups in the calix [arene moieties are ionized in the running buffer, the bonded stationary phase C4CD-HPS becomes negatively-charged to provide high electroosmotic flow (EOF) in CEC. Fast and high-resolution separation for enantiomers of 1-phenyl-1-propanol has been easily achieved on C4CD-HPS. This new type of chiral stationary phase has exhibited great potential for fast enantiomeric separations in CEC.

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