Optical Imaging Fiber-Based Single Live Cell Arrays:  A High-Density Cell Assay Platform

2002 ◽  
Vol 74 (13) ◽  
pp. 3046-3054 ◽  
Author(s):  
Israel Biran ◽  
David R. Walt
Keyword(s):  
Optical Imaging ◽  
High Density ◽  
Live Cell ◽  
Cell Assay ◽  
Cell Arrays ◽  
High Density Cell

scholarly journals High-Density Cell Arrays for Genome-Scale Phenotypic Screening

2019 ◽  
Vol 24 (3) ◽  
pp. 274-283 ◽  
Author(s):  
Vytaute Starkuviene ◽  
Stefan M. Kallenberger ◽  
Nina Beil ◽  
Tautvydas Lisauskas ◽  
Bastian So-Song Schumacher ◽  
...  
Keyword(s):  
New Technologies ◽  
High Density ◽  
Cell Array ◽  
Preclinical Development ◽  
Single Experiment ◽  
Efficient Manner ◽  
Cell Arrays ◽  
High Density Cell ◽  
High Degree ◽  
Genome Scale

Due to high associated costs and considerable time investments of cell-based screening, there is a strong demand for new technologies that enable preclinical development and tests of diverse biologicals in a cost-saving and time-efficient manner. For those reasons we developed the high-density cell array (HD-CA) platform, which miniaturizes cell-based screening in the form of preprinted and ready-to-run screening arrays. With the HD-CA technology, up to 24,576 samples can be tested in a single experiment, thereby saving costs and time for microscopy-based screening by 75%. Experiments on the scale of the entire human genome can be addressed in a real parallel manner, with screening campaigns becoming more comfortable and devoid of robotics infrastructure on the user side. The high degree of miniaturization enables working with expensive reagents and rare and difficult-to-obtain cell lines. We have also optimized an automated imaging procedure for HD-CA and demonstrate the applicability of HD-CA to CRISPR-Cas9- and RNAi-mediated phenotypic assessment of the gene function.

Planar optical sensors: A tool for screening enzyme activity in high density cell arrays

2006 ◽  
Vol 114 (2) ◽  
pp. 984-994 ◽  
Author(s):  
Jochen Gerlach ◽  
Brigitte Pohn ◽  
Wolfgang Karl ◽  
Marcel Scheideler ◽  
Martina Uray ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Optical Sensors ◽  
High Density ◽  
Cell Arrays ◽  
High Density Cell

scholarly journals hFUT1-Based Live-Cell Assay To Profile α1-2-Fucoside-Enhanced Influenza Virus A Infection

2020 ◽  
Vol 15 (4) ◽  
pp. 819-823 ◽  
Author(s):  
Senlian Hong ◽  
Geramie Grande ◽  
Chenhua Yu ◽  
Digantkumar G. Chapla ◽  
Natalie Reigh ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Live Cell ◽  
Influenza Virus A ◽  
Cell Assay

High density cell culture ofRhodotorula glutinis using oxygen-enriched air

1986 ◽  
Vol 8 (10) ◽  
pp. 715-718 ◽  
Author(s):  
Jae Gu Pan ◽  
Moo Young Kwak ◽  
Joon Shick Rhee
Keyword(s):  
Cell Culture ◽  
High Density ◽  
High Density Cell ◽  
High Density Cell Culture
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