Effect of Analyte Adsorption on the Electroosmotic Flow in Microfluidic Channels

2002 ◽  
Vol 74 (4) ◽  
pp. 771-775 ◽  
Author(s):  
Sandip Ghosal
Author(s):  
M. T. Blom ◽  
E. F. Hasselbrink ◽  
H. Wensink ◽  
A. van den Berg

2006 ◽  
Vol 34 ◽  
pp. 925-930 ◽  
Author(s):  
G Y Tang ◽  
D G Yan ◽  
C Yang ◽  
H Q Gong ◽  
C J Chai ◽  
...  

2004 ◽  
Vol 76 (17) ◽  
pp. 4945-4950 ◽  
Author(s):  
Samuel P. Forry ◽  
Jacqueline R. Murray ◽  
Michael L. A. V. Heien ◽  
Laurie E. Locascio ◽  
R. Mark Wightman

2018 ◽  
Vol 30 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Mithilesh Kumar Chaube ◽  
Ashu Yadav ◽  
Dharmendra Tripathi ◽  
O. Anwar Bég

Author(s):  
Yee Cheong Lam ◽  
Gongyue Tang ◽  
Deguang Yan

To study the effect of geometry on electroosmotic flow in micro channels, we fabricated PDMS-glass microchannels of different designs, which have patterned channels with abrupt contraction of different sizes. Using fluorescent imaging technology, we demonstrated the effect of geometry on the instability of DC driven electroosmotic flow in microfluidic channels. For certain geometry and conductivity of the electrolyte solution (Sodium Bicarbonate), there is a threshold voltage for electroosmotic instability, exhibiting itself as “ripple”. Generally, the factors which affect the threshold voltage include channel width, channel geometry, and electrolyte conductivity. Narrower channel resulted in higher onset voltage. As conductivity of the electrolyte increases, the threshold voltage tends to increase. Early transition to unstable electroosmotic flow in microfluidic channels was observed under relatively low Re.


Soft Matter ◽  
2017 ◽  
Vol 13 (41) ◽  
pp. 7498-7504 ◽  
Author(s):  
Alexander L. Dubov ◽  
Taras Y. Molotilin ◽  
Olga I. Vinogradova

A novel fractionation concept is proposed for spherical particles in grooved microfluidic channels with an electroosmotic flow.


Author(s):  
Shaurya Prakash ◽  
Timothy M. Long ◽  
Jonathan Wan ◽  
Jeffrey S. Moore ◽  
Mark A. Shannon

A rapid, facile, and modular surface modification scheme for the covalent attachment of pre-formed polymer moieties to self-assembled monolayers via ‘click’ chemistry within glass microfluidic channels (3 cm long, 110 μm wide and 15 μm deep) is described. The effect that different moieties have on the electroosmotic flow (EOF) within the microchannels is evaluated. The application of linear polymers such as poly(ethylene glycol) (PEG) generates hydrophilic surfaces that reduce the analyte-wall interactions, thereby increasing separation efficiency and improving resolution, especially in bio-separations. Dendritic polymers such as poly(amido amine) (PAMAM) on channel walls can provide high-surface area structures with tunable surface charge depending on the generation of the dendrimer coating. Modified surfaces are characterized by X-ray photoelectron spectroscopy (XPS), Fourier Transform Infrared-Attenuated Total Reflection spectroscopy (FTIR-ATR), and contact angle measurements. EOF measurements in modified and unmodified channels provide information about wall-analyte interactions. A PAMAM dendrimer coated channel presents an amine terminated surface with a positive charge in contrast to a negatively charged bare-glass surface. Use of surface coatings can lead to an increase of the EOF by 15% as is the case for an azide terminated surface or reverse the direction of EOF as is the case for the PAMAM coatings by changing the surface charge polarity.


Author(s):  
Deguang Yan ◽  
Chun Yang ◽  
Xiaoyang Huang

In electrokinetically-driven microfluidic applications, reservoirs are indispensable and have finite sizes. During operating processes, as the liquid level in reservoirs keeps changing as time elapses, a backpressure is generated. Thus, the flow in microfluidic channels actually exhibits a combination of the electroosmotic flow and the time-dependent induced backpressure-driven flow. In this paper, a model is presented to describe the effect of the finite reservoir size on electroosmotic flow in a rectangular microchannel. Important parameters that describe the effect of finite reservoir size on flow characteristics are discussed. A new concept termed as “effective pumping period” is introduced to characterize the reservoir size effect. The proposed model identifies the mechanisms of the finite-reservoir size effects and is verified by experiment using the micro-PIV technique. The results reported in this study can be used for facilitating the design of microfluidic devices.


2006 ◽  
Vol 27 (3) ◽  
pp. 628-639 ◽  
Author(s):  
Gongyue Tang ◽  
Deguang Yan ◽  
Chun Yang ◽  
Haiqing Gong ◽  
John Chee Chai ◽  
...  

Langmuir ◽  
2003 ◽  
Vol 19 (23) ◽  
pp. 9792-9798 ◽  
Author(s):  
Bin Wang ◽  
Lu Chen ◽  
Zamin Abdulali-Kanji ◽  
J. Hugh Horton ◽  
Richard D. Oleschuk

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