Hydroxylation of aromatic hydrocarbons in mass spectrometer ion sources under atmospheric pressure ionization and chemical ionization conditions

1983 ◽  
Vol 55 (14) ◽  
pp. 2272-2275 ◽  
Author(s):  
Nels H. Mahle ◽  
R. G. Cooks ◽  
R. W. Korzeniowski
Keyword(s):  
Mass Spectrometer ◽  
Aromatic Hydrocarbons ◽  
Atmospheric Pressure ◽  
Chemical Ionization ◽  
Ion Sources ◽  
Atmospheric Pressure Ionization

Isolation of Drugs and Drug Metabolites from Biological Fluids by Use of Salt-Solvent Pairs

1974 ◽  
Vol 20 (2) ◽  
pp. 282-287 ◽  
Author(s):  
M G Horning ◽  
P Gregory ◽  
J Nowlin ◽  
M Stafford ◽  
K Lertratanangkoon ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Chemical Ionization ◽  
Ammonium Carbonate ◽  
Biological Fluids ◽  
Ionization Mass ◽  
Atmospheric Pressure Ionization ◽  
Internal Standards ◽  
Drug Metabolites ◽  
Ionization Mode ◽  
Selective Ion Detection

Abstract Simple rapid procedures based on salt-solvent pairs have been developed for the isolation of drugs and drug metabolites from urine, plasma, and breast milk. The best overall recovery of drugs (84-104%) was obtained by using ammonium carbonate—ethyl acetate extraction. Internal standards were added to the biological samples before the isolation procedure was begun; standards labeled with stable isotopes were preferred. The isolated drugs were quantitated by selective ion detection, with use of an LKB 9000-PDP 12 in electron impact mode, a Finnigan 1015-PDP 8/1 in chemical ionization mode, and an atmospheric pressure ionization mass spectrometer. Sensitivity of detection was in the nanogram to picogram range.

scholarly journals Studies of the mechanism of the cluster formation in a thermally sampling atmospheric pressure ionization mass spectrometer

2014 ◽  
Vol 85 (1) ◽  
pp. 014102 ◽  
Author(s):  
Sascha Albrecht ◽  
Sebastian Klopotowski ◽  
Valerie Derpmann ◽  
Sonja Klee ◽  
Klaus J. Brockmann ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
Atmospheric Pressure ◽  
Cluster Formation ◽  
Ionization Mass ◽  
Atmospheric Pressure Ionization
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