Comparison of sampling techniques for combined supercritical fluid chromatography and Fourier-transform infrared spectrometry with mobile phase elimination

1989 ◽  
Vol 61 (19) ◽  
pp. 2212-2218 ◽  
Author(s):  
Roger. Fuoco ◽  
Stephen L. Pentoney ◽  
Peter R. Griffiths
Keyword(s):  
Fourier Transform ◽  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Mobile Phase ◽  
Fourier Transform Infrared ◽  
Infrared Spectrometry ◽  
Sampling Techniques ◽  
Fourier Transform Infrared Spectrometry ◽  
Phase Elimination

Separation and Identification of Sulfonamide Drugs via SFC/FT-IR Mobile-Phase Elimination Interface

1997 ◽  
Vol 51 (12) ◽  
pp. 1791-1795 ◽  
Author(s):  
Mehdi Ashraf-Khorassani ◽  
Michael T. Combs ◽  
Larry T. Taylor ◽  
Jim Willis ◽  
Xiaojun Liu ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Fourier Transform ◽  
Supercritical Fluid ◽  
Mobile Phase ◽  
Packed Column ◽  
Infrared Spectrometry ◽  
Fourier Transform Infrared Spectrometry ◽  
Phase Gradient ◽  
Ft Ir ◽  
Phase Elimination

Packed-column supercritical fluid chromatography with a mobile-phase gradient of carbon dioxide and methanol has been performed on a mixture of eight sulfonamides. The analytes were detected and identified with Fourier transform infrared spectrometry. A commercial mobile-phase elimination interface (LC-Transform®) was employed. A fixed-integral restrictor afforded the decompression zone between the column and germanium disk where the analytes were deposited. Excellent-quality infrared spectra were obtained for all eight separated analytes.

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