Direct analysis of high-performance thin-layer chromatography spots of nucleic purine derivatives by surface-enhanced Raman scattering spectrometry

1987 ◽  
Vol 59 (3) ◽  
pp. 525-527 ◽  
Author(s):  
Jean Marie L. Sequaris ◽  
Eckhard. Koglin
1993 ◽  
Vol 47 (9) ◽  
pp. 1464-1470 ◽  
Author(s):  
W. G. Fateley ◽  
R. M. Hammaker ◽  
J. V. Paukstelis ◽  
S. L. Wright ◽  
E. A. Orr ◽  
...  

Spatial imaging of thin-layer chromatography plates using laser-induced fluorescence and surface-enhanced Raman scattering has been accomplished with a stationary two-dimensional Hadamard encoding mask. Detection of three nanograms of pararosaniline hydrochloride on a thin-layer chromatography plate was made possible by means of the surface-enhanced Raman phenomenon. The imaging capabilities of the stationary two-dimensional Hadamard encoding mask coupled with the depth profiling ability of photoacoustic detection allows for the three-dimensional photoacoustic imaging of a multiple analyte sample.


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