Laser videofluorometer system for real-time characterization of high-performance liquid chromatographic eluate

1986 ◽  
Vol 58 (13) ◽  
pp. 2831-2839 ◽  
Author(s):  
D. Bruce. Skoropinski ◽  
James B. Callis ◽  
J. D. Sheldon. Danielson ◽  
Gary D. Christian
Keyword(s):  
Real Time ◽  
High Performance ◽  
High Performance Liquid Chromatographic ◽  
Liquid Chromatographic

Microscopic characterization of high-performance liquid chromatographic packing materials

1991 ◽  
Vol 544 ◽  
pp. 319-344 ◽  
Author(s):  
Nobuo Tanaka ◽  
Kazuhiro Kimata ◽  
Takeo Araki ◽  
Hajime Tsuchiya ◽  
Katsushi Hashizume
Keyword(s):  
High Performance ◽  
High Performance Liquid Chromatographic ◽  
Packing Materials ◽  
Liquid Chromatographic

High-performance liquid chromatographic characterization of monofluorophosphate, difluorophosphate and hexafluorophosphate

1994 ◽  
Vol 664 (1) ◽  
pp. 111-116 ◽  
Author(s):  
Norimasa Yoza ◽  
Sachiko Nakashima ◽  
Nobuyuki Ueda ◽  
Tohru Miyajima ◽  
Terumasa Nakamura ◽  
...  
Keyword(s):  
High Performance ◽  
High Performance Liquid Chromatographic ◽  
Chromatographic Characterization ◽  
Liquid Chromatographic

scholarly journals Preparation and Characterization of Resveratrol Loaded Pectin/Alginate Blend Gastro-Resistant Microparticles

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1886 ◽  
Author(s):  
Oihane Gartziandia ◽  
Arrate Lasa ◽  
Jose Pedraz ◽  
Jonatan Miranda ◽  
Maria Portillo ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
High Performance ◽  
High Performance Liquid Chromatographic ◽  
Hplc Method ◽  
European Pharmacopoeia ◽  
Oral Ingestion ◽  
Obesity Therapy ◽  
Encapsulation Process ◽  
Liquid Chromatographic

Background: The use of resveratrol as a dietary supplement is limited because it is easily oxidized and, after oral ingestion, it is metabolized into enterocytes and hepatocytes. Thus, new formulations are needed in order to improve its oral bioavailability. Objective: The objective of this study was to develop and characterize a gastro-resistant formulation of resveratrol for oral administration as a dietary supplement. Method: Resveratrol was encapsulated in Eudragit-coated pectin-alginate microparticles. Results: The microparticle size was about 1450 µm, with an encapsulation efficiency of 41.72% ± 1.92%. The dissolution assay conducted, as specified in the European Pharmacopoeia for delayed-release dosage forms, revealed that our microparticles were gastro-resistant, because the resveratrol percentage released from microparticles in acid medium was less than 10%. In addition, the high-performance liquid chromatographic (HPLC) method developed for resveratrol content quantification in the microparticles was validated according to International Council for Harmonisation (ICH) Q2 (R1) guidelines. Finally, the biological activity of resveratrol was investigated in 3T3-L1 mature adipocytes, concluding that the encapsulation process does not affect the activity of resveratrol. Conclusion: In summary, the gastro-resistant microparticles developed could represent a suitable method of including resveratrol in dietary supplements and in functional foods used in obesity therapy.

Sign in / Sign up

Export Citation Format

Share Document