Real-Time Measurement Capabilities Using Aerosol Time-of-Flight Mass Spectrometry

1994 ◽  
Vol 66 (20) ◽  
pp. 3540-3542 ◽  
Author(s):  
T. Nordmeyer ◽  
K. A. Prather
Keyword(s):  
Mass Spectrometry ◽  
Real Time ◽  
Time Of Flight ◽  
Time Measurement ◽  
Flight Mass Spectrometry ◽  
Real Time Measurement ◽  
Measurement Capabilities

scholarly journals Thermal Properties, Isothermal Decomposition by Direct Analysis in Real-Time-Of-Flight Mass Spectrometry and Non Isothermal Crystallization Kinetics of Poly(Ethylene-Co-Vinyl Alcohol)/Poly(ε-Caprolactone) Blend

Crystals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 292
Author(s):  
Abdulaziz Ali Alghamdi ◽  
Hussain Alattas ◽  
Waseem Sharaf Saeed ◽  
Abdel-Basit Al-Odayni ◽  
Ahmed Yacine Badjah Hadj Ahmed ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Real Time ◽  
Crystallization Kinetics ◽  
Isothermal Crystallization ◽  
Vinyl Alcohol ◽  
Time Of Flight ◽  
Direct Analysis ◽  
Isothermal Crystallization Kinetics ◽  
Flight Mass Spectrometry ◽  
Poly Ethylene

A series of poly(ethylene-co-vinyl alcohol)/poly(ε-caprolactone) blends with different compositions were prepared using solvent casting. The miscibility of this pair of polymers was investigated using differential scanning calorimetry (DSC), and proved by a negative Flory interaction parameter value calculated from the Nishi–Wang equation. The miscibility of this blend was also confirmed by scanning electronic microscopy (SEM). The thermal behaviors of the obtained materials were investigated by DSC, thermogravimetric analysis, and direct analysis in real-time–time-of-flight mass spectrometry and the results obtained were very relevant. Furthermore, the crystalline properties of the obtained materials were studied by DSC and X-ray diffraction where the Ozawa approach was adopted to investigate the non-isothermal crystallization kinetics. The results obtained revealed that this approach described the crystallization process well.

Ionization characteristics of glycosides by direct analysis in real time quadrupole-time of flight mass spectrometry

2017 ◽  
Vol 41 (3) ◽  
pp. 1103-1109 ◽  
Author(s):  
Hongmei Yang ◽  
Ge Gao ◽  
Yihan Wang ◽  
Jinrong Liu ◽  
Zongjun Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Real Time ◽  
Time Of Flight ◽  
Direct Analysis ◽  
Molecular Ion ◽  
Ion Formation ◽  
Flight Mass Spectrometry

Glycosides were ionized via various different reactions including (de)protonation, molecular ion formation, ISD fragmentation, and the formation of adducts.

Screening of psychoactive components in fresh khat using direct analysis in real time-time of flight-mass spectrometry

2018 ◽  
Vol 1 (3) ◽  
pp. 45 ◽  
Author(s):  
AbdulrhmanM Dhabbah ◽  
AYacine Badjah-Hadj-Ahmed ◽  
AliI Alawi ◽  
WaleedAbdulaziz Al Angari ◽  
BaselF Alrayes
Keyword(s):  
Mass Spectrometry ◽  
Real Time ◽  
Time Of Flight ◽  
Direct Analysis ◽  
Flight Mass Spectrometry

Emerging Synthetic Cannabinoids: Development and Validation of a Novel Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry Assay for Real-Time Detection

2019 ◽  
Vol 44 (3) ◽  
pp. 207-217 ◽  
Author(s):  
Alex J Krotulski ◽  
Amanda L A Mohr ◽  
Barry K Logan
Keyword(s):  
United States ◽  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Real Time ◽  
Synthetic Cannabinoids ◽  
Time Of Flight ◽  
Forensic Toxicology ◽  
The United States ◽  
Synthetic Cannabinoid ◽  
Flight Mass Spectrometry

Abstract Synthetic cannabinoids pose significant threats to public health and safety, as their implications in overdose and adverse events continue to arise in United States and around the world. Synthetic cannabinoids have seen several generations of chemically diverse structural elements, impacting potency and effects. These factors create new analytical challenges for forensic laboratories. This report describes an efficient liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) assay for the identification of synthetic cannabinoid parent compounds and metabolites, including real-time identification of emergent compounds, using a SCIEX TripleTOF® 5600+ with non-targeted SWATH® acquisition. Method validation evaluated precision/accuracy, limits of detection, interferences, processed sample stability and carryover, for which 19 parent compounds and 19 metabolites were tested. To demonstrate feasibility, de-identified blood sample extracts were acquired from a large forensic toxicology laboratory and analyzed using the validated LC-QTOF-MS assay. In mid-2018, 200 blood extracts were analyzed, demonstrating a 19% positivity rate with > 94% agreement rate with original testing. In addition, three newly discovered synthetic cannabinoids were identified, including 5F-MDMB-PICA, 4-cyano CUMYL-BUTINACA and 5F-EDMB-PINACA. These synthetic cannabinoids were previously unreported in forensic toxicology casework in the United States. 5F-MDMB-PICA has become the most prevalent synthetic cannabinoid in United States, as of early 2019. These results demonstrate the effectiveness of this assay and workflow in the identification and characterization of synthetic cannabinoids, as well as the usefulness of sample-mining using non-targeted mass acquisition by LC-QTOF-MS for the discovery of NPS. High resolution mass spectrometry should be considered when developing new or novel assays for synthetic cannabinoids.

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