Rapid method for the determination of phase behavior of fluid mixtures employed in supercritical fluid experiments

1993 ◽  
Vol 65 (10) ◽  
pp. 1493-1495 ◽  
Author(s):  
Steven H. Page ◽  
Hao. Yun ◽  
Milton L. Lee ◽  
Steven R. Goates
Keyword(s):  
Phase Behavior ◽  
Rapid Method ◽  
Supercritical Fluid ◽  
Fluid Mixtures

scholarly journals Solubilities in supercritical fluids

2005 ◽  
Vol 77 (3) ◽  
pp. 513-530 ◽  
Author(s):  
Dana E. Knox
Keyword(s):  
Phase Behavior ◽  
Supercritical Fluid ◽  
Supercritical Fluids ◽  
Food Processing ◽  
Significant Variation ◽  
Powder Processing ◽  
Equations Of State ◽  
Pollution Prevention ◽  
Controlled Drug Delivery

Solubilities in supercritical fluids are of great importance in a wide variety of applications. These applications include: production of controlled drug delivery systems, powder processing, pollution prevention and remediation, methods for spraying paints and coatings, precipitation/crystallization processes, bioseparations, and food processing. Examples of some of these applications will be given.Supercritical fluid processes make use of the significant variation of solubility with pressure when the solvent is a supercritical fluid. This permits the accomplishment of many processes that would be otherwise very difficult to achieve. To fully understand the benefits of such processes, one must understand the phase behavior of such systems. The types of phase behavior that can be observed will be discussed, along with the ways that this behavior can be used to modify solubilities in such fluids.There have been many methods proposed for the experimental determination of solubilities in supercritical fluids. These will be reviewed in general, and recommendations for preferred methods given.Solubilities in supercritical fluids can be correlated and predicted by making use of thermodynamic calculations involving equations of state, as well as by other methods. The various methods will be reviewed, and recommendations given for various applications.

Supercritical fluid mixtures: prediction of the phase behavior

1985 ◽  
Vol 89 (12) ◽  
pp. 2671-2675 ◽  
Author(s):  
J. M. Wong ◽  
R. S. Pearlman ◽  
K. P. Johnston
Keyword(s):  
Phase Behavior ◽  
Supercritical Fluid ◽  
Fluid Mixtures

A Rapid Method for Determination of Buprenorphine and Norbuprenorphine in Urine by UPLC-MS/MS

2020 ◽  
Vol 16 ◽  
Author(s):  
Aykut Kul ◽  
Murat Ozdemir ◽  
Selma Ozilhan ◽  
Olcay Sagirli
Keyword(s):  
Forensic Science ◽  
Rapid Method ◽  
Proficiency Testing ◽  
Mass Spectrometer ◽  
Illicit Market ◽  
Analysis Methods ◽  
Accuracy And Precision ◽  
Lower Limits

Background: Buprenorphine is quite common in the illicit market. Buprenorphine-containing drugs abuse is frequently encountered in patients. The analysis methods used to determine the abuse of buprenorphine and norbuprenorphine are important for forensic science. Buprenorphine is metabolized to norbuprenorphine by the liver. Objective: Therefore, the determination of buprenorphine and norbuprenorphine in urine is one of the methods to determine the abuse of buprenorphine. Methods: In this study, we have developed a precise, simple, and rapid ultra-performance liquid chromatographytandem mass spectrometer method for the determination of buprenorphine and norbuprenorphine simultaneously. Results: The developed method was validated in terms of selectivity and linearity, which was in the range of 9–1800 ng/mL for both buprenorphine and norbuprenorphine. The intra-assay and inter-assay accuracy and precision were found within acceptable limits of the EMA guideline. Lower limits of quantitation were 9 ng/mL for both buprenorphine and norbuprenorphine. Conclusion: The developed method was successfully applied for the determination of both analytes in the proficiency testing samples.

Sign in / Sign up

Export Citation Format

Share Document