scholarly journals Switched-at-Birth Twins in the Canary Islands: Revisited / Research Reports: Parkinson's Disease Discordance, Assisted Reproductive Technology and Neonatal Surgery, Double Embryo Transfer in a Cynomolgus Monkey, Mathematical Analysis of a Twin Convention Conundrum / Media Highlights: Twin Inventors, Basketball Duo, Two Comedians, Paired Designers, Two Musicians, Two Comedians, Twins’ Birth Interval

2013 ◽  
Vol 16 (4) ◽  
pp. 916-921 ◽  
Author(s):  
Nancy L. Segal
Keyword(s):  
Parkinson’S Disease ◽  
New York ◽  
Parkinson's Disease ◽  
Embryo Transfer ◽  
Cynomolgus Monkey ◽  
Human Genetics ◽  
Neonatal Surgery ◽  
Twin Research ◽  
True Story ◽  
Double Embryo Transfer

Switched-at-birth twins from Las Palmas, Gran Canaria in Spain drew international attention in May 2008 following news reports of their unexpected reunion. I visited Las Palmas in September 2009 to research this case and presented the findings in Segal and Blandón-Gitlin (Twin Research and Human Genetics, Vol. 13, 2010, pp. 115–119) and in a book, Someone Else's Twin: The True Story of Babies Switched at Birth (Segal, Prometheus Books, Amherst, New York, 2011). I traveled again to Las Palmas in November 2012 to meet with the twins, their families, and their attorneys and have updated my findings in this article. Next, new twin research on Parkinson's disease discordance, neonatal surgery, double embryo transfer in a cynomolgus monkey, and a convention conundrum are presented. Media highlights concerning twin inventors, basketball players, rappers, designers, musicians, and birth intervals are also summarized.

scholarly journals Gait Study of Parkinson’s Disease Subjects Using Haptic Cues with A Motorized Walker

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3549 ◽  
Author(s):  
Minhua Zhang ◽  
N. Artan ◽  
Huanying Gu ◽  
Ziqian Dong ◽  
Lyudmila Burina Ganatra ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
New York ◽  
Parkinson's Disease ◽  
Gait Cycle ◽  
Asymmetry Index ◽  
Gait Symmetry ◽  
Double Support ◽  
College Of Osteopathic Medicine ◽  
Institute Of Technology ◽  
Gait Abnormalities

Gait abnormalities are one of the distinguishing symptoms of patients with Parkinson’s disease (PD) that contribute to fall risk. Our study compares the gait parameters of people with PD when they walk through a predefined course under different haptic speed cue conditions (1) without assistance, (2) pushing a conventional rolling walker, and (3) holding onto a self-navigating motorized walker under different speed cues. Six people with PD were recruited at the New York Institute of Technology College of Osteopathic Medicine to participate in this study. Spatial posture and gait data of the test subjects were collected via a VICON motion capture system. We developed a framework to process and extract gait features and applied statistical analysis on these features to examine the significance of the findings. The results showed that the motorized walker providing a robust haptic cue significantly improved gait symmetry of PD subjects. Specifically, the asymmetry index of the gait cycle time was reduced from 6.7% when walking without assistance to 0.56% and below when using a walker. Furthermore, the double support time of a gait cycle was reduced by 4.88% compared to walking without assistance.

scholarly journals Solvent Exposure and Parkinson's Disease: Co-Twin Control Study/ Twin Research Reports / Human Interest Stories

2012 ◽  
Vol 15 (3) ◽  
pp. 468-471
Author(s):  
Nancy L. Segal
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Risk ◽  
Prenatal Development ◽  
Population Based ◽  
Solvent Exposure ◽  
Population Based Study ◽  
Twin Research ◽  
Monozygous Twin ◽  
Control Designs

Naturally occurring co-twin control designs can assess associations between environmental hazards and disease risk because the genotypes of monozygous twins are the same. The first population-based study to explore links between solvent exposure and Parkinson's disease used 49 discordant monozygous twin pairs, as well as a comparison group of 50 discordant dizygous twin pairs. The methods, findings and implications from this important study are reviewed. Reviews of twin research concerning gender identity disorder, prenatal development and the VATER syndrome follow. A sampling of engaging and informative twin-related news items is also presented.

scholarly journals Co-Twin Control Studies: Natural Events, Experimental Interventions and Rare Happenings/Twin Research: Cancer Risk in Overweight Twins; Prognosis After Fetal Loss of One Twin; Twin Concordance for Parkinson’s Disease; Neuroanatomy of Musically Discordant MZ Twins/News Articles: Twin Birth with Two Wombs; Twins’ Prenatal Interactions; Switched-at-Birth Twins; Fetus-in-Fetu; Unsolved Paternity

2019 ◽  
Vol 22 (4) ◽  
pp. 272-276
Author(s):  
Nancy L. Segal
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cancer Risk ◽  
Research Design ◽  
Fetal Loss ◽  
Fetus In Fetu ◽  
Twin Research ◽  
Twin Birth ◽  
Physical Risk ◽  
Mz Twins

AbstractCo-twin control is a well-known methodological twin research design, but its variations and complexities are less well known. Various issues and illustrations are presented with reference to studies involving natural events, experimental interventions and rare happenings that underlie monozygotic (MZ) twins’ environmental differences. This discussion is followed by summaries of recent twin research pertaining to cancer risk in overweight twins, the physical risk to surviving twins after fetal loss of a co-twin, a 20-year update of twin concordance for Parkinson’s disease, and neuroanatomical differences in musically discordant MZ twin pairs. Several twin-related items that have attracted attention in the news are also summarized.

Irving S. Cooper (1922–1985): a pioneer in functional neurosurgery

1998 ◽  
Vol 89 (5) ◽  
pp. 865-873 ◽  
Author(s):  
Kaushik Das ◽  
Deborah L. Benzil ◽  
Richard L. Rovit ◽  
Raj Murali ◽  
William T. Couldwell
Keyword(s):  
Parkinson’S Disease ◽  
New York ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Movement Disorders ◽  
Surgical Techniques ◽  
Primary Control ◽  
New York University ◽  
Functional Neurosurgery ◽  
Content Type

✓ Irving S. Cooper (1922–1985), the son of a salesman, worked his way through high school, college, and medical school to become one of the pioneers in functional neurosurgery. He developed several novel techniques for the surgical management of Parkinson's disease and other crippling movement disorders. A keen interest in the physiology of movement disorders was kindled by his doctoral research and continued during his neurosurgical training. He began to apply this knowledge to surgical practice in 1952 when he began his faculty career as Assistant Professor of Surgery at New York University. At the time, surgical treatment of parkinsonian tremor focused on various techniques used to interrupt the pyramidal tract. During a subtemporal approach for a cerebral pedunculotomy, he inadvertently injured and, subsequently, was forced to occlude the anterior choroidal artery. Much to Cooper's surprise, following emergence from anesthesia the patient's tremor and rigidity were abolished without any residual hemiparesis. This serendipitous observation, together with Meyer's earlier work on the role of the basal ganglia in motor control, helped focus surgical efforts on targets within the basal ganglia and, subsequently, within the thalamus to alleviate the movement disorders associated with Parkinson's disease. While at New York University, Cooper developed chemopallidectomy and, later at St. Barnabas Hospital in the Bronx (1954–1977), he used cryothalamectomy as a surgical technique for primary control of tremor in patients with Parkinson's disease. Cooper authored many original papers on surgical techniques and several textbooks on the lives of patients afflicted with Parkinson's disease and other crippling movement disorders. Although considered controversial, this fascinating and complex neurosurgeon made significant contributions to this field.

scholarly journals Association between exposure to PM2.5 components and disease aggravation in Parkinson’s disease: an analysis in New York State

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Yanelli Nunez ◽  
Amelia K. Boehme ◽  
Maggie Li ◽  
Jeff Goldsmith ◽  
Marc G. Weisskopf ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
New York ◽  
Parkinson's Disease ◽  
New York State ◽  
York State
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