Event-Based Prospective Memory in Newly Diagnosed, Drug-Naive Parkinson's Disease Patients

2011 ◽  
Vol 17 (6) ◽  
pp. 1158-1162 ◽  
Author(s):  
Cristina Pagni ◽  
Daniela Frosini ◽  
Roberto Ceravolo ◽  
Giulia Giunti ◽  
Elisa Unti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Memory ◽  
De Novo ◽  
Memory Task ◽  
Newly Diagnosed ◽  
Neuropsychological Battery ◽  
Effect Of Therapy ◽  
Correct Execution ◽  
Event Based

AbstractThe present study investigated memory for intention in individuals with Parkinson's disease (PD) who were newly diagnosed and not yet treated to avoid the effect of therapy as a potential confounding variable. A comprehensive neuropsychological battery and an event-based prospective memory task were administered to 41 subjects with de novo PD and 40 control subjects. Separate scores were computed for correct execution of intended action (prospective component) and recall of intention (retrospective component). PD patients performed marginally worse (p = .053) than controls on the prospective component of the task. On the other hand, the performance of the two groups was comparable for the retrospective component. Neuropsychological findings revealed lower performance of the PD group in episodic memory and in some measures of executive functions. These results suggested a subtle prospective memory dysfunction present at the initial stage of PD, which may be related to disruption of fronto-striatal circuitry. (JINS, 2011, 17, 1158–1162)

scholarly journals Levodopa improves time-based prospective memory in Parkinson's disease

2008 ◽  
Vol 14 (4) ◽  
pp. 601-610 ◽  
Author(s):  
ALBERTO COSTA ◽  
ANTONELLA PEPPE ◽  
LIVIA BRUSA ◽  
CARLO CALTAGIRONE ◽  
ILARIA GATTO ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Memory ◽  
Memory Task ◽  
Correct Recall ◽  
Memory Deficits ◽  
Healthy Controls ◽  
Prospective Memory Task ◽  
Dopamine Depletion ◽  
Correct Execution

The present study was aimed at investigating the effect of acute levodopa administration on the performance of a group of individuals with Parkinson's disease (PD) on a time-based prospective memory task. Twenty PD patients and 15 healthy controls were administered a task that required executing three actions after 10 min had elapsed in three consecutive trials. Scores were computed for correct recall of the intention to perform the actions and for correct execution of the actions. PD participants were evaluated after a 12-hr drug wash-out in two conditions: (1) after levodopa administration (“on”); (2) without drug administration (“off”). In the “on” condition, PD patients were significantly more accurate in retrieving the intention to perform the actions than in the “off” condition and their performance was actually comparable to that of healthy controls. The increased accuracy in complying with the prospective memory task following levodopa medication supports the idea that dopamine depletion plays a role in the prospective memory deficits observed in PD patients. (JINS, 2008, 14, 601–610.)

Decreased event-based prospective memory functioning in individuals with Parkinson's disease

2013 ◽  
Vol 7 (2) ◽  
pp. 153-163 ◽  
Author(s):  
Alberto Costa ◽  
Antonella Peppe ◽  
Carlo Caltagirone ◽  
Giovanni A. Carlesimo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Memory ◽  
Memory Functioning ◽  
Event Based

Prospective Memory in Parkinson's Disease: A Meta-analysis

2013 ◽  
Vol 19 (10) ◽  
pp. 1109-1118 ◽  
Author(s):  
Siddharth Ramanan ◽  
Devvarta Kumar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Memory ◽  
Task Complexity ◽  
Meta Analysis ◽  
Mediating Role ◽  
Intended Action ◽  
Analytic Review ◽  
Event Based

AbstractProspective memory (PM) refers to the ability to remember to carry out an intended action in the future and it is pervasive in our daily living. A failure to execute an intended action (e.g., take medication) at the appropriate juncture in future (e.g., after dinner) can negatively affect our daily functioning and at times, may have devastating effects (e.g., forgetting to turn off the gas stove before leaving the house). Patients with Parkinson's disease (PD) exhibit widespread cognitive deficits including deficits in PM. The present study provides a meta-analytic review of PM in PD. Results across nine studies indicated time and event-based PM to be similarly impaired in PD, with time-based PM compromised to a slightly larger extent (Hedges’ g = −0.71) as compared to event-based PM (Hedges’ g = −0.55). The impairment in PM is more likely due to failure in self-initiated retrieval of intention to be executed, rather than forgetting the content of the intention itself. Furthermore, factors such as intervening task complexity and the mediating role of other executive functions have also been proposed to be responsible for impaired PM in PD. (JINS, 2013, 19, 1–10)

scholarly journals A differential deficit in time- versus event-based prospective memory in Parkinson's disease.

2011 ◽  
Vol 25 (2) ◽  
pp. 201-209 ◽  
Author(s):  
Sarah A. Raskin ◽  
Steven Paul Woods ◽  
Amelia J. Poquette ◽  
April B. McTaggart ◽  
Jim Sethna ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Memory ◽  
Differential Deficit ◽  
Event Based

scholarly journals Event-based prospective memory in patients with Parkinson’s disease: the effect of emotional valence

2015 ◽  
Vol 9 ◽  
Author(s):  
G. Mioni ◽  
L. Meligrana ◽  
P. G. Rendell ◽  
L. Bartolomei ◽  
F. Perini ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Memory ◽  
Emotional Valence ◽  
Event Based

Association of the Non-Motor Burden with Patterns of Striatal Dopamine Loss in de novo Parkinson’s Disease

2020 ◽  
Vol 10 (4) ◽  
pp. 1541-1549
Author(s):  
Seok Jong Chung ◽  
Sangwon Lee ◽  
Han Soo Yoo ◽  
Yang Hyun Lee ◽  
Hye Sun Lee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
De Novo ◽  
Early Stage ◽  
Striatal Dopamine ◽  
Motor Deficits ◽  
Dopamine Depletion ◽  
Severe Motor ◽  
Severe Group ◽  
Striatal Dopamine Depletion

Background: Striatal dopamine deficits play a key role in the pathogenesis of Parkinson’s disease (PD), and several non-motor symptoms (NMSs) have a dopaminergic component. Objective: To investigate the association between early NMS burden and the patterns of striatal dopamine depletion in patients with de novo PD. Methods: We consecutively recruited 255 patients with drug-naïve early-stage PD who underwent 18F-FP-CIT PET scans. The NMS burden of each patient was assessed using the NMS Questionnaire (NMSQuest), and patients were divided into the mild NMS burden (PDNMS-mild) (NMSQuest score <6; n = 91) and severe NMS burden groups (PDNMS-severe) (NMSQuest score >9; n = 90). We compared the striatal dopamine transporter (DAT) activity between the groups. Results: Patients in the PDNMS-severe group had more severe parkinsonian motor signs than those in the PDNMS-mild group, despite comparable DAT activity in the posterior putamen. DAT activity was more severely depleted in the PDNMS-severe group in the caudate and anterior putamen compared to that in the PDMNS-mild group. The inter-sub-regional ratio of the associative/limbic striatum to the sensorimotor striatum was lower in the PDNMS-severe group, although this value itself lacked fair accuracy for distinguishing between the patients with different NMS burdens. Conclusion: This study demonstrated that PD patients with severe NMS burden exhibited severe motor deficits and relatively diffuse dopamine depletion throughout the striatum. These findings suggest that the level of NMS burden could be associated with distinct patterns of striatal dopamine depletion, which could possibly indicate the overall pathological burden in PD.

Sign in / Sign up

Export Citation Format

Share Document