Toxocariasis associated with chronic cough in childhood: a longitudinal study in Hungary

2008 ◽  
Vol 82 (4) ◽  
pp. 357-363 ◽  
Author(s):  
O. Bede ◽  
Z. Szénási ◽  
J. Danka ◽  
K. Gyurkovits ◽  
D. Nagy
Keyword(s):  
Chronic Cough ◽  
Toxocara Canis ◽  
Inhaled Corticosteroid ◽  
Cough Variant Asthma ◽  
Eosinophilic Bronchitis ◽  
Eosinophil Cell ◽  
Airway Symptoms ◽  
Intractable Problem ◽  
Positive Effect

AbstractChronic cough lasting 8 weeks or more often seems to be an intractable problem in childhood. Toxocara infection is associated with an increased prevalence of airway symptoms and may be the possible aetiological agent of chronic cough. Of 425 children aged 2–17 years with chronic cough who were investigated for toxocariasis and the distribution of bronchial asthma (BA), cough variant asthma (CVA) and non-asthmatic eosinophilic bronchitis (NAEB), 136 (32%) were seropositive for Toxocara canis antigens. Ninety-three of the 136 were adequately assessed, diagnosed and followed up during 1 year. BA was diagnosed in 40%, CVA in 27% and NAEB in 33% of the children. The eosinophil cell count, serum T. canis IgG levels and symptoms are predictors of the improvement or the decline of the condition. Presuming the aetiopathogenetic role of T. canis in the inflammatory process of chronic cough, we treated the children not only with inhaled corticosteroid (ICS), but also with a 1-week course of anthelminthics. We could significantly decrease the dose of ICS in 23 (62%) of the 37 with BA. The administration of anthelminthics and the avoidance of sensitizers were sufficient for those with NAEB; none needed ICS. ICS therapy could be stopped 2–3 months later in 17 (68%) of the 25 with CVA. We found that 8 of the 25 with CVA (32%) presented asthmatic symptoms at the end of the 1-year period. In Hungary, T. canis may be a potential sensitizer for chronic cough in seropositive children. Deworming therapy will then alleviate the airway symptoms without exacerbation in patients with BA, and have a positive effect on those with NAEB and the majority of those with CVA.

European Respiratory Society guidelines on the diagnosis and treatment of chronic cough in adults and children

2021 ◽  
Vol 31 (4) ◽  
pp. 418-438
Author(s):  
A. H. Morice ◽  
E. Millqvist ◽  
K. Bieksiene ◽  
S. S. Birring ◽  
P. Dicpinigaitis ◽  
...  
Keyword(s):  
Chronic Cough ◽  
Acid Reflux ◽  
Drug Dose ◽  
Diagnosis And Treatment ◽  
European Respiratory Society ◽  
Cough Variant Asthma ◽  
Eosinophilic Bronchitis ◽  
Highly Effective ◽  
Adults And Children ◽  
External Stimuli

These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli such a cold air, perfumes, smoke and bleach. Thus, adults with chronic cough now have a firm physical explanation for their symptoms based on vagal afferent hypersensitivity. Different treatable traits exist with cough variant asthma (CVA)/eosinophilic bronchitis responding to anti-inflammatory treatment and non-acid reflux being treated with promotility agents rather the anti-acid drugs. An alternative antitussive strategy is to reduce hypersensitivity by neuromodulation. Low-dose morphine is highly effective in a subset of patients with cough resistant to other treatments. Gabapentin and pregabalin are also advocated, but in clinical experience they are limited by adverse events. Perhaps the most promising future developments in pharmacotherapy are drugs which tackle neuronal hypersensitivity by blocking excitability of afferent nerves by inhibiting targets such as the ATP receptor (P2X3). Finally, cough suppression therapy when performed by competent practitioners can be highly effective. Children are not small adults and a pursuit of an underlying cause for cough is advocated. Thus, in toddlers, inhalation of a foreign body is common. Persistent bacterial bronchitis is a common and previously unrecognised cause of wet cough in children. Antibiotics (drug, dose and duration need to be determined) can be curative. A paediatric-specific algorithm should be used.

scholarly journals Blood eosinophils as a predictor of treatment response in adults with difficult-to-treat chronic cough

2021 ◽  
pp. 00432-2021
Author(s):  
Aleksandra Rybka-Fraczek ◽  
Marta Dabrowska ◽  
Elzbieta M. Grabczak ◽  
Katarzyna Bialek-Gosk ◽  
Karolina Klimowicz ◽  
...  
Keyword(s):  
Treatment Response ◽  
Chronic Cough ◽  
Blood Eosinophil ◽  
Blood Eosinophil Count ◽  
Eosinophilic Bronchitis ◽  
Leicester Cough Questionnaire ◽  
Normal Chest ◽  
Chest X Ray ◽  
Blood Eosinophils

There is lack of evidence on the role of blood eosinophil count (BEC) as a predictor of treatment response in patients with chronic cough (CC). The study aimed to evaluate BEC as a predictor of treatment response in all non-smoking adults with CC and normal chest X-ray referred to cough clinic and in subgroup of patients with CC due to asthma or NAEB (non-asthmatic eosinophilic bronchitis).This prospective cohort study included 142 consecutive, non-smoking patients referred to our cough centre due to CC. The management of CC was performed according to the current recommendations. At least a 30 mm decrease of 100-mm visual analogue scale in cough severity and a 1.3 points improvement in Leicester Cough Questionnaire were classified as a good therapeutic response.There was a predominance of females (72.5%), median age 57.5 years with long-lasting, severe cough (median cough duration 60 months, severity 55/100 mm). Asthma, NAEB were diagnosed in 47.2% and 4.9% of patients, respectively. After 12–16 weeks of therapy, a good response to CC treatment was found in 31.0% of all patients. A weak positive correlation was demonstrated between reduction in cough severity and BEC (r=0.28, p<0.001). AUC for all patients with CC was 0.62 with the optimal BEC cut-off for prediction of treatment response set at 237 cells·µL−1 and for patients with CC due to asthma/NAEB was 0.68 (95% CI 0.55–0.81) with the cut-off at 150 cells·µL−1.BEC is a poor predictor of treatment response in adults with CC treated in the cough centre.

scholarly journals ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

2019 ◽  
Vol 55 (1) ◽  
pp. 1901136 ◽  
Author(s):  
Alyn H. Morice ◽  
Eva Millqvist ◽  
Kristina Bieksiene ◽  
Surinder S. Birring ◽  
Peter Dicpinigaitis ◽  
...  
Keyword(s):  
Chronic Cough ◽  
Acid Reflux ◽  
Drug Dose ◽  
Diagnosis And Treatment ◽  
Cough Variant Asthma ◽  
Eosinophilic Bronchitis ◽  
Highly Effective ◽  
Adults And Children ◽  
Wet Cough ◽  
External Stimuli

These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli such a cold air, perfumes, smoke and bleach. Thus, adults with chronic cough now have a firm physical explanation for their symptoms based on vagal afferent hypersensitivity. Different treatable traits exist with cough variant asthma (CVA)/eosinophilic bronchitis responding to anti-inflammatory treatment and non-acid reflux being treated with promotility agents rather the anti-acid drugs. An alternative antitussive strategy is to reduce hypersensitivity by neuromodulation. Low-dose morphine is highly effective in a subset of patients with cough resistant to other treatments. Gabapentin and pregabalin are also advocated, but in clinical experience they are limited by adverse events. Perhaps the most promising future developments in pharmacotherapy are drugs which tackle neuronal hypersensitivity by blocking excitability of afferent nerves by inhibiting targets such as the ATP receptor (P2X3). Finally, cough suppression therapy when performed by competent practitioners can be highly effective. Children are not small adults and a pursuit of an underlying cause for cough is advocated. Thus, in toddlers, inhalation of a foreign body is common. Persistent bacterial bronchitis is a common and previously unrecognised cause of wet cough in children. Antibiotics (drug, dose and duration need to be determined) can be curative. A paediatric-specific algorithm should be used.

The Role of Inhaled Corticosteroid in the Management of Chronic Cough

2006 ◽  
Vol 60 (2) ◽  
pp. 221 ◽  
Author(s):  
Kyung-Hun Lee ◽  
Seung Hun Jang ◽  
Jung-Hwa Lee ◽  
Kwang-Seok Eom ◽  
Joon-Woo Bahn ◽  
...  
Keyword(s):  
Chronic Cough ◽  
Inhaled Corticosteroid

scholarly journals Differential features of chronic cough according to etiology and the simple decision tree for predicting causes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hyeon-Kyoung Koo ◽  
Won Bae ◽  
Ji-Yong Moon ◽  
Hyun Lee ◽  
Jin Woo Kim ◽  
...  
Keyword(s):  
Decision Tree ◽  
Chronic Cough ◽  
Upper Airway ◽  
Significant Feature ◽  
Clinical Prediction Model ◽  
Cough Variant Asthma ◽  
Eosinophilic Bronchitis ◽  
Leicester Cough Questionnaire ◽  
Tree Models ◽  
Cough Assessment

AbstractFinding etiology of chronic cough is an essential part of treatment. Although guidelines include many laboratory tests for diagnosis, these are not possible in many primary care centers. We aimed to identify the characteristics and the differences associated with its cause to develop a clinical prediction model. Adult subjects with chronic cough who completed both Korean version of the Leicester Cough Questionnaire (K-LCQ) and COugh Assessment Test (COAT) were enrolled. Clinical characteristics of each etiology were compared using features included in questionnaires. Decision tree models were built to classify the causes. A total of 246 subjects were included for analysis. Subjects with asthma including cough variant asthma (CVA) suffered from more severe cough in physical and psychological domains. Subjects with eosinophilic bronchitis (EB) presented less severe cough in physical domain. Those with gastro-esophageal reflux disease (GERD) displayed less severe cough in all 3 domains. In logistic regression, voice hoarseness was an independent feature of upper airway cough syndrome (UACS), whereas female sex, tiredness, and hypersensitivity to irritants were predictors of asthma/CVA; less hoarseness was a significant feature of EB, and feeling fed-up and hoarseness were less common characteristics of GERD. The decision tree was built to classify the causes and the accuracy was relatively high for both K-LCQ and COAT, except for UACS. Voice hoarseness, degree of tiredness, hypersensitivity to irritants and feeling fed-up are important features in determining the etiologies. The decision tree may further assists classifying the causes of chronic cough.

Potential Uses of Vinegar as a Medicine and Related in vivo Mechanisms

2016 ◽  
Vol 86 (3-4) ◽  
pp. 127-151 ◽  
Author(s):  
Zeshan Ali ◽  
Zhenbin Wang ◽  
Rai Muhammad Amir ◽  
Shoaib Younas ◽  
Asif Wali ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Review Paper ◽  
Heart Diseases ◽  
Folk Medicine ◽  
Active Role ◽  
Current Review ◽  
Different Types ◽  
Positive Effect

While the use of vinegar to fi ght against infections and other crucial conditions dates back to Hippocrates, recent research has found that vinegar consumption has a positive effect on biomarkers for diabetes, cancer, and heart diseases. Different types of vinegar have been used in the world during different time periods. Vinegar is produced by a fermentation process. Foods with a high content of carbohydrates are a good source of vinegar. Review of the results of different studies performed on vinegar components reveals that the daily use of these components has a healthy impact on the physiological and chemical structure of the human body. During the era of Hippocrates, people used vinegar as a medicine to treat wounds, which means that vinegar is one of the ancient foods used as folk medicine. The purpose of the current review paper is to provide a detailed summary of the outcome of previous studies emphasizing the role of vinegar in treatment of different diseases both in acute and chronic conditions, its in vivo mechanism and the active role of different bacteria.

Peranan Ketua Pengurus dan Manajer Dalam Penyusunan dan Penerapan Laporan Keuangan Berbasis SAK ETAP Pada Koperasi di Kota Palembang

2019 ◽  
Vol 14 (2) ◽  
pp. 119
Author(s):  
Riza Syahputera ◽  
Martha Rianty
Keyword(s):  
Data Analysis ◽  
Sampling Technique ◽  
Financial Statements ◽  
Significant Positive Effect ◽  
Analysis Technique ◽  
Regression Test ◽  
Using Data ◽  
The City ◽  
Positive Effect

AbstractThis study aims to determine the effect of the role of the Chairperson and Cooperative Manager in the preparation and application of Financial Statements based on SAK ETAP in cooperatives in the city of Palembang. This research is a quantitative study using data obtained from questionnaires and measured using a Likert scale. The sampling technique used is purposive sampling. The sample used in this study was the Chairperson of the cooperative and the manager of the cooperative in the city of Palembang. The cooperatives studied were 203 cooperatives. The data analysis technique used is multiple linear regression test. The results showed that the role of cooperative leaders and managers had a significant positive effect on the preparation and application of SAK ETAP-based financial statements.Keywords : chairman, manager, SAK ETAP, cooperative

EMDR as therapy for conditions other than PTSD: a systematic review.

2020 ◽  
Author(s):  
Charles Scelles ◽  
LUIS CARLO BULNES
Keyword(s):  
Mood Disorders ◽  
Obsessive Compulsive ◽  
Treatment As Usual ◽  
Compulsive Disorder ◽  
Adult Personality ◽  
Post Traumatic ◽  
Psychiatric Conditions ◽  
Research Criteria ◽  
Positive Effect

Eye Movement Desensitization and Reprocessing (EMDR) is a treatment for post-traumatic stressdisorder (PTSD). The technique is known to stimulate the capacity to reprocess maladaptive memoriesthat are thought to be central to this pathology. Here we investigate if EMDR therapy can be used in otherconditions than PTSD. We conducted a systematic literature search on PubMed, ScienceDirect, Scopus, and Web of Science. Wesearched for published empirical findings on EMDR, excluding those centred on trauma and PTSD,published up to 2020. The results were classified by psychiatric categories.   Ninety articles met our research criteria. A positive effect was reported in addictions, somatoformdisorders, sexual dysfunction, eating disorder, disorders of adult personality, mood disorders, reaction tosevere stress, anxiety disorders, performance anxiety, Obsessive-Compulsive Disorder (OCD), pain,neurodegenerative disorders, paedopsychiatry and sleep. The evidence was more consistent in pain, OCD,mood disorders, and reaction to severe stress.EMDR’s efficiency across numerous pathological situations, highlighted the central role of affectivememory in several psychiatric and non-psychiatric conditions. Furthermore, EMDR seems to besuccessful in usually uncooperative (e.g. Dementia) or unproductive cases (e.g. aphasia). Moreover, insome severe medical situations were psychologic distress was an obstacle, EMDR allowed thecontinuation of treatment-as-usual. Our review suggests that it is a safe and economical therapeuticoption, and its effect in non-pathological situations opens new avenues for translational research. Overallmore methodologically rigorous studies are needed.

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