Radiocarbon in Marsh Periwinkle (Littorina Irrorata) Conchiolin: Applications for Archaeology

Radiocarbon ◽  
2019 ◽  
Vol 61 (5) ◽  
pp. 1489-1500
Author(s):  
Carla S Hadden ◽  
Kathy M Loftis ◽  
Alexander Cherkinsky ◽  
Brandon T Ritchison ◽  
Isabelle H Lulewicz ◽  
...  
Keyword(s):  
Dissolved Inorganic Carbon ◽  
The United States ◽  
Chemical Oxidation ◽  
Shell Weight ◽  
Apalachicola Bay ◽  
Shell Matrix ◽  
Novel Approach ◽  
Littorina Irrorata ◽  
Carbon Reservoir ◽  
Shell Carbonate

ABSTRACTIn coastal and island archaeology, carbonate mollusk shells are often among the most abundant materials available for radiocarbon (14C) dating. The marsh periwinkle (Littorina irrorata) is one of these such species, ubiquitously found along the Atlantic and Gulf coasts of the United States in both modern and archaeological contexts. This paper presents a novel approach to dating estuarine mollusks where rather than attempting to characterize the size and variability of reservoir effects to “correct” shell carbonate dates, we describe a compound-specific approach that isolates conchiolin, the organic matter bound with the shell matrix of the L. irrorata. Conchiolin typically constitutes <5% of shell weight. In L. irrorata, it is derived from the snail’s terrestrial diet and is thus not strongly influenced by marine, hardwater, or other carbon reservoir effects. We compare the carbon isotopes (δ13C and Δ14C) of L. irrorata shell carbonate, conchiolin, and bulk soft tissue from six modern, live-collected specimens from Apalachicola Bay, Florida, with samples that represent possible sources of carbon within their environment including surface sediments, marsh plant tissues, and dissolved inorganic carbon (DIC) in water. Ultimately, this paper demonstrates that samples obtained from wet chemical oxidation of L. irrorata conchiolin produces accurate 14C dates.

Carbon Reservoir Effects in Eastern Oyster from Apalachicola Bay, USA

Radiocarbon ◽  
2017 ◽  
Vol 59 (5) ◽  
pp. 1497-1506 ◽  
Author(s):  
Carla S Hadden ◽  
Alexander Cherkinsky
Keyword(s):  
Dissolved Inorganic Carbon ◽  
Eastern Oyster ◽  
Spatiotemporal Variability ◽  
Multiple Points ◽  
Study Region ◽  
Apalachicola Bay ◽  
Apalachicola River ◽  
Carbon Reservoir ◽  
River Dynamic ◽  
Eastern Edge

AbstractEastern oyster (Crassostrea virginica) is an ubiquitous estuarine shellfish taxon in eastern North America and one of the most abundant materials available for radiocarbon (14C) dating. We examine spatiotemporal variability in carbon reservoir effects among pre-bomb oysters from Apalachicola Bay, USA, a river-influenced estuary on the northern Gulf of Mexico. Shells were sampled at multiple points along the valve to produce time-series records of 14C variation during the lives of the mollusks. Conventional ages within shells differed by as little as 36 14C yr to as much as 295 14C yr. Reservoir offsets varied sub-regionally within the estuary, increasing from 92±37 yr in the eastern edge of study region to 227±110 yr in the west, reflecting the influence of 14C-depleted dissolved inorganic carbon from the Apalachicola River. Dynamic carbon reservoirs can pose problems for the estimation of ΔR and for building coastal chronologies. Estimating sub-regional ΔR values can be useful for assessing the range of variability in reservoir offsets within an estuary, and for correcting sample ages if the shell origin is known. Greater variability and/or uncertainty in ΔR lead to greater uncertainty in the calibrated age.

Forecasting Interconnections in International Housing Markets: Evidence from the Dynamic Model Averaging Approach

2020 ◽  
Vol 42 (1) ◽  
pp. 37-103
Author(s):  
Hardik A. Marfatia
Keyword(s):  
Dynamic Model ◽  
Model Averaging ◽  
Housing Markets ◽  
The United States ◽  
Forecasting Model ◽  
Change Over Time ◽  
The United Kingdom ◽  
Novel Approach ◽  
Dynamic Model Averaging ◽  
Over Time

In this paper, I undertake a novel approach to uncover the forecasting interconnections in the international housing markets. Using a dynamic model averaging framework that allows both the coefficients and the entire forecasting model to dynamically change over time, I uncover the intertwined forecasting relationships in 23 leading international housing markets. The evidence suggests significant forecasting interconnections in these markets. However, no country holds a constant forecasting advantage, including the United States and the United Kingdom, although the U.S. housing market's predictive power has increased over time. Evidence also suggests that allowing the forecasting model to change is more important than allowing the coefficients to change over time.

scholarly journals Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hannah B. Elam ◽  
Stephanie M. Perez ◽  
Jennifer J. Donegan ◽  
Daniel J. Lodge
Keyword(s):  
United States ◽  
Sensorimotor Gating ◽  
The United States ◽  
Dopamine Neuron ◽  
Neuron Activity ◽  
Sprague Dawley ◽  
Post Traumatic Stress ◽  
Neuron Population ◽  
Population Activity ◽  
Novel Approach

AbstractPost-traumatic stress disorder (PTSD) is a prevalent condition affecting approximately 8% of the United States population and 20% of United States combat veterans. In addition to core symptoms of the disorder, up to 64% of individuals diagnosed with PTSD experience comorbid psychosis. Previous research has demonstrated a positive correlation between symptoms of psychosis and increases in dopamine transmission. We have recently demonstrated projections from the paraventricular nucleus of the thalamus (PVT) to the nucleus accumbens (NAc) can regulate dopamine neuron activity in the ventral tegmental area (VTA). Specifically, inactivation of the PVT leads to a reversal of aberrant dopamine system function and psychosis-like behavior. The PVT receives dense innervation from orexin containing neurons, therefore, targeting orexin receptors may be a novel approach to restore dopamine neuron activity and alleviate PTSD-associated psychosis. In this study, we induced stress-related pathophysiology in male Sprague Dawley rats using an inescapable foot-shock procedure. We observed a significant increase in VTA dopamine neuron population activity, deficits in sensorimotor gating, and hyperresponsivity to psychomotor stimulants. Administration of selective orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R) antagonists (SB334867 and EMPA, respectively) or the FDA-approved, dual-orexin receptor antagonist, Suvorexant, were found to reverse stress-induced increases in dopamine neuron population activity. However, only Suvorexant and SB334867 were able to reverse deficits in behavioral corelates of psychosis. These results suggest that the orexin system may be a novel pharmacological target for the treatment of comorbid psychosis related to PTSD.

scholarly journals Pulmonary Embolism Response Teams: A Novel Approach for the Care of Complex Patients With Pulmonary Embolism

2018 ◽  
Vol 24 (9_suppl) ◽  
pp. 48S-55S ◽  
Author(s):  
Mateo Porres–Aguilar ◽  
Javier E. Anaya-Ayala ◽  
Gustavo A. Heresi ◽  
Belinda N. Rivera-Lebron
Keyword(s):  
Pulmonary Embolism ◽  
The United States ◽  
Cardiovascular Death ◽  
Pulmonary Embolectomy ◽  
Systemic Thrombolysis ◽  
Cardiopulmonary Support ◽  
Novel Approach ◽  
Adoption And Implementation ◽  
Complex Patients

Pulmonary embolism represents the third most common cause of cardiovascular death in the United States. Reperfusion therapeutic strategies such as systemic thrombolysis, catheter directed therapies, surgical pulmonary embolectomy, and cardiopulmonary support devices are currently available for patients with high- and intermediate-high–risk pulmonary embolism. However, deciding on optimal therapy may be challenging. Pulmonary embolism response teams have been designed to facilitate multidisciplinary decision-making with the goal to improve quality of care for complex cases with pulmonary embolism. Herein, we discuss the current role and strategies on how to leverage the strengths from pulmonary embolism response teams, its possible worldwide adoption, and implementation to improve survival and change the paradigm in the care of a potentially deadly disease.

Indo-Pacific Legal Infrastructure: A China Perspective

2019 ◽  
Vol 113 ◽  
pp. 374-378
Author(s):  
Matthew S. Erie
Keyword(s):  
International Economic ◽  
The United States ◽  
Pacific Region ◽  
Economic Law ◽  
Novel Approach ◽  
International Economic Law ◽  
Region I ◽  
Belt And Road ◽  
The Belt And Road ◽  
Legal Infrastructure

The Indo-Pacific, given its economic and geopolitical significance as exemplified by the growing multilateralism in the region, is an incubatory space for innovative legal infrastructure. Against the backdrop of growing tension between the United States and China in the region, I emphasize China's expanding footprint through the “Belt and Road Initiative” (BRI) and its capacity to shape institutions, practices, and norms of international economic law. I begin by providing context and then suggest six ways in which the BRI may offer a novel approach to international economic law, with particular salience for the Indo-Pacific region.

scholarly journals Market Diffusion of Extended Cycle Hormonal Contraceptives

2012 ◽  
Vol 3 (3) ◽  
Author(s):  
Megen Leeds Schumacher ◽  
Ashley Cetola Pettia ◽  
Albert I Wertheimer
Keyword(s):  
Hormonal Contraception ◽  
Target Population ◽  
Hormonal Contraceptive ◽  
The United States ◽  
Hormonal Contraceptives ◽  
Original Research ◽  
Main Concern ◽  
Novel Approach ◽  
Market Diffusion ◽  
Extended Cycle

Background: Extended cycle hormonal contraceptives (e.g. Seasonale, Seasonique) when introduced in 2003 were considered a very novel approach to contraception. The idea of manipulating the menstrual cycle so that women would experience just four menstruations a year was radical and was assumed to be responsible for the slow acceptance rate among the general public. Objective: This report analyzes two different aspects of the acceptance of this unique idea in the population. The first was the level of usage of extended cycle hormonal contraceptives in the general population, which was measured by a review of sales figures over time in the United States. The second was an examination of market diffusion as it relates to consumer perceptions regarding the characteristics of these products. Methods: To determine the degree of usage of extended cycle hormonal contraceptives the yearly sales, in terms of units sold, were compared with that of other leading methods of hormonal contraception. Along with the data, survey answers were obtained from 65 women who volunteered to participate in the study. Participants were selected randomly to represent the target population to assess the level of awareness about the benefits, risks, and any other concerns regarding the use of extended cycle hormonal contraceptives. Results: The yearly sales data of units sold showed a definitive increase in the sales of extended cycle hormonal contraceptives since their release on the market. The survey results showed an overwhelming awareness in the study population about the extended regimen. However, only about half of the women in the survey group were aware of its benefits. The main concern reported was the perceived significant side effect profile. Conclusion: Though awareness about the extended cycle hormonal contraception regimen was widespread, the survey population was not well informed about the advantages and the disadvantages regarding the degree of severity of side effects. To address these knowledge deficits, these aspects should be the focus when distributing information about extended cycle hormonal contraceptive regimens. This may boost the use of a potentially advantageous contraceptive regimen by a population who would derive benefit from its usage.   Type: Original Research

scholarly journals A Review of the First Long-term Implantable Continuous Glucose Monitoring System Available in the United States

2019 ◽  
Vol 15 (1) ◽  
pp. 160-166 ◽  
Author(s):  
Kevin Cowart
Keyword(s):  
Diabetes Mellitus ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
The United States ◽  
Relative Difference ◽  
Cochrane Library ◽  
Additional Clinical Trial ◽  
Novel Approach

Background: Although real-time continuous glucose monitoring (rtCGM) has been shown to improve glycemic control in patients with type 1 diabetes mellitus and type 2 diabetes mellitus treated with insulin, rates of adoption have been low. A novel approach, with the use of a long-term implantable continuous glucose monitoring (LTI CGM) has the potential to overcome barriers to rtCGM. The purpose of this review is to provide a background on the first LTI CGM technology to be approved, along with a review of contraindications, interference, safety, accuracy, and efficacy. Considerations for patient selection are discussed based on the available evidence. Methods: PubMed, EMBASE, and Cochrane Library were searched for keywords and subject headings to identify studies assessing LTI CGM. Results: Seven studies were identified which assessed LTI CGM. Mean absolute relative difference is similar to available CGM devices. Rates of adverse events were low. Change in hemoglobin A1c with LTI CGM may be comparable to rtCGM. Conclusions: Based on the available evidence, LTI CGM appears to be safe and accurate. Additional clinical trial investigation is warranted to evaluate the glycemic efficacy of LTI CGM.

Graft for Immediate use as First Stage of a Native Fistula

2009 ◽  
Vol 10 (3) ◽  
pp. 203-206 ◽  
Author(s):  
Earl Schuman
Keyword(s):  
United States ◽  
Graft Failure ◽  
The United States ◽  
Morbidity And Mortality ◽  
Dialysis Access ◽  
New Paradigm ◽  
Novel Approach ◽  
Native Fistula ◽  
Fistula Maturation

The majority of patients in the United States begin hemodialysis with a catheter. Many have immature or inadequate fistulae. At 90 days 77% of these patients are still using a catheter or a graft. The morbidity and mortality from prolonged catheter use have been well delineated. Although most of us adhere to the DOQI and Fistula First tenets, a fistula at all costs can seem counterproductive. A new paradigm is needed. The techniques described in this paper offer a novel approach to circumvent the problems of increasing catheter use and long fistula maturation times. The graft for immediate use is placed in the forearm and allows the proximal vessels to mature while providing dialysis access without a catheter. When these vessels meet maturation guidelines, or when surveillance indicates impending graft failure, a native fistula can be constructed and used in a 2–3 week period. This approach minimizes or circumvents catheter use altogether.

Development and characterization of microsatellite markers in Cynara cardunculus L.

Genome ◽  
2005 ◽  
Vol 48 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Alberto Acquadro ◽  
Ezio Portis ◽  
David Lee ◽  
Paolo Donini ◽  
Sergio Lanteri
Keyword(s):  
Molecular Markers ◽  
Fold Increase ◽  
The United States ◽  
Enriched Library ◽  
Globe Artichoke ◽  
Cynara Cardunculus ◽  
Principal Coordinates Analysis ◽  
Principal Coordinates ◽  
Novel Approach ◽  
Wild Cardoon

Cynara cardunculus L. is a species native to the Mediterranean basin that comprises 2 crops, globe artichoke (var. scolymus L.) and cultivated cardoon (var. altilis DC), as well as wild cardoon (var. sylvestris (Lamk) Fiori). Globe artichoke represents an important component of the South European agricultural economy but is also cultivated in North Africa, the Near East, South America, the United States, and China. Breeding activities and molecular marker studies have been, to date, extremely limited. Better knowledge of the genome of the species might be gained by developing a range of molecular markers. Here, we report on the development of 14 microsatellites (simple sequence repeats (SSRs)) through a novel approach that we have defined as the microsatellite amplified library (MAL). The approach represents a combination of amplified fragment length polymorphism and a primer extension based enriched library, is rapid, and requires no hybridization enrichment steps. The technique provided a ~40-fold increase in the efficiency of SSR identification compared with conventional library procedures. The developed SSRs were applied for genotyping 36 accessions of C. cardunculus, including a core of 27 varietal types of globe artichoke, 3 accessions of cultivated cardoon, and 6 Sicilian accessions of wild cardoon. Principal coordinates analysis made it possible to differentiate both cultivated and wild forms from each other.Key words: globe artichoke, wild and cultivated cardoon, molecular markers, AFLP, MAL (microsatellite amplified library).

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