scholarly journals Associations between C-reactive protein levels and cognition during the first 6 months after acute psychosis

2018 ◽  
Vol 31 (1) ◽  
pp. 36-45 ◽  
Author(s):  
Farivar Fathian ◽  
Else-Marie Løberg ◽  
Rolf Gjestad ◽  
Vidar M. Steen ◽  
Rune A. Kroken ◽  
...  
Keyword(s):  
Serum Level ◽  
Cognitive Performance ◽  
Acute Phase ◽  
Randomised Trial ◽  
Inverse Association ◽  
Acute Psychosis ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

AbstractObjectiveInverse relationships between the C-reactive protein (CRP) levels and cognitive performance in acute psychosis have been demonstrated. We aimed to investigate how the serum level and initial change of CRP in acutely admitted patients with psychosis was correlated with cognitive performance during a 6-months follow-up period.MethodsThe study is part of a pragmatic, randomised trial comparing four different second-generation antipsychotic drugs, and consists of 208 acute phase patients recruited at admittance for psychosis. This study reports data for all groups collectively, and does not compare treatment groups. Measurements of CRP and cognitive performance were conducted at baseline (T1) and after 4 weeks on average after inclusion (T2). Cognition was also assessed after 3 months (T3) and 6 months (T4) of follow-up.ResultsGlobal cognition improved during the follow-up period of 6 months, especially in the T1–T2 interval. The different cognitive subdomains showed different time-dependent profiles of improvement, with memory and attention improving significantly also in the later phases. Reduction of the CRP level during the initial follow-up interval (T1–T2) was associated with increased overall cognitive performance in the T2–T4 interval, but not in the T1–T2 interval. For the cognitive subdomains, we found an inverse association between change in CRP level and verbal abilities (T2–T4 interval), and attention (T2–T3 interval).ConclusionThese findings indicate that initial changes in the serum level of CRP in the acute phase of psychosis may predict cognitive function in later phases of the disease.

scholarly journals S87. THE INITIAL CHANGE IN THE SERUM LEVEL OF C-REACTIVE PROTEIN IN ACUTE PSYCHOSIS IS ASSOCIATED WITH COGNITIVE PERFORMANCE IN LATER PHASES

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S358-S359
Author(s):  
Farivar Fathian ◽  
Else-Marie Løberg ◽  
Rolf Gjestad ◽  
Vidar Martin Steen ◽  
Rune Kroken ◽  
...  
Keyword(s):  
Serum Level ◽  
Cognitive Performance ◽  
Acute Psychosis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Initial Change

scholarly journals The serum level of C-reactive protein (CRP) is associated with cognitive performance in acute phase psychosis

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Erik Johnsen ◽  
Farivar Fathian ◽  
Rune A. Kroken ◽  
Vidar M. Steen ◽  
Hugo A. Jørgensen ◽  
...  
Keyword(s):  
Serum Level ◽  
Cognitive Performance ◽  
Acute Phase ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract P096: Maternal Serum C-Reactive Protein Levels During Pregnancy and Risk for High C-Reactive Protein 7-13 Years Later

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Bonny Rockette-Wagner ◽  
Claudia Holzman ◽  
Bertha L Bullen ◽  
Andrew D Althouse ◽  
Janet M Catov
Keyword(s):  
Relative Risk ◽  
Weight Change ◽  
Elevated Serum ◽  
Maternal Serum ◽  
Health Study ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Inflammatory Status

Introduction: Elevated serum C-reactive protein (CRP) can be a marker of disease activity involving inflammation, such as pregnancy complications and cardiovascular disease (CVD). Systemically high levels of CRP in women, including during pregnancy, may indicate higher risk for CVD. It is unknown if CRP measured during the pro-inflammatory state of pregnancy correlates with concentrations assessed 7-13 years after delivery. Hypothesis: Concentrations of CRP assessed during pregnancy will be related to CRP measured several years after pregnancy, independent of weight gain. Methods: We studied the first 252 women enrolled in the follow-up of the Pregnancy Outcomes and Community Health Study (POUCHmoms 2011-2013) with complete CRP data for the pregnancy (mean gestational age: 22.36 [2.22] weeks) and POUCHmoms visits (mean follow-up: 10.76 [1.38] years). The relative risk for high hsCRP (≥ 3.39 μg/ml) at the follow-up visit, related to quartiles of CRP during pregnancy, was examined using stepwise regression models. Results: Median (IQR) levels of pregnancy CRP and hsCRP at the follow-up visit were 5.68 [3.08, 9.76] and 3.39 [0.69, 9.73] μg/ml, respectively. Although absolute values of hsCRP at follow-up were generally lower than pregnancy CRP, 56% of women in the top and bottom quartiles of pregnancy CRP (71 of 126) were in the same quartile for hsCRP at follow-up (figure). The relative risk of having high hsCRP (≥ 3.39 μg/ml) at follow-up ranged from 2.7-5.2 for the 2 nd - 4 th quartiles of pregnancy CRP (vs. the 1st quartile). Controlling for pre-pregnancy BMI and follow-up weight change, the relative risk of having high hsCRP at follow-up was significantly higher for the 2 nd (1.15 [1.02-1.30]),3 rd (1.19 [1.05-1.35), and 4 th (1.22 [1.05-1.41]) quartiles of pregnancy CRP. Conclusions: Pregnancy CRP levels are related to hsCRP levels several years later in this cohort of women, even after adjusting for pre-pregnancy BMI and follow-up weight change. CRP assessed in pregnancy may reflect inflammatory status later in life.

scholarly journals Acute Phase Response in Patients With Uncomplicated and Complicated Endoscopic Retrogradic Cholangiopancreaticography

HPB Surgery ◽  
1994 ◽  
Vol 8 (2) ◽  
pp. 129-131 ◽  
Author(s):  
Heikki Kiviniemi ◽  
Tatu Juvonen ◽  
Jyrki Mäkelä
Keyword(s):  
Prospective Study ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Response Curve ◽  
Serum Amylase ◽  
Phase Response ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Biliary Diseases

Acute phase response after endoscopic retrogradic cholangiopancreaticography (ERCP) was studied in 42 patients with suspected pancreatic or biliary diseases. In uncomplicated cases acute phase response determined by serum C-reactive protein levels was rare and did not parallel the serum amylase or lipase levels. In three of the these 42 patients, post-ERCP pancreatitis developed and CRP levels elevated sharply and paralleled the degree of pancreatitis. Six additional patients outside of this prospective study with post-ERCP-pancreatitis and daily CRP determinations were used to determine the CRP-response curve in post-ERCP pancreatitis.

scholarly journals Preoperative C-reactive protein levels to predict early and late mortalities after coronary artery bypass surgery: Eight years of follow-up

2009 ◽  
Vol 138 (4) ◽  
pp. 954-958 ◽  
Author(s):  
Albert H.M. van Straten ◽  
Mohamed A. Soliman Hamad ◽  
André J. van Zundert ◽  
Elisabeth J. Martens ◽  
Jacques P.A.M. Schönberger ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

Effect of compliance during periodontal maintenance therapy on c‐reactive protein levels: a 6‐year follow‐up

2020 ◽  
Author(s):  
Fernando Oliveira Costa ◽  
Rafael Paschoal Esteves Lima ◽  
Sheila Cavalca Cortelli ◽  
Adriana Moreira Costa ◽  
José Roberto Cortelli ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Periodontal Maintenance

Acute Phase Reactants Predict the Risk of Amputation in Diabetic Foot Infection

2011 ◽  
Vol 101 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Baris Akinci ◽  
Serkan Yener ◽  
Sena Yesil ◽  
Nur Yapar ◽  
Yasin Kucukyavas ◽  
...  
Keyword(s):  
Acute Phase ◽  
Diabetic Foot ◽  
Post Treatment ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Protein Levels ◽  
Reactive Protein ◽  
Diabetic Foot Infections ◽  
Cell Counts ◽  
White Blood Cell Counts

Background: Prediction of amputation would aid clinicians in the management of diabetic foot infections. We aimed to assess the predictive value of baseline and post-treatment levels of acute phase reactants in the outcome of patients with diabetic foot infections. Methods: We collected data prospectively during minimum follow-up of 6 months in patients with infected diabetic foot ulcers hospitalized in Dokuz Eylul University Hospital between January 1, 2003, and January 1, 2008. After excluding patients who did not attend the hospital for follow-up visits regularly (n = 36), we analyzed data from 165 foot ulcer episodes. Results: Limb ischemia and osteomyelitis were much more frequent in patients who underwent amputation. Wagner grade, which assesses ulcer depth and the presence of osteomyelitis or gangrene, was higher in patients who needed amputation. Ulcer size was slightly larger in the amputation group. Baseline and post-treatment C-reactive protein levels, erythrocyte sedimentation rates, white blood cell counts, and platelet counts were significantly elevated in patients who underwent amputation. Albumin levels were significantly suppressed in the amputation group. Univariate analysis showed that a 1-SD increase in baseline and post-treatment C-reactive protein levels, erythrocyte sedimentation rates, and white blood cell counts and a 1-SD decrease in post-treatment albumin levels were significantly associated with increased risk of amputation. Post-treatment C-reactive protein level was strongly associated with amputation risk. Conclusions: Circulating levels of acute phase reactants were associated with amputation risk in diabetic foot infections. (J Am Podiatr Med Assoc 101(1): 1–6, 2011)

Elevation of FVIII: C in Venous Thromboembolism Is Persistent and Independent of the Acute Phase Response

2000 ◽  
Vol 83 (01) ◽  
pp. 10-13 ◽  
Author(s):  
Andrew Mumford ◽  
Richard Manning ◽  
Michael Laffan ◽  
James O’Donnell
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Acute Phase Reaction ◽  
Phase Reaction ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Venous Thromboembolic

SummaryRecent literature has suggested a role for elevated FVIII:C in venous thromboembolic disease (VTED). However since FVIII:C is known to rise in response to an acute phase reaction, it is difficult to determine whether the increased FVIII:C precedes the thrombosis or represents a secondary reactive phenomenon. In an attempt to address this question, we followed 35 patients with confirmed VTED, raised FVIII:C level (>1.5 iu/ml) and no other thrombotic tendency. Serial measurements of FVIII:C, vWF:Ag, C-reactive protein and fibrinogen were performed. We hypothesized that a persistent increase in FVIII:C in the absence of any other measures of ongoing acute phase response, would support the idea that elevation of FVIII:C is a constitutional phenomenon.Of this initial group, 94% continued to have an elevated FVIII:C level throughout the period of follow up (median 8 months; range 3 to 39 months), with no significant difference between the FVIII:C levels determined at first estimation and those obtained during follow up (p = 0.58). Conversely, only 18% had evidence of an acute phase reaction when first assessed, and nonparametric ranking analysis demonstrated no correlation between FVIII:C and either C-reactive protein or fibrinogen (p = 0.315 and 0.425 respectively).We conclude that increased FVIII:C levels following VTED are persistent, independent of the acute phase reaction, and thus may represent a constitutional risk factor for VTED.

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