ω-3 and major depression: a review

2013 ◽  
Vol 26 (3) ◽  
pp. 178-185 ◽  
Author(s):  
Aline H. Mello ◽  
Aline Gassenferth ◽  
Luana R. Souza ◽  
Jucélia J. Fortunato ◽  
Gislaine T. Rezin
Keyword(s):  
Major Depression ◽  
Depressive Disorders ◽  
World Health ◽  
General View ◽  
Way Of Life ◽  
Beneficial Effects ◽  
The World ◽  
The Moment ◽  
Global Burden Of Diseases ◽  
Health Organization

BackgroundThe World Health Organization estimates that major depression affects about 350 million people all over the world and reports this disorder as the major contributor to the global burden of diseases. Despite the well-defined symptomatology, major depression is a heterogeneous psychiatric disorder whose pathophysiology is not clearly established. Although several treatments are available, most depressed patients do not achieve the complete remission of symptoms. Factors linked to the persistence of the disorder have been investigated, particularly those related to the way of life. Moreover, it has been suggested that nutritional aspects may influence its development. Among them, a diet rich in ω-3 has been associated with a reduced risk of major depression, although its deficiency is associated with depressive disorders.MethodsThis review provides a general view about evidences of the use of ω-3 in major depression cases.ResultsSeveral studies have demonstrated beneficial effects of ω-3 in the prevention and treatment of major depression. However, not all the results have shown significant statistical benefits.ConclusionsMore studies are necessary to clarify detailed mechanisms of the antidepressant effects of ω-3 and may explain the source of contradictions in results published until the moment.

scholarly journals Is hydroxychloroquine beneficial for COVID-19 patients?

2020 ◽  
Vol 11 (7) ◽  
Author(s):  
Xing Li ◽  
Ying Wang ◽  
Patrizia Agostinis ◽  
Arnold Rabson ◽  
Gerry Melino ◽  
...  
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Emergency Care ◽  
Public Health Emergency ◽  
World Health ◽  
Beneficial Effects ◽  
The World ◽  
Health Organization ◽  
Almost All ◽  
Effective Drugs

Abstract The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world1–3, the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 20204. The virus has reached almost all countries of the globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than 383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for effective drugs, in addition to the beneficial effects of remdesivir5, to control the disease and halt the pandemic.

scholarly journals Gestación y nacimiento de panendemia

2021 ◽  
Vol 53 (1) ◽  
Author(s):  
Alvaro Javier Idrovo
Keyword(s):  
Public Health ◽  
Public Health Emergency ◽  
World Health ◽  
Intermediate Step ◽  
International Response ◽  
The World ◽  
The Moment ◽  
Health Organization ◽  
Short Time ◽  
Very High

Words are born, compete with each other, and some die, showing the language dynamics and the influence of historical contexts1. During 2020, the meaning of the word pandemic has been discussed and a new meaning has emerged2,3. Traditionally in epidemiology, “pandemic” was used when in a relatively short time, there was a widespread geographical distribution of a disease, including some countries and continents4, which contrasts with the moment when the World Health Organization decided to decree it for the COVID-19 pandemic. In this case, the criteria indicated by the classic epidemiological definition were met several days before the pandemic was declared. Even an intermediate step was to declare Public Health Emergency of International Concern (PHEIC) understood as: “an extraordinary event which ‘constitute[s] a public health risk to other States through international spread of disease and…potentially require[s] a coordinated international response”5. In this way, potential panic was controlled, and the word pandemic was left for circumstances that require the maximum attention of all States, for a joint response, given its very high potential for disease and death.

scholarly journals Preparedness and Response Efforts to Fight against COVID-19 in Sub-Saharan Africa: Challenges and Opportunities

2020 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Sub Saharan Africa ◽  
World Health ◽  
African Countries ◽  
Global Pandemic ◽  
Laboratory Facility ◽  
The World ◽  
Challenges And Opportunities ◽  
Sub Saharan ◽  
The Moment ◽  
Health Organization

In late December the World Health Organization declared COVID-19 as global pandemic and needs international concern. As the novel corona virus rages through the world and spreads rapidly Africa is the least-affected continent at the moment. Sub-Saharan Africa is the home of more than one billion populations with fragile health system which is prone for the epidemic to occur. But Ebola experience left many African countries better prepared. We were searching all sources of the website related to preparation and prevention of COVID-19 in sub-Sahara Africa countries. Most African countries have established laboratory facility and implement the recommendations that terminate the outbreak COVID-19.

scholarly journals The R346K Mutation in the Mu Variant of SARS-CoV-2 Alter the Interactions with Monoclonal Antibodies from Class 2: A Free Energy of Perturbation Study

2021 ◽  
Author(s):  
Filip Fratev
Keyword(s):  
Free Energy ◽  
Monoclonal Antibodies ◽  
World Health ◽  
Receptor Binding Domain ◽  
Limited Data ◽  
Similar Reduction ◽  
The World ◽  
Class 1 ◽  
The Moment ◽  
Health Organization

The Mu variant of SARS-CoV-2 has been recently classified as a variant of interest (VOI) by the world health organization (WHO) but limited data are available at the moment. In particular, a special attention was given to the R346K mutation located in the receptor binding domain (RBD). In the current study we performed Free energy of perturbation (FEP) calculations to elucidate it possible impact on a set of neutralizing monoclonal antibodies (mAbs) which have been shown to be strong inhibitors of the most other known COVID-19 variants. Our results show that R346K affects the class 2 antibodies but its effect is not so significant (0.66 kcal/mol); i.e. reduces the binding with RBD about 3 times. An identical value was calculated also in the presence of both class 1 and class 2 antibodies (BD-812/836). Further, a similar reduction in the binding (0.4 kcal/mol) was obtained for BD-821/771 pair of mAbs. For comparison, the addition of K417N mutation, present in the newly registered Mu variant in July 2021 in UK, affected the class 1 mAbs by 1.29 kcal/mol reducing stronger the binding by about 10 times. Thus, the resistance effect of R346K mutation in the Mu variant is possible but not so significant and is due to the additional decrease of antibody neutralization based on the reduced binding of class 2 antibodies.

scholarly journals PANDEMIC AND CITY - A REASON FOR SEARCHING NEW APPROACHES IN DESIGN

2021 ◽  
Vol 81 (3) ◽  
pp. 46-54
Author(s):  
N. Tekenova ◽  
◽  
◽  
Keyword(s):  
Online Education ◽  
World Health Organization ◽  
Global Scale ◽  
Living Environment ◽  
World Health ◽  
Modern World ◽  
Remote Work ◽  
Way Of Life ◽  
The World ◽  
Health Organization

On March 11, 2020, the World Health Organization (WHO) announced the COVID-19 coronavirus pandemic in the world [1]. The modern world is faced with a pandemic on a global scale - the way of life of millions of people has changed. Quarantine mode, restrictions on movement, remote work, online education for schoolchildren and students, and much more. The author has developed a questionnaire on the Google platform of the questionnaire "City and Pandemic" [3] about the safety of the living environment. What should be a safe city? What needs to be changed in the design of cities in order to protect their residents from virus attacks? All these questions faced the society - architects, city planners, and urbanists began searching for ideas to solve new "quarantine" problems.

scholarly journals Medical and social rehabilitation for new coronavirus infection (covid-19). temporal methodological recommendations of the Russian Federation and European countries (literature review)

2021 ◽  
Vol 23 (4) ◽  
pp. 47-52
Author(s):  
Elena Y. Lapina ◽  
Anatoly A. Yakushev
Keyword(s):  
Causative Agent ◽  
International Committee ◽  
World Health ◽  
Republic Of China ◽  
The World ◽  
The Status ◽  
Coronavirus Infection ◽  
The Russian Federation ◽  
The Moment ◽  
Health Organization

At the end of 2019, the Peoples Republic of China (PRC) faced an outbreak of a new coronavirus infection, the causative agent of which was given the name 2019-nCoV. Subsequently, the World Health Organization (WHO) on February 11, 2020 gave the official name of the infection COVID-19 (Coronavirus disease 2019). The International Committee for Taxonomy of Viruses has named the causative agent SARS-CoV-2. The virus quickly spread throughout the world and acquired the status of an epidemic. It was necessary to develop algorithms for rapid diagnosis, provision of specialized medical care, as well as rehabilitation and prevention of recurrence. At the moment, all data is accumulated in real time. And the information on rehabilitation and prevention of re-infection is completely minimal.

scholarly journals Genealogies of Disability in Global Governance: A Foucauldian Critique of Disability and Development

2015 ◽  
pp. 67-83 ◽  
Author(s):  
Xuan-Thuy Nguyen
Keyword(s):  
Postcolonial Studies ◽  
World Health ◽  
Modern Development ◽  
The World ◽  
Development Goals ◽  
The Government ◽  
Historical Trajectory ◽  
Global Burden Of Diseases ◽  
Health Organization ◽  
Global And Local

In this article, I engage with the ways in which disability is governed within the Millennium Development Goals (MDGs) (United Nations 2000). Using a Foucauldian perspective on the governing of populations in modern states (Foucault 1991), I problematise this politics of disability and development by interrogating the ways in which biopower, through the constructions of modern development frameworks, has shaped our understanding of disability and impairment. I pursue this historical trajectory by tracing the emergence of the Global Burden of Diseases (GBD), a global study developed by the World Health Organization (WHO) and the World Bank in the 1990s (Murray and Lopez 1996). The forms of knowledge emerging in these global frameworks shed light on genealogies of disability in the twenty-first century. By re-visiting a postcolonial critique of Foucault’s conception of power in the context of Third World’s struggles for liberation (Said 1986), I suggest that a Foucauldian critique in disability and development could be deepened through its engagement with postcolonial studies. A critical and genealogical perspective on disability and development, I argue, is useful for understanding the government of disability and impairment in the intersections of global and local histories.

scholarly journals Preparedness, raising the level of preparedness and enhancing contemporary prevention methods to get rid of the risks of deadly health crises and their implications for the health of workers

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Hani Fadhil jumaah Al Shawi
Keyword(s):  
Health Promotion ◽  
World Health ◽  
Maximum Benefit ◽  
The World ◽  
Administrative Information ◽  
The Media ◽  
The Moment ◽  
Health Organization ◽  
Prevention Methods ◽  
High Degree

This study came to emphasize the importance of health promotion at the present time in all parts of the universe due to the federal movement witnessing the challenges of the Corona virus that originated from the Chinese city of Wuhan and spread in all countries of the world with amazing and terrifying speed (for bacterial, parasitic and viral causes) despite the WHO assurances Globalization with a high degree of responsibility, and this was evidenced by the calls and appeals of leaders of health organizations in the world for prevention, awareness, discussions and advice that they gave to all of humanity, as the virus has infected most of the world without exception between developed and developing countries alike. (In his speech, Tiedros Adhanom Gebresus is Secretary-General of the World Health Organization: February 27, 2020).As the virus evolved from the respiratory syndrome of the Middle East caused by cats to SARS, who moved between camels to Ebola and then developed to the most dangerous corona, which is transmitted between humans through touch, spray and breath, which has exceeded cases in the world to more than 600,000 patients with a confirmed infection And over 26 countries in the world until March 2020 and from here the researcher eagerly awaits the moment when investors announce their willingness to embrace any innovation related to the recovery from these epidemics. It is a logical result stemming from the feeling of great dismay that has caused mankind in recent times as a result of the outbreak of the Corona epidemic and the massive series of panic in all parts of the globe that left behind and the confusion that made the need to invent vaccines and ways to spread awareness in a timely and instant manner and seize the finest federal concept between the administration and the media related to the hadith The time is "Participate in the comprehensive awareness campaign and the highest levels of caution and caution" To achieve maximum benefit from it in combating, preventing, sterilizing, and identifying the most important pillars upon which it is based, and then showing the health benefits of workers in local organizations with a view to preserving them, and to achieve the desired benefit in sounding the work and promoting it with health by integrating administrative and health concepts with each other and circulating them through disseminating them Seminars and conferences in a manner that achieves the desired goal above:- So this effort was divided as follows. Part one: - will cover the systematic aspect of the studyThe second part: - He will be interested in presenting the concept, benefits and pillars of the essential participation. Part Three: - He will examine the concepts of health promotion activities for institutions.Part Four: - Examination and testing the feasibility of including the concept of substantive participation and activities of the health promotion unit...Part Five: - Results, Conclusions and Recommendations.The study recommended the necessity of disseminating the health information in addition to the administrative information in all institutions and segments of society in order to address firmly the prejudiced rumors and ideas aimed at impeding the administrative and health growth in our local institutions

Global evidence generation

2020 ◽  
pp. 453-464
Author(s):  
Adesola Ogunniyi
Keyword(s):  
Depressive Disorders ◽  
World Health ◽  
Middle Income ◽  
Middle Income Countries ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Special Mention ◽  
Global Burden Of Diseases ◽  
Health Organization ◽  
Evidence Generation

Disparities in the distribution of neurological and mental health disorders (NMHD) in different regions of the world can provide clues on the putative risk factors while providing basis for intervention strategies. This chapter utilizes the Global Burden of Diseases (GBD) data and the disability adjusted life years (DALY) calculations in the different World Health Organization (WHO) regions to adduce reasons for the peculiarities observed. The focus is on the most common NMHD, particularly those for which preventive strategies are likely to result in improved health outcomes for the majority of those affected. In this regard, stroke, epilepsy, and depressive disorders have been given special attention because of their high societal impact and the extensive studies from different regions. Dementia deserves special mention in view of its looming epidemic in low and middle income countries (LMICs), while its burden is lessening in high income countries (HICs) due to appropriate interventions and higher education.

scholarly journals Seasonality of Suicides among Victims Who Are under the Influence of Alcohol

2019 ◽  
Vol 16 (15) ◽  
pp. 2806 ◽  
Author(s):  
Dorota Lasota ◽  
Witold Pawłowski ◽  
Paweł Krajewski ◽  
Anna Staniszewska ◽  
Krzysztof Goniewicz ◽  
...  
Keyword(s):  
Causes Of Death ◽  
Depressive Disorders ◽  
Alcohol Concentration ◽  
World Health ◽  
Seasonal Patterns ◽  
The World ◽  
Common Risk Factors ◽  
Health Organization ◽  
Medical University ◽  
Death Date

Introduction: Suicide is one of the most frequent causes of death. According to the World Health Organization (WHO), each year, over eight hundred thousand people worldwide die as a result of suicide. The most common risk factors for suicide are depressive disorders and alcohol dependence. Alcohol can directly influence a decision about suicide, or be a factor facilitating this decision. The aim of the study was to analyse the seasonality of suicides among persons under the influence of alcohol. Material and Methods: Data for analysis were obtained from the Department of Forensic Medicine (DFM) of the Medical University of Warsaw. A retrospective analysis was performed on 317 victims of suicides by hanging, those which were entered into the registry of deaths kept by the DFM in the years 2009–2013. The analysis took into account the age and sex of victims, initial cause of death, date of post-mortem examination, autopsy result and alcohol concentration in the blood or muscles of the victims. Statistical analysis was performed using IBM SPSS Statistics version 20. Results: In the analysis, a spring peak of suicides was found for men, and an autumn peak was revealed for women. In addition, a significant correlation was observed between the age of victims and the concentration of alcohol; the older the victims, the higher the alcohol concentration. However, this correlation was reported only in the spring months. Conclusions: The results of the analysis seem to be consistent with seasonal patterns observed in other studies, and they indicate the occurrence of suicide seasonality. In order to improve the strategies of suicide prevention, it is necessary to identify factors which are related to the seasonal variation of suicidal behaviours, as well as to gain knowledge about the mechanisms behind this phenomenon.

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